Lab-on-phone citrate-capped silver nanosensor for lidocaine hydrochloride detection from a biological matrix

Ansari, Niha; Lodha, Anand; Pandya, Alok; Sutariya, Pinkesh G.; Menon, Shobhana K.

doi:10.1039/c5ay01977j

Cited by 24 publications

(12 citation statements)

References 43 publications

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“…Furthermore, due to the microdimensions, cells and particles tend to transit through these devices at a relatively high velocity. [8][9][10] Most of the smartphones are equipped with a high-end specification camera that supports the device as a platform for optic-based equipment such as spectrometry, [11] colorimetric, [12,13] fluorescence, and luminescence detection. However, these equipment is bulky and expensive which limits the practical application of microfluidics for real-time point-of-care detection, especially in the low resource settings.…”

Section: Doi: 101002/admt201800359mentioning

confidence: 99%

“…[6,7] As the smartphones are increasingly affordable with exponentially powerful processors, their usage for lab on a phone has emerged as an attractive option. [8][9][10] Most of the smartphones are equipped with a high-end specification camera that supports the device as a platform for optic-based equipment such as spectrometry, [11] colorimetric, [12,13] fluorescence, and luminescence detection. [14][15][16][17] The smartphone camera also allows for multiple optical zooms that favor the image capture and analysis for mobile microscopy application.…”

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confidence: 99%

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Portable Smartphone‐Based Platform for Real‐Time Particle Detection in Microfluidics

Salafi

Zeming

Lim

et al. 2018

Adv Materials Technologies

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Real‐time particle detection is an integral part of microfluidics for diagnostics. The detection method is typically performed with the use of bulky and expensive instruments including a bench‐top microscope, high‐speed camera, and fluidic pump. This limits the practical applications of microfluidics for real‐time point‐of‐care detection. Here, a portable and low‐cost smartphone microscopy platform is developed for real‐time particle detection in microfluidics based on a polydimethylsiloxane (PDMS) lens, modular 3D printed accessory, plug‐and‐play paper pump, and a novel particle counting algorithm. The PDMS lens is developed using a new method based on the PDMS precuring and hydrophobic modification on a pillar template to allow for fabrication of various lens shapes with high reproducibility and broad range magnification ratio from 30× to 100×. The modular 3D printed smartphone accessory allows for easy imaging setup to cater for different size of microchannel and the paper pump design provides a convenient single‐step process to drive the fluid. The platform is implemented to count the moving particles in the outlet of microfluidics deterministic lateral displacement with 94% counting accuracy. This platform provides huge potential applications for real‐time point‐of‐care detection that can be integrated with various microfluidic techniques.

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Section: Doi: 101002/admt201800359mentioning

confidence: 99%

mentioning

confidence: 99%

Portable Smartphone‐Based Platform for Real‐Time Particle Detection in Microfluidics

Salafi

Zeming

Lim

et al. 2018

Adv Materials Technologies

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“…Here, inspired by our previous studies (Lodha et al, 2014(Lodha et al, , 2013Ansari et al, 2015) and literature reports, we used green approach to synthesize AgNPs for determination of cystine and studied its correlation with time since death, as one of the realistic approaches in forensic science as well as in clinical diagnosis. At the same time we utilized the smartphone as a smart approach for determination of cystine, as smartphones equipped with a highresolution digital camera have become almost omnipresent in society which can be used to produce an image very conveniently.…”

Section: Introductionmentioning

confidence: 99%

Smart platform for the time since death determination from vitreous humor cystine

Ansari

Lodha

Menon

2016

Biosensors and Bioelectronics

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“…Menon's group reported the use of a smart phone as a portable and cost-effective colorimetric sensor for lidocaine hydrochloride determination in the range of 0.1-4.5 ng/ml in blood and vitreous humor samples. Using the citrated capped AgNPs probe as the aggregation of AgNPs occur rapidly in the presence of lidocaine due to the electrostatic and hydrogen-bonding interaction between them which results in color change from yellow to red [30].…”

Section: Silver Npsmentioning

confidence: 99%

Drug Detection in Biological Specimens: Recent Colorimetric Methods

Hamidi

2018

Bioanalysis

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Recently, the detection approaches based on the metal nanoparticles (NPs) have attracted more and more attention due to their great extinction coefficient and strong surface plasma resonance properties. This report focuses on the present status of drug detection with metal NPs as ultrasmall labels in colorimetric-based methods. Although progresses have been emerged in drug detection, much work remains to be done to overcome the great challenges on sample preparation of complicated biological fluids. Plasmonic NPs can be combined with other existing functional groups to produce frameworks with novel multifunctional surface plasmon resonance for generating optical platform in drug detection. With their continued progress, we believe that making high quality and multifunctional plasmonic materials will play an important role in the drug detection and quantification in biological samples. Many important disciplines involving human health are dealing with the analysis of drugs present in living organisms or biological fluids. Biological samples are difficult to handle owing to their inherent complexity and, sometimes, sample preparation processes such as tryptic digestion make them even more complex. However, in the case of simpler matrices such as exhaled breath condensate, the direct injection of sample to analytical instruments is possible [1][2][3]. This complexity hinders the reliable analysis in two ways. First, most biological fluids are not amendable with analytical instruments since all biological samples consist of a vast range of ions, proteins, lipids, carbohydrates and so on, and cannot be injected to analytical devices. Second, highly abundant interfering compounds disturb the identification and quantification of trace analytes at subnanogram per milliliter levels.A bioanalytical strategy consists of two integral stages:r Sample preparation (treatment/cleanup/extraction) of the target analyte from its complex biological matrix; r Separation, detection and quantification of the analyte.Common technologies for drug determination in body fluids including ELISA, chromatographic and electrophoretic-based methods suffer from several limitations in bioanalytical laboratories. Owing to the complex matrix of most biological specimens, they rely on time-and labor-consuming sample purification. Moreover, sophisticated instruments such as MS are not affordable by many of the laboratories and require effective extraction approaches [4][5][6][7][8]. It is noteworthy that the sensitivity of some of these technologies is not adequate for detecting the required levels of target analyte. Therefore, there is still a great demand to develop inexpensive, fast, user-friendly and easy-to-operate technologies.The association of nanotechnology with medical treatment, including therapeutic drug monitoring, pharmacokinetic and pharmacodynamic studies has provided a new concept in drug detection. Label-free detection systems with little to no sample preparation is more appreciated [9]. Colorimetric methods use the intrinsic advant...

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Lab-on-phone citrate-capped silver nanosensor for lidocaine hydrochloride detection from a biological matrix

Abstract: In the present investigation, we report the development of lab-on-phone, specific and sensitive citrate-capped silver nanosensor for lidocaine hydrochloride detection.

Cited by 24 publications

References 43 publications

Portable Smartphone‐Based Platform for Real‐Time Particle Detection in Microfluidics

Portable Smartphone‐Based Platform for Real‐Time Particle Detection in Microfluidics

Smart platform for the time since death determination from vitreous humor cystine

Drug Detection in Biological Specimens: Recent Colorimetric Methods

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