Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach

Xu, Dan‐Xia; Vachon, Martin; Densmore, A.; Ma, R.; Delâge, A.; Janz, Siegfried; Lapointe, J.; Li, Y.; Lopinski, Gregory P.; Zhang, D.; Liu, Q. Y.; Cheben, Pavel; Schmid, Jens H.

doi:10.1364/ol.35.002771

Cited by 97 publications

(76 citation statements)

References 11 publications

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“…For a given envelope period, Eq. (1) and (5) show that the sensitivity is in good approximation proportional to the optical roundtrip length of the resonators in the cascaded. Note that for an increasing refractive index n env the resonance wavelength of a single ring resonator will always shift to larger wavelengths, while the central wavelength of the envelope peak in the transmission spectrum of the cascade will shift to smaller wavelengths if f sr f ilter < f sr sensor and to larger wavelengths if f sr f ilter > f sr sensor .…”

Section: Inmentioning

confidence: 92%

Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation

2011

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Recently, cheap silicon-on-insulator label-free ring resonator biosensors have been demonstrated that allow fast and accurate quantitative detection of biologically relevant molecules for applications in medical diagnostics and drug development. However, a further improvement of their detection limit is limited by their small sensitivity and an expensive tunable laser is typically required to resolve the sharp resonances for wavelength interrogation. Therefore, we experimentally investigated the use of a Vernier-cascade sensor that achieves a sensitivity (thousands of nm/RIU) that is an order of magnitude larger than that of a ring resonator sensor (approx. 100 nm/RIU), while still maintaining sharp spectral features that allow precise monitoring of spectral shifts with data-fitting. Moreover we prove that it's also possible to accurately interrogate the sensor with a low-cost broadband light source by integrating it with an arrayed waveguide grating spectral filter that divides the sensor's transmission spectrum in multiple wavelength channels and transmits them to spatially separated output ports. Experiments show that this sensor can monitor refractive index changes of watery solutions in real-time with a detection limit (1.6 · 10 −5 RIU ) competitive with more expensive interrogation schemes, indicating its applicability in low-cost label-free biosensing.

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Section: Inmentioning

confidence: 92%

Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation

2011

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“…Label-free detection is a solution to this involving a transducer that directly measures some physical property of the biological compound. This transducer can be mechanical [2,3], electrical [4,5], or optical [6,7].…”

Section: Introduction: the Manuscriptmentioning

confidence: 99%

“…Optical label-free biosensors have received considerable attention over the past years [6][7][8][9]. The key behind optical biosensors' ability to detect biological analytes is that they are able to translate a change in the propagation speed of light into a quantifiable signal proportional to the amount of biological material present on the sensor surface.…”

Section: Introduction: the Manuscriptmentioning

confidence: 99%

Reaction tubes: A new platform for silicon nanophotonic ring resonator sensors

Arce

Put²,

Goes

et al. 2014

Journal of Applied Physics

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Label-free biosensing with silicon nanophotonic ring resonator sensors has proven to be an excellent sensing technique for achieving high throughput and high sensitivity, comparing favorably with other labeled and label-free sensing techniques.However, as in any biosensing platform, silicon nanophotonic ring resonator sensors require a fluidic component which allows the continuous delivery of the sample to the sensor surface. This is the big disadvantage of this platform since this type of microfluidic system is very much removed from the daily practice in e.g. hospital labs, which still relies to a large degree on platforms like 96-well microtiter plates, or reaction tubes. To address this major drawback, we propose the combination of a simple and lab-compatible reaction tube platform, with label-free nanophotonic biosensors with a special microfluidic system imbedded into the same chip, where the flow is through the chip rather than over the chip as in more traditional approaches. This shows that label-free nanophotonic ring resonators can be also used in the user-friendly platform like reaction tubes or well microtiter plates, conserving their excellent performance.

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“…The compatibility with mature CMOS technology provides the basis for mass fabrication at low cost and the possibility to fabricate large sensor arrays on a common substrate with ultra-compact sized resonators (≤5 μm) that additionaly offer high sensitivities and low detection limits. 1,2 Instead of using crystalline silicon-on-insulator (SOI) wafers as photonic substrates, low-loss hydrogenated amorphous silicon (a-Si:H) that is deposited by plasma-enhanced chemical vapor deposition (PECVD) is alternatively employed in this work because it provides a high refractive index (n ≈ 3.5) and low-loss material for near-infrared photonics, both comparable to crystalline silicon. 3 However, a-Si:H offers a more flexible fabrication process since it can be deposited at relatively low temperatures (≤300°C) and therefore allows using glass or plastic materials as substrates.…”

Section: Introductionmentioning

confidence: 99%

Label-free photonic biosensors fabricated with low-loss hydrogenated amorphous silicon resonators

Lipka

2013

J. Nanophoton

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Abstract. The precise detection of chemicals and biomolecules is of great interest in the areas of biotechnology and medical diagnostics. Thus, there is a need for highly sensitive, small area, and low-cost sensors. We fabricated and optically characterized hydrogenated amorphous silicon photonic resonators for label-free lab-on-chip biosensors. The sensing was performed with small-footprint microdisk and microring resonators that detect a refractive-index change via the evanescent electric field. Homogeneous sensing with NaCl and surface-sensing experiments with immobilized bovine serum albumin (BSA) were carried out. A sensitivity as high as 460 nm∕RIU was measured for NaCl dissolved in deionized water for the disk, whereas about 50 nm∕RIU was determined for the ring resonator. The intrinsic limits of detection were calculated to be 3.3 × 10 −4 and 3.2 × 10 −3 at 1550-nm wavelength. We measured the binding of BSA to functionalized ring resonators and found that molecular masses can be detected down to the clinically relevant femtogram regime. The detection and quantification of related analytes with hydrogenated amorphous silicon photonic sensors can be used in medical healthcare diagnostics like point-of-care-testing and biotechnological screening. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach

Cited by 97 publications

References 11 publications

Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation

Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation

Reaction tubes: A new platform for silicon nanophotonic ring resonator sensors

Label-free photonic biosensors fabricated with low-loss hydrogenated amorphous silicon resonators

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