Label-Free Detection of DNA Hybridization Utilizing Dual S-Tapered Thin-Core Fiber Interferometer

Zhang, Xu; Liu, Bo; Zeng, Hao; Song, Binbin; Wu, Jixuan; Duan, Shaoxiang

doi:10.1109/jlt.2018.2864798

Cited by 21 publications

(8 citation statements)

References 23 publications

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“…The reported sensor showed a very high degree of selectivity. Similarly, Zhang et al proposed a biochemical sensor using TCF sandwiched by dual s-tapered fiber for label-free selective detection of DNA hybridization . The sensing probe is constructed by splicing a TCF segment with a length of 645 μm in between two normal SMFs.…”

Section: Work Reported On Various Mzi Platformsmentioning

confidence: 99%

Label-Free Biochemical Sensing Using Processed Optical Fiber Interferometry: A Review

Jha,

Gorai,

Shrivastav

et al. 2024

ACS Omega

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Over the last 20 years, optical fiber-based devices have been exploited extensively in the field of biochemical sensing, with applications in many specific areas such as the food processing industry, environmental monitoring, health diagnosis, bioengineering, disease diagnosis, and the drug industry due to their compact, label-free, and highly sensitive detection. The selective and accurate detection of biochemicals is an essential part of biosensing devices, which is to be done through effective functionalization of highly specific recognition agents, such as enzymes, DNA, receptors, etc., over the transducing surface. Among many optical fiber-based sensing technologies, optical fiber interferometry-based biosensors are one of the broadly used methods with the advantages of biocompatibility, compact size, high sensitivity, high-resolution sensing, lower detection limits, operating wavelength tunability, etc. This Review provides a comprehensive review of the fundamentals as well as the current advances in developing optical fiber interferometry-based biochemical sensors. In the beginning, a generic biosensor and its several components are introduced, followed by the fundamentals and state-of-art technology behind developing a variety of interferometry-based fiber optic sensors. These include the Mach−Zehnder interferometer, the Michelson interferometer, the Fabry−Perot interferometer, the Sagnac interferometer, and biolayer interferometry (BLI). Further, several technical reports are comprehensively reviewed and compared in a tabulated form for better comparison along with their advantages and disadvantages. Further, the limitations and possible solutions for these sensors are discussed to transform these in-lab devices into commercial industry applications. At the end, in conclusion, comments on the prospects of field development toward the commercialization of sensor technology are also provided. The Review targets a broad range of audiences including beginners and also motivates the experts helping to solve the real issues for developing an industry-oriented sensing device.

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Section: Work Reported On Various Mzi Platformsmentioning

confidence: 99%

Label-Free Biochemical Sensing Using Processed Optical Fiber Interferometry: A Review

Jha,

Gorai,

Shrivastav

et al. 2024

ACS Omega

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“…Fig. 9 A schematic diagram of different single tapered (a) SMF [181], (b) SMS [194], (c) SSCS [201], (d) SNCS [205], (e) SHCS [212] fiber structure, (f) SEM image of Nile red coated tapered SCF [204], (g) single molecule detection of biomarker and localized cellular photothermal therapy [193], (h) tapered SNCS for ultrahigh sensitivity detection of hCG with signal amplification of magnetic microspheres [210]. Reprinted with permission from [204], [193] and [210].…”

Section: A a Tapered Sms Fiber Structurementioning

confidence: 99%

“…9(c)), which has ultrahigh RI sensitivity of 19212.5 nm/RIU [202]. The tapered SSCS fiber was then functionalized with sol gel for ammonia sensing [203], simultaneous measurement of methanol and ethanol concentration [204] and DNA detection with an S-tapered configuration [205].…”

Section: A a Tapered Sms Fiber Structurementioning

confidence: 99%

Singlemode-Multimode-Singlemode Fiber Structures for Sensing Applications—A Review

Liu

et al. 2021

IEEE Sensors J.

127

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A singlemode-multimode-singlemode (SMS) fiber structure consists of a short section of multimode fiber fusionspliced between two SMS fibers. The mechanism underpinning the operation of an SMS fiber structure is multimode interference and associated self-imaging. SMS structures can be used in a variety of optical fiber systems but are most commonly used as sensors for a variety of parameters, ranging from macro-world measurands such as temperature, strain, vibration, flow rate, RI and humidity to the micro-world with measurands such as proteins, pathogens, DNA, and specific molecules. While traditional SMS structures employ a short section of standard multimode fiber, a large number of structures have been investigated and demonstrated over the last decade involving the replacement of the multimode fiber section with alternatives such as a hollow core fiber or a tapered fiber. The objective of replacing the multimode fiber has most often been to allow sensing of different measurands or to improve sensitivity. In this paper, several different categories of SMS fiber structures, including traditional SMS, modified SMS and tapered SMS fiber structures are discussed with some theoretical underpinning and reviews of a wide variety of sensing examples and recent advances. The paper then summarizes and compares the performances of a variety of sensors which have been published under a number of headings. The paper concludes by considering the challenges faced by SMS based sensing schemes in terms of their deployment in real world applications and discusses possible future developments of SMS fiber sensors.

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“…OFOF bio-chemical sensors based on MZI have been investigated for several decades, and various types of structures have been reported, including microcavities, [215,216] microfibers, [217][218][219][220][221] and other types of fibers. Other types of fibers include thin-core fiber, [222] TCF, [223] HTCF, [45,46] dual sidehole fiber (DSHF). [49] These MZIs have been used to measure RI, gas pressure, DNA, protein concentration, glucose concentration, and vitamin C concentration, etc.…”

Section: Structures and Sensing Applicationsmentioning

confidence: 99%

Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

Zhang

Zhou

et al. 2021

Laser & Photonics Reviews

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Optofluidic, as an emerging technology that combines photons and microfluidics, has become a powerful, intelligent, and universal sensing platform in the field of bio-chemical sensing. Optical fiber optofluidic (OFOF), as a branch of optofluidic technology, has stimulated a host of remarkable achievements in the field of bio-chemical sensing due to its superiority of compact structure, immunity to electromagnetic interference, low sample consumption, high sensitivity, and real-time dynamic response. In this paper, an overview of OFOF bio-chemical sensors is presented. The OFOF system architectures are introduced and some advanced functional materials and coating technologies that can be utilized in the OFOF sensing platform to achieve high-performance biochemical sensing are summarized. Research progress and current status of OFOF bio-chemical sensors based on various sensing mechanisms are summarized and analyzed, with emphases on their sensing principles, sensing structures, sensing applications, advantages, and disadvantages. Lastly, the existing challenges and future development trends of OFOF biochemical sensors are briefly discussed.

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Label-Free Detection of DNA Hybridization Utilizing Dual S-Tapered Thin-Core Fiber Interferometer

Cited by 21 publications

References 23 publications

Label-Free Biochemical Sensing Using Processed Optical Fiber Interferometry: A Review

Label-Free Biochemical Sensing Using Processed Optical Fiber Interferometry: A Review

Singlemode-Multimode-Singlemode Fiber Structures for Sensing Applications—A Review

Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

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