Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen

Wang, Yaoguang; Wang, Yulan; Wu, Dan; Ma, Hongmin; Zhang, Yihe; Fan, Dawei; Pang, Xuehui; Du, Bin; Wei, Qin

doi:10.1016/j.snb.2017.07.129

Cited by 144 publications

(46 citation statements)

References 53 publications

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“…Fe 3 O 4 /GO nanocomposites were synthesized based on the previous reported method with a little modification [43,44]. Briefly, 15 mg GO was ultrasonic dispersed in 75 mL (CH 2 OH 2 ) 2 for 2.5 h. Afterwards, 0.81 g FeCl 3 was added to the above GO aqueous solution and dissolved thoroughly.…”

Section: Preparation Of Fe 3 O 4 /Go Nanocompositesmentioning

confidence: 99%

A Label-Free Immunosensor Based on Graphene Oxide/Fe3O4/Prussian Blue Nanocomposites for the Electrochemical Determination of HBsAg

et al. 2020

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In this article, a highly sensitive label-free immunosensor based on a graphene oxide (GO)/Fe3O4/Prussian blue (PB) nanocomposite modified electrode was developed for the determination of human hepatitis B surface antigen (HBsAg). In this electrochemical immunoassay system, PB was used as a redox probe, while GO/Fe3O4/PB nanocomposites and AuNPs were prepared and coated on screen-printed electrodes to enhance the detection sensitivity and to immobilize the hepatitis B surface antibody (HBsAb). The immunosensor was fabricated based on the principle that the decrease in peak currents of PB is proportional to the concentration of HBsAg captured on the modified immunosensor. The experimental results revealed that the immunosensor exhibited a sensitive response to HBsAg in the range of 0.5 pg·mL−1 to 200 ng·mL−1, and with a low detection limit of 0.166 pg·mL−1 (S/N = 3). Furthermore, the proposed immunosensor was used to detect several clinical serum samples with acceptable results, and it also showed good reproducibility, selectivity and stability, which may have a promising potential application in clinical immunoassays.

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Section: Preparation Of Fe 3 O 4 /Go Nanocompositesmentioning

confidence: 99%

A Label-Free Immunosensor Based on Graphene Oxide/Fe3O4/Prussian Blue Nanocomposites for the Electrochemical Determination of HBsAg

et al. 2020

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“…To date, different strategies have been used to measure CEA, such as radioimmunoassay [12], chemiluminescence analysis [13], enzyme-linked immunosorbent assay [14,15], and electrochemistry [16,17]. Among these methods, electrochemical immunosensors [18,19] have attracted considerable attention due to their distinct advantages, such as high selectivity, fast response, low sample requirements, miniaturization, and excellent sensitivity [20][21][22][23]. Nonetheless, new immunosensors fabricated with nanomaterials that have excellent performance for the quick and simple detection of CEA with high sensitivity and selectivity are still urgently needed in the medical field.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Immunosensor for Sensitive Detection of the Tumor Marker Carcinoembryonic Antigen (CEA) Based on Three-Dimensional Porous Nanoplatinum/Graphene

Jing

Wei

et al. 2020

Micromachines

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Carcinoembryonic antigen (CEA) is an important broad-spectrum tumor marker. The quantitative detection of a low concentration of CEA has important medical significance. In this study, three-dimensional porous graphene-oxide-supported platinum metal nanoparticles (3DPt/HGO) composites were prepared by a wet chemical method and modified on an electrode with enhanced conductivity, a large surface area, and good adsorption of immobilizing antibodies (Ab1). Horseradish peroxidase (HRP)-functionalized Au nanoparticles were fabricated to label the secondary antibodies (Ab2). The proposed immunosensor showed a good linear relationship in the range of 0.001–150 ng/mL for CEA and a detection limit of 0.0006 ng/mL. The immunosensor had high sensitivity, good stability and reproducibility, and has great application prospects for the clinical diagnosis of cancer.

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“…Several MoS 2 morphologies have been exploited in an attempt to maximize HER activity including vertically aligned flakes with modified termination, 3D MoS 2 /graphene foams, core‐shell structures with metals, metal oxides, or other TMDs, and defect‐rich basal planes laden with lattice substitutions or decorated with nanoparticles . Specifically, interest has been given towards the formation of composite electrodes, in some cases, composed of MoS 2 and minimal amounts of silver (Ag) and/or palladium (Pd) .…”

Section: Introductionmentioning

confidence: 99%

Catalytic Hydrogen Evolution Reaction Enhancement on Vertically Aligned MoS₂ by Synergistic Addition of Silver and Palladium

et al. 2020

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Hybrid electrodes containing MoS2 with metals active for the hydrogen evolution reaction (HER) are highly desirable as they can provide a cost‐effective and active route for producing hydrogen. It is well known that the technique used to facilitate such hybrid formation plays a critical role in the activity and stability of the electrode. Here we utilized a novel method for hybridization based on electron‐beam deposition of Ag, Pd, and Mo to make precursor films which, upon sulfurization, formed hybrid electrodes based on vertically aligned molybdenum disulfide (VA‐MoS2). We further modified the surface of these electrodes by exploiting galvanic replacement of palladium. Surprisingly, both hybridization techniques showed a synergistic effect between Pd and Ag, and enhanced activity was enabled by the presence of both metals. XPS, XRD, Raman spectroscopy, and FIB‐EM were used to explore the root cause of the synergy. It appears that enhanced performance is based partially on the mutual solubility of Pd−Ag and the facile diffusion of Ag through the MoS2 film. Ag/VA‐MoS2 modified by galvanic replacement provided 10 mA/cm2 at 210 mV of overpotential and was stable for up to 4000 cycles, surpassing the stability of previously reported Pd/MoS2 hybrids, making these techniques of interest for future generations of hybrid HER electrodes based on MoS2.

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Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen

Cited by 144 publications

References 53 publications

A Label-Free Immunosensor Based on Graphene Oxide/Fe3O4/Prussian Blue Nanocomposites for the Electrochemical Determination of HBsAg

A Label-Free Immunosensor Based on Graphene Oxide/Fe3O4/Prussian Blue Nanocomposites for the Electrochemical Determination of HBsAg

An Electrochemical Immunosensor for Sensitive Detection of the Tumor Marker Carcinoembryonic Antigen (CEA) Based on Three-Dimensional Porous Nanoplatinum/Graphene

Catalytic Hydrogen Evolution Reaction Enhancement on Vertically Aligned MoS₂ by Synergistic Addition of Silver and Palladium

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Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen

Cited by 144 publications

References 53 publications

A Label-Free Immunosensor Based on Graphene Oxide/Fe3O4/Prussian Blue Nanocomposites for the Electrochemical Determination of HBsAg

A Label-Free Immunosensor Based on Graphene Oxide/Fe3O4/Prussian Blue Nanocomposites for the Electrochemical Determination of HBsAg

An Electrochemical Immunosensor for Sensitive Detection of the Tumor Marker Carcinoembryonic Antigen (CEA) Based on Three-Dimensional Porous Nanoplatinum/Graphene

Catalytic Hydrogen Evolution Reaction Enhancement on Vertically Aligned MoS2 by Synergistic Addition of Silver and Palladium

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Catalytic Hydrogen Evolution Reaction Enhancement on Vertically Aligned MoS₂ by Synergistic Addition of Silver and Palladium