Label-free optical sensor based on liquid crystal sessile droplet array for penicillin G determination

Xie, Shuting; He, Ri; Zhu, Qifan; Jin, Mingliang; Yang, Ruizhi; Shen, Shitao; Cui, Jiayi; Zou, Yiying; Shui, Lingling

doi:10.1016/j.colsurfa.2022.128728

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…When observed under polarized optical microscope (Fig. 5f), the 5CB droplets show clear typical four-leaf-clover patterns according to the vertical anchoring by surfactant of SDS in the con ned spherical droplets (Xie et al 2022). The above results illustrate that the FCOMD could be widely applied for different uidic materials, including oil, water, liquid crystal, colloidal dispersion, etc, expanding the related application in material science, foods, pharmaceuticals and cosmetics.…”

Section: Fcomd For Creation Of Droplets For Assemblymentioning

confidence: 75%

A Floating Capillary Based Open Microfluidic Device for Stable and On- Demand Generation of Monodispersed Emulsion Droplets

Deng,

Xie,

Yang

et al. 2024

Preprint

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Simple and stable generation of monodispersed droplets with volume from picolitre to nanoliter is one of the key factors in high-throughput quantitative microreactors for chemical and biomedical applications. In this work, a floating capillary based open microfluidic device (FCOMD) is constructed by inserting a capillary with an oblique angle (α) into the continuous phase (CP) to develop a simple method for preparation of monodispersed droplet. The geometrical parameters, including inner diameter and α, present a strong correlation for the controllability of droplet breakage and thus its volume. According to the microfluidic experiments, the mechanism of breakup of dispersed phase (DP) into droplets in the FCOMD was proposed from the aspect of energy. The transition of droplet generating mode between dripping and jetting can be achieved by changing the DP capillary number and α. Water in oil (W/O), oil in water (O/W), double-emulsion, colloidal dispersed droplets and liquid crystal droplets with diameter ranges from 25–800 µm (CVs under 2%) are prepared on-demand by the FCOMD. To improve the generating throughput, different numbers of capillaries are integrated for an integrated FCOMD. This FCOMD shows the features of simple, stable, practicable, and flexible, showing a great potential application in material science, foods, pharmaceuticals and cosmetics.

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Section: Fcomd For Creation Of Droplets For Assemblymentioning

confidence: 75%

A Floating Capillary Based Open Microfluidic Device for Stable and On- Demand Generation of Monodispersed Emulsion Droplets

Deng,

Xie,

Yang

et al. 2024

Preprint

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“…Recently, a sessile LC droplet array prepared via inkjet printing was developed by Xie and co-authors to detect penicillin G. It was achieved through the penicillinase-catalyzed enzymatic hydrolysis of penicillin G; the release of H + , in turn, protonated PBA and led to the formation of a PBA monolayer. The molecular orientation change was visualized through axial-to-windmill texture transition under POM within several minutes, with an LOD of 0.178 ng/mL [ 163 ]. The stable polymer film for LC droplet anchoring makes it possible to fabricate a wearable sensing device, which can be applied in more fields.…”

Section: Applications In Lc Biochemical Sensorsmentioning

confidence: 99%

State-of-the-Art Development in Liquid Crystal Biochemical Sensors

et al. 2022

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As an emerging stimuli-responsive material, liquid crystal (LC) has attracted great attentions beyond display applications, especially in the area of biochemical sensors. Its high sensitivity and fast response to various biological or chemical analytes make it possible to fabricate a simple, real-time, label-free, and cost-effective LC-based detection platform. Advancements have been achieved in the development of LC-based sensors, both in fundamental research and practical applications. This paper briefly reviews the state-of-the-art research on LC sensors in the biochemical field, from basic properties of LC material to the detection mechanisms of LC sensors that are categorized into LC-solid, LC–aqueous, and LC droplet platforms. In addition, various analytes detected by LCs are presented as a proof of the application value, including metal ions, nucleic acids, proteins, glucose, and some toxic chemical substances. Furthermore, a machine-learning-assisted LC sensing platform is realized to provide a foundation for device intelligence and automatization. It is believed that a portable, convenient, and user-friendly LC-based biochemical sensing device will be achieved in the future.

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“…7,8 Therefore, they have been widely applied in information displays, 9,10 laser resonators, 11 and chemical and biomolecular sensors. 12,13…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Therefore, they have been widely applied in information displays, 9,10 laser resonators, 11 and chemical and biomolecular sensors. 12,13 Ch-LCs can be prepared via a host-guest approach by introducing chiral guest molecules into an achiral liquid crystalline host. 14,15 This approach makes the orientation of the self-assembly units (director, n) twist in the direction perpendicular to the molecular axis through noncovalent interactions, such as H-bonding.…”

Section: Introductionmentioning

confidence: 99%

Strain-induced recognition of molecular and chirality in cholesteric liquid crystal droplets for distance and curvature sensing

et al. 2023

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Label-free optical sensor based on liquid crystal sessile droplet array for penicillin G determination

Cited by 8 publications

References 39 publications

A Floating Capillary Based Open Microfluidic Device for Stable and On- Demand Generation of Monodispersed Emulsion Droplets

A Floating Capillary Based Open Microfluidic Device for Stable and On- Demand Generation of Monodispersed Emulsion Droplets

State-of-the-Art Development in Liquid Crystal Biochemical Sensors

Strain-induced recognition of molecular and chirality in cholesteric liquid crystal droplets for distance and curvature sensing

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