Label-free sensitive detection of MUC1 using a liquid crystal based-system

Duong, Duong Song Thai; Jang, Chang‐Hyun

doi:10.1080/02678292.2020.1729426

Cited by 9 publications

(2 citation statements)

References 31 publications

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“…Duong et al reported the use of a liquid-crystal-based aptasensor which employed the orientation properties of nematic liquid crystals (LCs) for MUC1 detection. 143 The biosensor was constructed by immobilizing amine-modified aptamers on the LC surface for target recognition. When MUC1 bound to the aptamers, it formed a MUC1−aptamer complex which distorted the LCs' orientation, changing from homeotropic to a random orientation.…”

Section: Aptasensors For Detection Applicationsmentioning

confidence: 99%

“…Therefore, this dual-mode aptasensor was able to detect MUC1 both quantitatively and qualitatively. Duong et al reported the use of a liquid-crystal-based aptasensor which employed the orientation properties of nematic liquid crystals (LCs) for MUC1 detection . The biosensor was constructed by immobilizing amine-modified aptamers on the LC surface for target recognition.…”

Section: Aptasensors For Detection Applicationsmentioning

confidence: 99%

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Recent Developments in Aptasensors for Diagnostic Applications

Liu

Wang

et al. 2020

ACS Appl. Mater. Interfaces

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Aptamers are exciting smart molecular probes for specific recognition of disease biomarkers. A number of strategies have been developed to convert target−aptamer binding into physically detectable signals. Since the aptamer sequence was first discovered, a large variety of aptamer-based biosensors have been developed, with considerable attention paid to their potential applications in clinical diagnostics. So far, a variety of techniques in combination with a wide range of functional nanomaterials have been used for the design of aptasensors to further improve the sensitivity and detection limit of target determination. In this paper, the advantages of aptamers over traditional antibodies as the molecular recognition components in biosensors for high-throughput screening target molecules are highlighted. Aptamer−target pairing configurations are predominantly single-or dual-site binding; the design of recognition modes of each aptamer−target pairing configuration is described. Furthermore, signal transduction strategies including optical, electrical, mechanical, and masssensitive modes are clearly explained together with examples. Finally, we summarize the recent progress in the development of aptamer-based biosensors for clinical diagnosis, including detection of cancer and disease biomarkers and in vivo molecular imaging. We then conclude with a discussion on the advanced development and challenges of aptasensors.

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Section: Aptasensors For Detection Applicationsmentioning

confidence: 99%

Section: Aptasensors For Detection Applicationsmentioning

confidence: 99%