Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor

Holler, Stephen; Dantham, Venkata Ramanaiah; Keng, D.; Kolchenko, V.; Arnold, Stephen

doi:10.1117/12.2050222

Cited by 5 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using this technique, the researchers have reported the detection of proteins as small as 5 kDa, and this technique also has the potential to screen cancer biomarkers that are in the range of 50-300 kDa. 20 Another interesting approach to increase sensitivity is to use liquid spheres in the form of droplets as WGM resonators. Liquid droplets produce sharp WGM resonances and can serve as both the sample and optical cavity simultaneously.…”

Section: Microspherementioning

confidence: 99%

“…One method to increase surface area is to surround the sphere with gold nanoparticles such that it acts as nanoscopic antennas. 20 Amplifying the sphere's surface area also amplifies the output signals. Progress in understanding the surface chemistry or functionalization techniques and thus improving accuracy of the microsphere biosensors via increasing the number of accessible binding sites would also be another method of increasing sensitivities.…”

Section: Conclusion and Future Trendsmentioning

confidence: 99%

See 1 more Smart Citation

Optical-resonator-based biosensing systems: current status and future prospects

Nordin¹

2016

NDD

View full text Add to dashboard Cite

Optofluidic devices have emerged as a promising label-free method for sensitive detection of biological molecules. Its advantages of rapid analysis, high specificity, and low interactions with samples have made it a popular device for biological and chemical analyses. This mini review describes state-of-the-art optofluidic devices based on optical resonators for biosensing. Advanced optical resonator geometries such as microspheres, microrings, and their integration with fluidics have been described. It is predicted that to meet demands of disease diagnostics for multiple clinically relevant samples, sizes of optical resonators will shrink further and geometries that enable multiplexing and integration with signal processing will be the trend of the future.

show abstract

Section: Microspherementioning

confidence: 99%

Section: Conclusion and Future Trendsmentioning

confidence: 99%

Optical-resonator-based biosensing systems: current status and future prospects

Nordin¹

2016

NDD

View full text Add to dashboard Cite

show abstract

“…Significant progress has been made in their use in biodetection, especially in a wide analytes range [2,[7][8][9][10][11][12][13][14][15][16][17] and in dynamics studies [12,14,17]. Their detection range includes single molecules [10,18], proteins [2,10,11,19,20], DNA [7,18,21], viruses [17], cells [9], nano-or micro-objects [8,22], and even membrane objects [3,9,23]. Song fabricated a spiral microdisk that could detect a nanoparticle approaching distance, and provided numbers and sizes via a chiral resonance [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Facile microfluidic fabrication of monodispersed self‐coupling microcavity with fine tunability

Zhang

Liu

et al. 2019

Electrophoresis

View full text Add to dashboard Cite

Whispering gallery mode (WGM) resonators have received extensive attention because of their nonlinear optical application in lasers and sensors. Optical microcavities are excellent candidates for constructing powerful microlasers and label‐free biosensors, owing to their low optical losses and small size. However, most of these microcavity syntheses rely on sophisticated fabrication methods and cannot be manipulated easily. To achieve facile and versatile microcavity fabrication, we present a robust microfluidics method for monodispersed self‐coupling optical microcavity fabrication with a fine tunability. The microcavity polydispersity was less than 3%. The optical microcavity size could be varied from 10 to 30 µm with a steady quality factor (Q) of approximately 1000. The lowest laser threshold that we obtained was 0.82 µJ with a microcavity size of 20 µm. The doped fluorescent dye concentration can be tuned precisely from 0.001 to 0.05 wt% to explore an optimized fluorescent background. The experimental results and theoretical simulation match well in terms of Q and the electrometric resonance field intensity. Compared with previous precise and practical fabrication methods, we have demonstrated a facile approach for versatile optical microcavity fabrication. This method can vary the microcavity materials, size, doped fluorescent dye concentration, WGM resonance spectrum, Q factor, and laser threshold easily to adapt to various circumstances and specific applications.

show abstract

“…There are many sensors that can work in almost real time and do not require use of reagents, but they typically measure refractive index and are based on ring-resonators [23][24][25][26], photoniccrystals [15][16][17][18][19][20][21], whispering gallery-mode [22][23][24], plasmonic structures [25] and other optical components, that without additional modifications do not provide enough specificity for differentiation between multiple drugs. In addition, these techniques are prone to noise caused by any microscale particles present in the system and are very sensitive to small temperature changes.…”

Section: Introductionmentioning

confidence: 99%

Optofluidic spectroscopy integrated on optical fiber platform

Archibong

Stewart

Pyayt

2015

Sensing and Bio-Sensing Research

View full text Add to dashboard Cite

a b s t r a c t Administering a wrong drug or a wrong dose can be extremely dangerous and can result in severe adverse effects or even the death of a patient. With human errors being possible, automatic real time identification of a drug and its concentration using technology is a viable option to decrease the chance of incorrect drug administration. As a step toward this goal, we propose a new optical fiber based spectroscopic system that has built-in filtration capabilities and thus can work in real time near patient without additional sample pre-processing. It is designed as a point probe consisting of an optical fiber with a miniature filtering reflector integrated on the interface. In the future it can be inserted into a bag for intravenous therapy (IV therapy) or in a syringe to measure the spectrum of the fluid and to confirm its properties. Additionally, use of microfluidic filtration allows to remove microscopic particles from the sample and thus decreases the noise and increases the sensitivity of spectroscopic measurement. In this study, an optofluidic system was fabricated, and filtration capabilities and measurement of cobalamin (vitamin B 12 ) concentration have been demonstrated. Ó 2014 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/3.0/).

show abstract

Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor

Cited by 5 publications

References 16 publications

Optical-resonator-based biosensing systems: current status and future prospects

Optical-resonator-based biosensing systems: current status and future prospects

Facile microfluidic fabrication of monodispersed self‐coupling microcavity with fine tunability

Optofluidic spectroscopy integrated on optical fiber platform

Contact Info

Product

Resources

About