Optical-resonator-based biosensing systems: current status and future prospects

Nordin, Anis Nurashikin

doi:10.2147/ndd.s70385

Cited by 14 publications

(3 citation statements)

References 52 publications

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“…An optical resonator is designed to allow light waves at specific (resonant) frequencies to be confined and stored within [ 17 , 27 , 28 ]. Light waves continuously travel back-and-forth in between two or more interfaces or circulate within the optical resonator structure.…”

Section: Optical Resonator-based Biosensorsmentioning

confidence: 99%

Label-Free Optical Resonator-Based Biosensors

Rho

Breaux

Kim

2020

Sensors

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The demand for biosensor technology has grown drastically over the last few decades, mainly in disease diagnosis, drug development, and environmental health and safety. Optical resonator-based biosensors have been widely exploited to achieve highly sensitive, rapid, and label-free detection of biological analytes. The advancements in microfluidic and micro/nanofabrication technologies allow them to be miniaturized and simultaneously detect various analytes in a small sample volume. By virtue of these advantages and advancements, the optical resonator-based biosensor is considered a promising platform not only for general medical diagnostics but also for point-of-care applications. This review aims to provide an overview of recent progresses in label-free optical resonator-based biosensors published mostly over the last 5 years. We categorized them into Fabry-Perot interferometer-based and whispering gallery mode-based biosensors. The principles behind each biosensor are concisely introduced, and recent progresses in configurations, materials, test setup, and light confinement methods are described. Finally, the current challenges and future research topics of the optical resonator-based biosensor are discussed.

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Section: Optical Resonator-based Biosensorsmentioning

confidence: 99%

Label-Free Optical Resonator-Based Biosensors

Rho

Breaux

Kim

2020

Sensors

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“…Fabry-Perot interferometer [7], optical coupler [8], and surface plasmon resonance sensor [9]. Among them, optical resonator sensors detect changes in the external effective refractive index by measuring the shift in resonant wavelength peaks due to changes such as antigen-antibody reactions, temperature changes, and protein binding in the sensing region [10].…”

Section: Introductionmentioning

confidence: 99%

Thermal Reflow Effect in Multi-Mode Waveguide of S-Bend Resonator With Mode Discrimination

et al. 2022

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Polymer-based S-bend optical resonator consisting of multi-mode waveguide has been used as refractive index sensing devices due to their cost-effectiveness and ease of fabrication. However, during fabrication, the thermal reflow that occurs during the baking process and overdevelopment induces an inclination in the sidewalls of the waveguide. The construction of the angled sidewalls can influence the propagation mode properties of the waveguide, such as the evanescent field and loss. Hence, in this study, we designed and analyzed S-bend resonators to investigate the influence of the sidewall slope on the optical modes of the waveguide and the sensing performance of the resonator with respect to the variation of slope angles. The simulation results revealed that, as the sidewall slope deviated from the right angle (90°-65°), the sensitivity of the device increased by a factor of 1.8 due to the field leakage, whereas, the extinction ratio and Q-factor decreased by 54% and 37%, respectively. The results indicated that the sidewall slope induces a trade-off between the resolution and the sensitivity of the S-bend resonator. The findings of this study can be used as a reference for further research on MMW-based optical sensors using polymer materials.

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“…Optical micro-resonators are extensively investigated as a promising label-free biosensing tool for applications in medical diagnosis, environmental monitoring and homeland security [1], [2]. In these micro-resonators, the evanescent fields of the resonant light are utilized to probe the surface mass loading or the refractive index (RI) change caused by the presence of analytes in the surrounding medium.…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh Q Polymer Microring Resonators for Biosensing Applications

Chen

Song

et al. 2019

IEEE Photonics J.

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The capability of an ultrahigh Q polymer microring resonator as a biosensing system is systematically investigated. By optimizing the device design and fabrication process, the device operates in the slightly under-coupled regime with a record intrinsic Q factor of 8.0 × 10 5 , which offers a high sensitivity and low detection limit. In surface mass detection, a surface mass density of 12.7 pg/mm 2 of bovine serum albumin is detected due to the physical adsorption. The noise-equivalent detection limit is approximately 5.3 pg/mm 2 in a wavelength-shift scheme and 55.9 fg/mm 2 in an intensity-variation scheme. These results show that the best sensing performance with the on-chip polymer ring resonator system is achieved.

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Optical-resonator-based biosensing systems: current status and future prospects

Cited by 14 publications

References 52 publications

Label-Free Optical Resonator-Based Biosensors

Label-Free Optical Resonator-Based Biosensors

Thermal Reflow Effect in Multi-Mode Waveguide of S-Bend Resonator With Mode Discrimination

Ultrahigh Q Polymer Microring Resonators for Biosensing Applications

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