Labeling of Biomolecules for Medicinal Applications—Bioorganometallic Chemistry at Its Best

Functionalised Tris(pyrazolyl)methane Ligands and Re(CO)3 Complexes Thereof

“…[1][2][3] Several groups are developing ligands for the radio-labelling of bio-molecules. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Many of these ligating moieties are based upon bis(pyridylmethyl)amine derivatives and we have also developed a N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer with bis(pyridylmethyl)amine derivatives as metal binding sites.…”

From hydrolytically labile to hydrolytically stable RuII–arene anticancer complexes with carbohydrate-derived co-ligands

“…In recent years many examples of organometallic compounds appeared that exhibit potent anticancer activity [1][2][3][4], including compounds that selectively inhibit enzymes [5][6][7][8][9], block receptors [2], or have been used to label peptides or other biomolecules [10,11]. Indeed, titanocene dichloride, Cp 2 TiCl 2 , entered clinical trials as an anticancer agent [12,13], and other compounds are expected to follow.…”

Stability, protein binding and thiol interaction studies on [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt

“…Ethinylestradiol was one of the first bioactive molecules coordinated to Co 2 (CO) 6 . This complex can be used as marker in the socalled carbonyl-metallo-immuno-assay and is known to inactivate the estrogen receptor (Vessieres et al 1992;Metzler-Nolte 2001).…”