Keywords: Carbon monoxide / Carbonyl ligands / Polymer conjugates / Manganese / EPR effect / Cytotoxicity CO-releasing molecules (CORMs) were coordinated to polymeric carrier systems for passive transport to tumour tissue or sites of inflammation, as described by the enhanced permeability and retention (EPR) effect. The developed conjugates consist of an organometallic fac-Mn(CO) 3 fragment, which is bound to a methacrylate or methacrylamide polymer backbone by bis(pyridylmethyl)amine-type ligands. The resulting Mn(CO) 3 -polymer conjugates were investigated as photoinducible CO-releasing molecules (photoCORMs). Furthermore, three model complexes [LMn(CO) 3 ]O 2 SCF 3

Diagnosis of early stage angiogenic tumours is fundamental for cancer therapy. In this study we present the synthesis and characterisation of functionalised HPMA‐copolymers with optimal molecular weights that meet the demands of the enhanced permeability and retention (EPR) effect. Rhenium tricarbonyl complexes of the tripodal ligands bis(2‐pyridylmethyl)benzylamine (1a) and bis(2‐pyridylmethyl)‐4‐vinylbenzylamine (1b) were prepared and characterised by 1H NMR and IR spectroscopy, mass spectrometry and X‐ray diffraction. Ligand 1b was copolymerised with N‐(2‐hydroxypropyl)methacrylamide (HPMA), and the resulting copolymer was treated with (nBu4N)2[Re(CO)3Br3] to yield a Re(CO)3‐labelled copolymer.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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Sandwich gewünscht? Reduktion von 1,1′‐Bis(o‐carboran) und anschließende Reaktion mit einer Quelle für {Ru(p‐Cymol)}2+‐Fragmente bei Raumtemperatur lieferten eine unsymmetrisch verbrückte Spezies als Folge einer C‐C‐Bindungsspaltung in p‐Cymol. Nach DFT‐Rechnungen ist das Aren zwischen zwei Ru‐Atome als Teil eines Metallacarborans eingeschlossen (siehe Bild; C grau, B gelb, Ru rot), und die Reduktion erfolgt durch den zweiten Carboranrest.

The cover picture shows the structure of a fluorescent polymer consisting of a ligand‐functionalised polylactide coordinated to Re(CO)3(phen). This polymer can passively target cancer tissue and transport the fluorescent dye to the cancer cell membranes, where it can be detected by fluorescence microscopy, which enables early detection of cancer. The resulting fluorescence in the membranes of A2780 cells can be seen in the background. Details are discussed in the article by P. C. Kunz et al. on p. 5063 ff.