Polymer Conjugates of Photoinducible CO‐Releasing Molecules

Abstract

Keywords: Carbon monoxide / Carbonyl ligands / Polymer conjugates / Manganese / EPR effect / Cytotoxicity CO-releasing molecules (CORMs) were coordinated to polymeric carrier systems for passive transport to tumour tissue or sites of inflammation, as described by the enhanced permeability and retention (EPR) effect. The developed conjugates consist of an organometallic fac-Mn(CO) 3 fragment, which is bound to a methacrylate or methacrylamide polymer backbone by bis(pyridylmethyl)amine-type ligands. The resulting Mn(CO) 3 -polymer conjugates were investigated as photoinducible CO-releasing molecules (photoCORMs). Furthermore, three model complexes [LMn(CO) 3 ]O 2 SCF 3

Carbon monoxide – physiology, detection and controlled release

“…The resulting Mn(CO) 3 -polymer conjugates were investigated as photoinducible CO-releasing materials (photoCORMAs). 193 In general, NO- and CO-releasing materials (NORMAs & CORMAs) with NO and CO photodonors can retain toxic metabolites after gas release in the biocompatible polymer matrix. 194 The concept of embedding water-insoluble, photoactive NO metal complexes into nanoparticles 195 and fibrous polymer non-wovens 196 has been transferred to phototriggerable metal carbonyls (Fig.…”

A Comparative Study of Tricarbonylmanganese Photoactivatable CO Releasing Molecules (PhotoCORMs) by Using the Myoglobin Assay and Time‐Resolved IR Spectroscopy

“…[6,18] All compounds investigated do not release CO in the dark. [12] 9 4-tipo iPr 27 0.96 [12] 10 bpma 20 1.59 [19] 11 bpmea 20 2.65 [19] 12 Bpmvba 20 1.65 [19] The steric bulk of the N,N,N ligand seems to determine both n CO as well as t 1/2 .…”

Design of biomaterials for intracellular delivery of carbon monoxide

“…7b). 60 The t 1/2 for CO release was found to be 20 min under 365 nm light exposure. Composites with molecular weights below approximately 50 kDa did not show any cytotoxicity in HepG2 cells.…”

“…These scaffolds are expected to accumulate passively and selectively in tumor tissues as a result of the enhanced permeability and retention effect. 60,61 Smith et al modified dendritic scaffolds with a [MnBr(bpy)-(CO) 3 ] moiety to obtain CO-releasing metallodendrimers (Fig. 7a).…”

“…Tissue-targeting materials. Unlike the micelle-and NP-based carriers of CORMs, dendrimers, 59 copolymers, 60 and porous materials [61][62][63] have been utilized as tissue-targeting scaffolds. These scaffolds are expected to accumulate passively and selectively in tumor tissues as a result of the enhanced permeability and retention effect.…”