Labeling of diazepam with iodine-131

Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

“…It is worth noting that radioiodinated ( 123 I, 125 I or 131 I) benzodiazepinones have been widely used in binding assays 13 . The strategies used in the synthesis of these radioiodinated benzodiazepinones always involve an isotopic exchange with Na 125 I, the parent iodinated compound being synthesized from simple iodinated precursors such as iodobenzoic acid 22 23 24 .…”