Labeling of omeprazole with technetium-99m for diagnosis of stomach

Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection

“…Being a tissue‐rich with angiotensin II receptor subtype II, the kidney showed high‐radioactivity uptake and low clearance augmented by low‐water solubility of 125 I‐CAN, equal to 5, 13, 30, and 21 at 5, 15, 30, and 60 minutes, respectively. A similar profile between liver and intestine was observed indicating some enterohepatic circulation . Results of the radioactive uptake of both kidney and liver are compatible with data published by Sidiqui et al who mentioned that the main elimination route of mother drug CAN is through hepatobiliary and urinary pathways .…”

Radioiodination and biological evaluation of nizatidine as a new highly selective radiotracer for peptic ulcer disorder detection

“…(Figure A) more than in the case of normal stomach and was confirmed by gamma camera analysis (see Figure ). The published %ID/g ± SD for a number of common of proton pump inhibitors, eg, [ 99m Tc]pantoprazole, [ 99m Tc]omeprazole, [ 99m Tc]rabeprazole, [ 125 I]iodofamotidine, [ 125 I]iodoomeprazole, and [ 131 I]iodorabeprazole, shows a maximum uptake in stomach ulcer of 27.2% ID/g at 30 minutes, 22.0% ID/g at 1 hour, 33.4% ID/g at 30 minutes, 65.9% ID/g at 30 minutes, 47.3% ID/g at 4 hours, and 38.00% at 1 hour, respectively. Our results indicate that iodonizatidine has a higher %ID/g ± SD value than these materials have.…”

“…The simplest method for inducing stomach ulcer in laboratory animals was made by dosing 1 mL of acidified (HCl) ethanol (1:10 v/v) using gastric tubes. After 2 to 4 hours, the stomach showed distension, and symptoms of ulcer appeared …”

“…Nizatidine, dimethyl[(4‐{[(2‐{[1‐(methyl amino)‐2‐nitro ethenyl] amino}ethyl) sulfanyl] methyl}‐1,3‐thiazol‐2‐yl) methyl]amine, is a histamine H 2 ‐receptor antagonist, which can inhibit the production of stomach acid, and is used in the treatment of peptic ulcer disease and gastroesophageal reflux . Many proton pump inhibitors such as [ 99m Tc]pantoprazole, [ 99m Tc]omeprazole, [ 99m Tc]rabeprazole, and [ 125 I]iodorabeprazole have been used to image stomach ulcers. Iodine 123 is the isotope of choice for medical imaging with a half‐life to 13.22 hours and decays by emission of gamma radiation with an energy of 159 keV.…”

Radioiodination and biological evaluation of irbesartan as a tracer for cardiac imaging

“…Table 1 shows the biodistribution of radio-IodoIrbesartan in different body organs and fluids. All radioactivity levels are expressed as average percent-injected tissue (%ID/ gram ± S.D) [25][26][27][28]. Low thyroid uptake at all times indicated that the of [ 125 I]IodoIrbesartan was relatively stable in vivo [21][22][23][24].…”