Labor induction with prostaglandin E1 misoprostol compared with dinoprostone vaginal insert: A randomized trial

Sánchez-Ramos, Luis; Peterson, Dirk E.; Delke, Isaac; Gaudier, Francisco L.; Kaunitz, Andrew M.

doi:10.1016/s0029-7844(97)00673-x

Cited by 104 publications

(41 citation statements)

References 17 publications

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“…The standardized cervical priming and induction of labor are predominantly achieved by means of PG administration. However, in the recent years, there has been a considerable interest in the use of misoprostol [3][4][5] and NO donors [6,7] for cervical ripening and labor induction.…”

Section: Introductionmentioning

confidence: 99%

Isosorbide Mononitrate a Nitric Oxide Donor: A Study of Its Efficacy and Safety as an Agent for Cervical Ripening

Dave

Nigam

Maru

2014

J Obstet Gynecol India

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Objective To study the efficacy and safety profile of isosorbide mononitrate (IMN) as an agent for cervical ripening. Methodology This study was conducted in the Department of Obstetrics and Gynecology, M Y Hospital & M G M Medical College Indore from September 2011 to February 2013. Pregnant women attending the antenatal clinics were screened for possible participation in the study after explaining the nature of the study. This study was conducted on 150 patients. An initial dose of 40 mg IMN was applied in the posterior vaginal fornix, and the same dose was repeated after 6 h. Cervical ripening was assessed by the change in Bishop Score 12 h after the initial application.Results In a study of 150 cases, mean maternal age was 22.2 ± 2.6 years (range 19-35 years) and mean gestational age was 40.5 ± 1.07 (range 40-42 weeks). 52 women were primigravidas, while 98 were multigravidas. The mean Bishop Score-before drug administration was 1.94 ± 1.3 (range 0-5), and mean fetal heart rate was 137 ± 6.2 bpm. The mean of Bishop scores before IMN administration was 1.94 ± 1.3, while mean of Bishop score after drug administration was 6.7 ± 2.2; mean difference was equal to 4.76. P value was equal to 0.0001. By conventional criteria, this difference is considered to be statistically significant. The mode of delivery 96 (64 %) delivered vaginally, while 54 (36 %) were delivered by Cesarean section. Mean Apgar score at 1 min was 8.2 ± 0.9 SD (range 7-10), while mean Apgar score at 5 min was 9.4 ± 0.6 (range 8-10). The only side effect noted was headache, and 30 cases (20 %) complained of headache. 123Conclusion IMN seems to be effective, safe, inexpensive, and well-tolerated agent for cervical ripening. It is cost effective and safe with minimal side effects.

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Section: Introductionmentioning

confidence: 99%

Isosorbide Mononitrate a Nitric Oxide Donor: A Study of Its Efficacy and Safety as an Agent for Cervical Ripening

Dave

Nigam

Maru

2014

J Obstet Gynecol India

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“…8 Nearly 50.86% of cases were beyond 41weeks of gestation & 47.42% were term pregnancies (between 37-40 weeks of gestation) as shown in Table 1. Literature shows that prolonged pregnancy (40%) is the commonest indication, next common is PIH (13%) and the third common is PROM (4%).…”

Section: Discussionmentioning

confidence: 99%

Study of induction of labour with vaginal misoprostol in a tertiary hospital in a rural area of Telangana, India

Kothapally

Kavati

Bongu

2015

Int J Reprod Contracept Obstet Gynecol

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“…[6] Sanches-Ramos L et al, too found higher CS rate in Misoprostol group (22.2% versus 13%). [14] Regarding induction-delivery interval, Sahu L et al and Fernandez E et al found it to be shorter in Misoprostol group. [15,16] Similar result was seen from our study.…”

Section: Discussionmentioning

confidence: 99%

Induction of Labour by Intravaginal Misosprostol and Intracervical Dinoprostone: A Comparative Study

Th¹,

Sanaton²

2018

AIMDR

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Background: Induction of labour is indicated when the benefits to either the mother or foetus outweigh those of continuing the pregnancy. Many drugs or methods have been tried for the purpose, the latest addition being prostaglandins. Objective: The present study was taken up to compare the safety and efficacy of 50 µg intra-vaginal Misoprostol and a single dose of 0.5 mg intra-cervical Dinoprostone in induction of labour. Methods: 220 women admitted in RIMS during the period Jan 2003-Aug 2004 and needing induction of labour were randomly allocated into two groups, each group consisting of 110 women. To one group Misoprostol was given while the other group got Dinoprostone. These two groups were followed up up-to the perinatal period. Result: The mean Bishop's score at 4th hour were found to be significantly increased in both the groups, the mean score at 4th hour being significantly higher in Misoprostol group as compared to Dinoprostone group (5.77 Vs 4.83). The need for oxytocin augmentation was significantly less in Misoprostol group. The induction-delivery period was also found to be much shorter in this group when compared to Dinoprostone group (10.8±4.8 hours Vs 12.0±7.7 hours). The proportion of vaginal delivery was comparable in the two groups. Apgar scores of babies in the two groups also were comparable. Maternal and perinatal complications were very less in both the groups. Conclusion: Both intra-vaginal Misoprostol and intra-cervical Dinoprostone were found to be effective and safe for induction of labour. However, Misoprotol is less expensive, easy to administer and more effective than Dinoprostone with minimal side effects when cases are monitored properly.

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Labor induction with prostaglandin E1 misoprostol compared with dinoprostone vaginal insert: A randomized trial

Abstract: Intravaginal misoprostol and the dinoprostone vaginal insert appear to be safe agents for cervical ripening and labor induction. However, misoprostol is less expensive and more effective than the dinoprostone vaginal insert.

Cited by 104 publications

References 17 publications

Isosorbide Mononitrate a Nitric Oxide Donor: A Study of Its Efficacy and Safety as an Agent for Cervical Ripening

Isosorbide Mononitrate a Nitric Oxide Donor: A Study of Its Efficacy and Safety as an Agent for Cervical Ripening

Study of induction of labour with vaginal misoprostol in a tertiary hospital in a rural area of Telangana, India

Induction of Labour by Intravaginal Misosprostol and Intracervical Dinoprostone: A Comparative Study

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