Laboratory and clinical profile of dengue: A study from Mumbai

Abstract

Background: Dengue an endemic disease in most subtropical and tropical regions of the world is causing severe epidemics in India. An alarming rise of dengue has also been seen in Mumbai, during the recent years. Aim and Objective: The study was conducted to know the prevalence of dengue infection, based on laboratory rapid screening tests for IgM and IgG antibodies and the confirmatory IgM ELISA test and to study the seasonal variation and the clinical profile in these cases. Material and Method: A retrospective study of laboratory test results and clinical profile of suspected dengue cases was carried out in a tertiary care hospital over a period between January 2004 and November 2007. Result: Of the 3 677 samples processed by rapid test for antibodies against dengue (Denguchek), 503 (13.67%) gave positive results. Fifty-six samples (26.41%) were positive by IgM Enzyme linked immunosorbent assay (ELISA) test, of 212 rapid positive samples processed by ELISA test. Our study comprised of 315 adult and 188 pediatric cases. The common symptom of dengue was fever, icterus, myalgia, and headache. Thrombocytopenia (platelet counts <75 000/cmm) was seen in 386 (76.74%) cases. Seventy-seven cases (15.30%) positive by rapid screening tests for dengue antibodies were also positive for IgM/ IgG antibodies against Leptospira by Dridot test (Rapid test). Of these, 49 (63.64%) were confirmed to be positive for dengue antibodies by the ELISA test. Conclusion: As dengue causes increased morbidity and mortality and requires prompt diagnosis and treatment for the proper management of these cases, the rapid screening test for IgM/IgG antibodies helps clinicians toward achieving this goal.

Dengue: a clinical & hematological study

“…All patients in our study presented with fever on admission. Similar observation were found in other studies [13][14][15][16][17][18]. Retroorbital pain is considered a hallmark of Dengue fever.…”

“…Headache was present among all our patients (100%).In other studies, the incidence of headache was as follows, Raju [15,16,17,19,20]. Our study differed from most of the other studies as headache was not a prominent symptom in those studies.…”

“…Some authors showed similar observations [4,7,9]. Others were observed slightly lower percentage of myalgia [14,16,20].…”

“…Saquib MA et al in their study reported an incidence of 93% of thrombocytopenia in their study involving 556 seropositive patients during the 2011 dengue fever epidemic in Lahore, Pakistan [13]. Turbadkar reported an incidence of 76.74% of thrombocytopenia [16]. Kariyawasam S et al reported a 100% incidence of thrombocytopenia in their study involving 15 pregnant patients who were seropositive for DF [18].…”

Dengue infection in central India: a 5 years study at a tertiary care hospital

“…Similar findings were reported by Turbadkar D et al who observed that fever was the major presenting complaint followed by icterus in 25.8%, myalgia in 25% and headache in 13.9% in the suspected cases of dengue. 21 Mandal SK et al also reported fever in all cases followed by headache (62.16%), rash (37.84%) and bleeding (13.51%). They also observed ascites in 8.1%, pleural effusion in 18.91% and neurological features in 11.11% cases.…”