Laboratory and Field Evaluation of Five Repellents Against the Black Flies Prosimulium mixtum and P. fuscum (Diptera: Simuliidae)

Robert, Leon L.; Coleman, Russell E.; LaPointe, Dennis A.; Martin, Philip E.; Kelly, Rose M.; Edman, John D.

doi:10.1093/jmedent/29.2.267

Cited by 16 publications

(6 citation statements)

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“…AI3Ð37220 (220) contains two asymmetric centers and achiral synthesis yields a racemic mixture of 1S,2ЈR, 1R,2'S, 1R,2ЈR, and 1S,2'S stereoisomers. The racemic mixture proved to be an effective repellent against a variety of blood-feeding arthropods (Robert et al 1992, Coleman et al 1993, Walker et al 1996, Frances et al 1996, Frances et al 1998 This article reports the results of research only. Mention of a proprietary product does not constitute an endorsement or a recommendation by the USDA or the Department of Defense for its use.…”

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Synthesis and Repellent Efficacy of a New Chiral Piperidine Analog: Comparison with Deet and Bayrepel Activity in Human-Volunteer Laboratory Assays Against Aedes aegypti and Anopheles stephensi

Klun

Khrimian

Margaryan

et al. 2003

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Optically active (1S,2'S)-2-methylpiperidinyl-3-cyclohexen-1-carboxamide (SS220) is a new synthetic arthropod repellent. A three-step synthesis based on a chiral Diels-Alder reaction and diastereomeric resolution of 2-methylpiperidine was developed to prepare the compound. Quantitative laboratory assays using human volunteers compared the effectiveness of SS220 with the commonly used repellents Deet and Bayrepel against Aedes aegypti (Linnaeus) and Anopheles stephensi Liston mosquitoes. In two experiments using Aedes aegypti, one using a single identical dose and one with varying doses used to develop a dose-response curve, SS220 was as effective as Deet and both compounds were more effective than Bayrepel. The three compounds were equally effective against An. stephensi. Based on the ease of its synthetic preparation and its repellent efficacy, we surmise that SS220 is a candidate to serve as a new and effective alternate repellent for protection against arthropod disease vectors.

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Synthesis and Repellent Efficacy of a New Chiral Piperidine Analog: Comparison with Deet and Bayrepel Activity in Human-Volunteer Laboratory Assays Against Aedes aegypti and Anopheles stephensi

Klun

Khrimian

Margaryan

et al. 2003

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“…In IPM programs related to animal and human health, DEET and other synthetic repellents have been used extensively against mosquitoes [274][275][276][277][278][279][280][281][282][283][284][285][286], against blackflies [287], and against ticks [288]. Recently, the use of natural products as insect repellents has had renewed interest as well.…”

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confidence: 99%

Application of Semiochemicals in Integrated Pest Management Programs

Bjostad

Hibbard

Cranshaw

1993

ACS Symposium Series

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Chemical communication is important in the life cycles of many insect species, principally for the location of mates and food. Structural identification and synthesis has been carried out for many semiochemicals, and a number of techniques have been developed to use these compounds as components of integrated pest management (IPM) programs. Semiochemicals have two main uses in IPM programs: monitoring insect pest populations and preventing agricultural damage by interfering with insect behavior. Pheromones are perhaps the most widely exploited semiochemicals at present, but recent efforts have extended increasingly to the identification and use of compounds involved in interspecific exchange of information as well.The use of semiochemicals to manipulate insect behavior has proved to be one of the most useful components of integrated pest management (IPM) programs. Semiochemicals are compounds that are emitted or displayed by one organism and that affect the behavior of another organism [/]. Perhaps the most important semiochemicals used by insects are those involved in locating mates and food, and at present these are the kinds of semiochemicals most widely exploited for insect control. Semiochemicals with many other kinds of ecological roles have also been characterized in insects, such as compounds that function as warnings, or compounds that mediate the collective activity of many partners in completing large tasks. A number of major reviews of the use of semiochemicals in IPM programs have appeared [7][8][9], as well as a critical review of semiochemical utility in general [10], An extensive list of companies that offer semiochemical lures, traps designed for semiochemical monitoring, and commercial systems for behavioral pest control has been compiled by Inscoe [11].Practical applications of semiochemicals in agriculture fall into two main categories, population monitoring and behavioral pest control. The main use at present is in monitoring insect pests with traps baited with semiochemicals, as a part of making decisions about pesticide application or other control techniques. A second use of semiochemicals is the direct prevention of insect damage by a variety of techniques, including the placement of a large number of semiochemical sources that disrupt the behavior of the insects, mass trapping, attracticides (insecticide lures), and enhancement of parasitoid activity.

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“…Robert et al (1992) found 220 and 765 were more effective than deet in laboratory and Þeld evaluations against black ßies. Initial sensitivity tests of these piperidine compounds and deet against Anopheline mosquitoes and Phlebotomine sand ßies (Coleman et al 1993) showed that 220 and 765 were as effective as deet.…”

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Optically Active Arthropod Repellents for Use Against Disease Vectors

Klun

Gupta

2000

J Med Entomol

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Optically inactive 1-[3-cyclohexen-1-ylcarbonyl] piperidine and 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine are repellents against blood-feeding arthropods. Pure stereoisomers of these compounds were synthesized and characterized for use in bioassays. Initial laboratory tests with the malaria vector Anopheles stephensi Liston showed that this species was repelled differentially by the stereoisomers of 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine. Two stereoisomers were twice as repellent as the other stereoisomers. These results indicate that stereoisomerism influences repellent efficacy in this class of compounds.

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Laboratory and Field Evaluation of Five Repellents Against the Black Flies Prosimulium mixtum and P. fuscum (Diptera: Simuliidae)

Cited by 16 publications

References 0 publications

Synthesis and Repellent Efficacy of a New Chiral Piperidine Analog: Comparison with Deet and Bayrepel Activity in Human-Volunteer Laboratory Assays Against <I>Aedes aegypti</I> and <I>Anopheles stephensi</I>

Synthesis and Repellent Efficacy of a New Chiral Piperidine Analog: Comparison with Deet and Bayrepel Activity in Human-Volunteer Laboratory Assays Against <I>Aedes aegypti</I> and <I>Anopheles stephensi</I>

Application of Semiochemicals in Integrated Pest Management Programs

Optically Active Arthropod Repellents for Use Against Disease Vectors

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