Laboratory diagnosis of late-onset male hypogonadism andropause

Clapauch, Ruth; Carmo, Aline Machado; Marinheiro, Lizanka Paola Figueiredo; Buksman, Salo; Pessoa, Isabel

doi:10.1590/s0004-27302008000900005

Cited by 7 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another longitudinal study, Liu et al found that the decline in serum testosterone and increase in SHBG with age were comparable across two separate regional Australian populations (11). The influence of age in the testosterone levels was confirmed by Clapauch et al in a study conducted in a cohort of 216 Brazilian men aged 52-84 years (17). In this study, a significant difference in the level of total testosterone was observed between patients < 60 years versus those aged 70 years or more.…”

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Age-related testosterone decline in a Brazilian cohort of healthy military men

et al. 2011

View full text Add to dashboard Cite

Introduction: Androgen decline in the aging man has become a topic of increasing clinical relevance worldwide, as the reduction in testosterone levels has been reported to be accompanied by loss of muscle mass, accumulation of central adiposity, impaired mobility and increase risk of bone fractures. Although well-established in studies conducted in developed countries, progressive decline in serum testosterone levels with age has been poorly investigated in Brazil. Aim: To determine the pattern of blood testosterone concentrations decline with age in a cohort of Brazilian healthy military men. Materials and Methods:We retrospectively reviewed data on serum testosterone measurements of healthy individuals that had undergone a routine check-up at the Military Biology Institute. Blood samples were obtained early in the morning, and total testosterone concentration was determined using a commercial chemoluminescent immunoassay. Mean values were analyzed in five age groups: ≤ 40, 41 to 50, 51 to 60, 61 to 70, and > 70 years. Main Outcome Measure: Mean total testosterone levels. Results: 1,623 subjects were included in the analysis; mean age was 57 years (24 to 87), and mean testosterone level was 575.5 ng/dL (25.0 to 1308.0 ng/dL). The evaluation of age-related changes in total testosterone levels revealed a progressive reduction in serum levels of this hormone with increasing age. Testosterone levels below 300 ng/dL were reported in 321 participants, a prevalence of nearly 20% in the study population. Conclusion:In agreement with other findings, a reduction of total testosterone levels with age was reported for healthy Brazilian men.

show abstract

Section: Discussionmentioning

confidence: 83%

“…In this study, a significant difference in the level of total testosterone was observed between patients < 60 years versus those aged 70 years or more. In addition to total testosterone, a significant difference in free testosterone levels was also observed between these two age groups (17).…”

Section: Discussionmentioning

confidence: 85%

Age-related testosterone decline in a Brazilian cohort of healthy military men

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Hypogonadism diagnosis was based in TT levels which may be misleading, as men with "normal" TT may have lower FT and BT. Thus, TT is a poor marker for aging male gonadal function (14), as well as for osteoporosis risk. Bioavailable E2, i.e., E2 not bound to SHBG, has been shown to decrease with age and not to be influenced by the body mass index (BMI), such as TT or total E2.…”

Section: Discussionmentioning

confidence: 99%

“…Colour was auto-referred. This sample has been previously studied in relation to prevalence, clinical (13) and laboratorial hypogonadism diagnosis (14). Hormonal evaluation was performed at the Andrology Sector of Hospital da Lagoa, Health Ministry, Rio de Janeiro.…”

Section: Methodsmentioning

confidence: 99%

Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

Clapauch¹,

Mattos²,

Silva³

et al. 2009

Arq Bras Endocrinol Metab

Self Cite

View full text Add to dashboard Cite

Objective: To study and establish sex hormone cutoff levels for osteoporosis risk in men over 50 years old. Methods: Case-control study of 216 men > 50 years, 110 with osteoporosis (O) and 106 with normal bone density (C). We measured estradiol (E2), sex hormone binding globulin (SHBG), total testosterone (TT) and albumin. Free testosterone (FT) and bioavailable testosterone (BT) were calculated through Vermeulen's formula. Results: There was no difference in TT between groups. Relative risks of osteoporosis were 1.89 for E2 < 37 pg/mL (p = 0.02); 1.91 for SHBG > 55 nmol/L (p = 0.019); 2.5 for FT < 7 ng/dL (p = 0.015); 2.7 for BT < 180 ng/dL (p = 0.0003). Conclusions:In men over 50 years old, TT was not indicative of osteoporosis risk while E2 < 37 ng/mL was. SHBG > 55 nmol/L, FT < 7 ng/dL and BT < 180 ng/dL can represent additional indications for osteoporosis screening in men over 50 years old. Arq Bras Endocrinol Metab. 2009;53(8):1020-5 Keywords Male osteoporosis; estradiol; testosterone; free estradiol; free testosterone; SHBG resumo Objetivo: Estudar e estabelecer pontos de corte dos hormônios sexuais para risco de osteoporose em homens após os 50 anos de idade. Métodos: Estudo caso-controle de 216 homens > 50 anos, 110 com osteoporose e 106 com densidade óssea normal. Foram dosados: estradiol (E2), globulina ligadora de hormônios sexuais (SHBG), testosterona total (TT) e albumina. Foram calculadas: testosterona livre (TLC) e testosterona biodisponível (TB) pela fórmula de Vermeulen. Resultados: Não houve diferença na TT entre os grupos. Os riscos relativos de osteoporose foram de 1,89 para E2 < 37 pg/mL (p = 0,02); 1,91 para SHBG > 55 nmol/L (p = 0,019); 2,5 para TLC < 7 ng/dL (p = 0,015) e 2,7 para TB < 180 ng/dL (p = 0,0003). Conclusões: Em homens acima de 50 anos, TT não indicou risco de osteoporose, mas E2 < 37 pg/mL sim. SHBG > 55 nmol/L, TLC < 7 ng/dL e TB < 180 ng/dL podem representar indicações adicionais para pesquisa de osteoporose em homens acima de 50 anos. Arq Bras Endocrinol Metab. 2009;53(8):1020-5 Descritores

show abstract

“…In principle, the combination of low blood levels of peripheral hormones and inadequately low levels of pituitary hormones (below the upper limit of the reference range) indicates hypopituitarism (30). Table 1 provides a summary of the attempts to evaluate the gonadotropic function.…”

Section: Clinical and Laboratory Characteristics Of Hypogonadismmentioning

confidence: 99%

Hypogonadism after traumatic brain injury

Hohl

Mazzuco

Coral

et al. 2009

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is the most common cause of death and disability in young adults. Post-TBI neuroendocrine disorders have been increasingly acknowledged in recent years due to their potential contribution to morbidity and, probably, to mortality after trauma. Marked alterations of the hypothalamic-pituitary axis during the post-TBI acute and chronic phases have been reported. Prospective and longitudinal studies have shown that some abnormalities are transitory. On the other hand, there is a high frequency (15% to 68%) of pituitary hormone deficiency among TBI survivors in a long term setting. Post-TBI hypogonadism is a common finding after cranial trauma, and it is predicted to develop in 16% of the survivors in the long term. Post-TBI hypogonadism has been associated with adverse results in the acute and chronic phases after injury. These data reinforce the need for identification of hormonal deficiencies and their proper treatment, in order to optimize patient recovery, improve their life quality, and avoid the negative consequences of non-treated hypogonadism in the long term. resumoO traumatismo cranioencefálico (TCE) é a causa mais comum de morte e incapacidade em adultos jovens. Desordens neuroendócrinas pós-TCE vêm sendo reconhecidas cada vez mais nos últimos anos devido à sua potencial contribuição para a morbidade e, possivelmente, mortalidade após trauma. Alterações acentuadas do eixo hipotálamo-hipófise foram documentadas nas fases aguda e crônica pós-TCE. Estudos prospectivos e longitudinais têm mostrado que algumas anormalidades são transitórias. Por outro lado, existe uma elevada frequência de deficiências hormonais hipofisárias a longo prazo entre os sobreviventes de TCE, que varia de 15% a 68%. Hipogonadismo pós-TCE é um achado comum a longo prazo e estima-se que, em média, 16% dos sobreviventes sejam afetados. Hipogonadismo pós-TCE tem sido associado a resultados adversos tanto na fase aguda quanto na fase crônica após a lesão. Esses dados reforçam a necessidade da identificação e adequado tratamento das deficiências hormonais, para otimizar a recuperação do paciente, melhorar a qualidade de vida e evitar as consequências negativas a longo prazo do hipogonadismo não tratado. Arq Bras Endocrinol Metab. 2009;53(8):908-14

show abstract

Laboratory diagnosis of late-onset male hypogonadism andropause

Cited by 7 publications

References 44 publications

Age-related testosterone decline in a Brazilian cohort of healthy military men

Age-related testosterone decline in a Brazilian cohort of healthy military men

Total estradiol, rather than testosterone levels, predicts osteoporosis in aging men

Hypogonadism after traumatic brain injury

Contact Info

Product

Resources

About