Laboratory evaluation of cases of meningitis attending a tertiary care hospital in India: An observational study

Adhikary, Moumita; Chatterjee, R.

doi:10.4103/2231-0738.114861

Cited by 6 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deaths in similar profile of patients had been reported in other studies. 21,22 No relation with any isolated pathogens in this series could be traced which were successfully ascertained in two studies by Madhumita P. et al 6 2014 and Moumita Adhikary et al 16 2013. CSF specimen from such patients in those studies maximally yielded L. monocytogenes in culture but the provisions for isolation of this microorganism was not available in our set up.…”

Section: Discussionmentioning

confidence: 71%

“…CSF specimen from such patients in those studies maximally yielded L. monocytogenes in culture but the provisions for isolation of this microorganism was not available in our set up. The studies of Madhumita P. et al 6 2014 and Moumita Adhikary et al 16 . 2013 reported maximum mortality in their series with Neisseria meningitidis infection.…”

Section: Discussionmentioning

confidence: 98%

“…Similar correlation was also reported in other studies. 5,9,11,16,17 The chances of recovery of bacteria in CSF goes up to 100-fold, if the CSF sample can be intensified by replacing conventional centrifugation with cytospin centrifugation 11,18 and this was used in the present study. Majority of the isolates (68.18%) displayed a cell count ranging from 1001 to 5000/mm 3 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Bacteriological Profile of Patients With Acute Pyogenic Meningitis - A Hospital Based Study

Dey¹,

Nath²,

Bhattacharjee³

et al. 2016

jebmh

View full text Add to dashboard Cite

BACKGROUND Pyogenic meningitis is one of the most common infectious disease emergencies involving the central nervous system with higher incidence in developing countries than developed nations. Despite the large number of pathogens that have been reported to cause acute pyogenic meningitis, certain microorganisms are isolated with higher frequency depending on patient's age, immune status and geography. Present study was aimed to determine the trends in aetiology and spectrum of the bacteriological profile in adult patients with suspected pyogenic meningitis in NorthEast India. MATERIALS 50 CSF samples from as many patients of Acute Bacterial Meningitis over a period of one year were processed for cell counts, biochemical analysis, gram staining, culture, antigen detection by latex agglutination test and antibiotic susceptibility tests, as per standard techniques. OBSERVATION CSF cell counts showed neutrophilic predominance in all cases along with high protein and low sugar levels. 44% of the cases were culture positive and latex agglutination test was positive in 46.4% of the cases where culture was negative. S. pneumonia was the predominant pathogen identified in the present study in 12(24%) cases, followed by Pseudomonas and E. coli in 5(10%) cases each. Gram stain indicated the causative organisms in 68.2% of the culture positive cases. Among the culture negative patients gram stain indicated the causative organism in 3(10.7%) cases and these three cases were positive by LAT also. CONCLUSION Simple, rapid, inexpensive tests like gram staining remain significant means for diagnosis of acute pyogenic meningitis in developing countries. LAT goes a long way in identifying the organisms where the cultures are negative. This study thus paves the way for larger studies in this region for better recognition of the predominant organisms and the empirical antibiotic regimens.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bacteriological Profile of Patients With Acute Pyogenic Meningitis - A Hospital Based Study

Dey¹,

Nath²,

Bhattacharjee³

et al. 2016

jebmh

View full text Add to dashboard Cite

show abstract

“…CNS infections, especially pyogenic meningitis was found to be more common in males in the present study. The predominance for the male sex was also noted in the cases of pyogenic (bacterial) meningitis in Indian studies by Yadav et al, Adhikary et al 10,11 Fifty-five percent (n=37) of all the cases with CNS infections were from rural civilization. 56% (n=36) of the cases of meningoencephalitis were from rural civilization.…”

Section: Discussionmentioning

confidence: 74%

Burden of central nervous system infection in cases of fever with seizure and its association with outcome: an experience in a tertiary care center of Uttarakhand, India

Chand

Sharma

Rakholia

2019

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: CNS infections have been linked to adverse neurological sequelae notably seizures and mortality. Although, various etiologies of AFE have been studied, but the mystery still remains untangled for the substantial risk factors for the diagnosis and outcome.Methods: This prospective study was carried out on 67 children between 2 months to 15 years, from (May 2016 to April 2017) tertiary care centre of Uttarakhand. Patients were analysed for demographic variables, haematological parameters, CSF analysis, neuroimaging and their outcome was assessed at one month of follow up.Results: This study showed, 70% (n=47) of the cases presented in acute febrile encephalopathy. Most cases were diagnosed with pyogenic meningitis (40%, n=27) and More commonly occur during rainy season (39%; n=26) radiologically meningeal enhancement (28%; n=18) as the most common finding. Cases of acute febrile encephalopathy with GCS ≤5 had significant association with mortality. (Fischer exact value of 0.005; significant at p<0.05).Conclusions: Clinical signs of meningitis are not always reliable, and a laboratory support is required to reach early diagnosis hence. Pseudomonas and MRCONS were the major pathogens responsible for the bacterial meningitis among the paediatric age groups, hence antibiotic management should be planned intensively while culture reports are awaited. Cluster of cases with meningoencephalitis were found in rainy season hence suggested possible etiologies are JE/ Scrub/ Enterovirus. Mortality as well as morbidity was high in cases with acute encephalitis syndrome cause? JE/unknown etiology in this era for modern medicine hence vector control strategies be encouraged.

show abstract

“…[3] However, in different reports from India the overall incidence of meningitis varies from 12.12 to 56%, while the incidence of autoimmune encephalitis has not been studied separately. [4] Autoimmune encephalitis affects patients of all ages, mainly children, although the association with tumors, benign or malignant, may not be apparent at the first investigation. The other hallmark feature is that the neurological symptoms may relapse or progress if the disorder is not recognized in time.…”

Section: Introductionmentioning

confidence: 99%

Autoantibody-induced encephalitis

Singh

Paul

Bansal

et al. 2014

Int J Nutr Pharmacol Neurol Dis

View full text Add to dashboard Cite

Neurologists often encounter encephalitis caused by unknown agents. Autoantibody-induced encephalitis is a new and exciting group of disorders that must be considered in the differential diagnosis as they are reversible if treated early in the course of the disease, but fatal if unrecognized. We describe the first report from the Indian subcontinent of three rare cases of different autoantibody-induced disorders, which were successfully managed with immunosuppressive therapy resulting in a good clinical outcome. Case 1 was a young woman with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, not associated with tumor, who showed significant improvement with Rituximab. NMDA receptor encephalitis occurs typically in young females with psychiatric features, followed by an altered level of consciousness, dysautonomia, hyperkinetic movement disorder, seizures, and hypoventilation. Rituximab, which aims to suppress antibody production is an effective treatment modality. Anti-voltage-gated potassium channel antibodies (anti-VGKC-Ab) cause hyperexcitability of the peripheral nerve and central nervous system. Case 2 was a patient of limbic encephalitis presenting with complex partial seizures responding dramatically to steroids. Anti-VGKC-Ab-associated limbic encephalopathy is considered to be an autoimmune, non-paraneoplastic, potentially treatable encephalitis. The clinical features of anti-VGKC-Ab-associated limbic encephalitis are: Subacute onset of episodic memory impairment, disorientation, and agitation. Case 3 presented with Morvan's fibrillary chorea. Peripheral nerve hyperexcitability is the chief manifestation of the Morvan syndrome or cramp-fascilulation syndrome. The Morvan syndrome is characterized by neuromyotonia with autonomic and central nervous syndrome (CNS) involvement. Both VGKC-Ab-associated limbic encephalitis and Morvan syndrome can be successfully treated. Therefore, when these diseases are suspected, it is important to measure the anti-VGKC-Ab level.

show abstract

Laboratory evaluation of cases of meningitis attending a tertiary care hospital in India: An observational study

Cited by 6 publications

References 1 publication

Bacteriological Profile of Patients With Acute Pyogenic Meningitis - A Hospital Based Study

Bacteriological Profile of Patients With Acute Pyogenic Meningitis - A Hospital Based Study

Burden of central nervous system infection in cases of fever with seizure and its association with outcome: an experience in a tertiary care center of Uttarakhand, India

Autoantibody-induced encephalitis

Contact Info

Product

Resources

About