Laboratory Infection with Leishmania Donovani: A Case Report 1,2,3

Terry, Luther L.; Lewis, J. L.; Sessoms, Stuart M.

doi:10.4269/ajtmh.1950.s1-30.643

Cited by 22 publications

(8 citation statements)

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“…2,11,12,23 These animals present a certain degree of risk to humans, especially children, as the disease can be spread by direct contact. 12,21,22 The human risk is enhanced by the fact that infected dogs can remain clinically normal for extended periods of time.…”

Section: Canine Leishmaniasis Was Discovered By Nicolle and Compte Inmentioning

confidence: 99%

Canine Leishmaniasis Caused by Leishmania Leishmania Infantum in Two Labrador Retrievers

et al. 1992

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Abstract. Canine leishmaniasis, a generally fatal parasitic disease, was diagnosed in 2 dogs with a medical history of foreign travel, lymphadenopathy, emaciation, anorexia, intermittent fever, and cutaneous lesions.Clinically, hyperproteinemia, proteinuria, azotemia, and glomerulopathy were evident. Isolation of Leishmania species was done using Schneider's Drosophila medium. Syrian hamsters were used for infectivity studies. Clear taxonomic identification was done biochemically by isoenzyme analysis and comparison of zymogram banding patterns with 6 World Health Organization reference strains. Based on the geographic origin of affected dogs, clinicopathologic presentation, visceralization with hepatosplenomegaly in hamsters, and isoenzyme analysis, a diagnosis of Leishmania leishmania infantum was made. This study, representing the first taxonomic identification of an isolate from canine leishmaniasis, demonstrates the Zoonotic and epidemiologic implications of this disease.

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Section: Canine Leishmaniasis Was Discovered By Nicolle and Compte Inmentioning

confidence: 99%

Canine Leishmaniasis Caused by Leishmania Leishmania Infantum in Two Labrador Retrievers

et al. 1992

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“…The first laboratory infection probably occurred in China in 1930. The first proven laboratory infection with L. donovani was reported in 1950 [41]. Altogether, 12 laboratory transmissions with Leishmania have been published, out of which 6 occurred in the USA, 3 in Latin America, and 1 each in Asia, Canada and Europe [42].…”

Section: A 35 Transmissibilitymentioning

confidence: 99%

Arboprotozoae

2009

Transfus Med Hemother

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“…A technician working with laboratory animals infected with L. donovani developed a swollen finger and epitrochlear and axillary lymphadenopathy (162). His fingers had been bitten several times "within the few months" before the clinical manifestations first developed.…”

Section: Blood and Tissue Protozoamentioning

confidence: 99%

“…(a) Summary data. Twelve cases of laboratory-acquired leishmaniasis caused by six differ- (38,60,66,162), an organism that typically causes visceral leishmaniasis in infected humans but can cause cutaneous leishmaniasis, only one (38) developed clinical manifestations indicative of visceral involvement (e.g., fever, splenomegaly, and leukopenia). His case, which occurred in China in 1930, was the first documented case of laboratory-acquired leishmaniasis, although the remote possibility of vector-borne transmission could not be excluded.…”

Section: Blood and Tissue Protozoamentioning

confidence: 99%

Laboratory-Acquired Parasitic Infections from Accidental Exposures

2001

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SUMMARY Parasitic diseases are receiving increasing attention in developed countries in part because of their importance in travelers, immigrants, and immunocompromised persons. The main purpose of this review is to educate laboratorians, the primary readership, and health care workers, the secondary readership, about the potential hazards of handling specimens that contain viable parasites and about the diseases that can result. This is accomplished partly through discussion of the occupationally acquired cases of parasitic infections that have been reported, focusing for each case on the type of accident that resulted in infection, the length of the incubation period, the clinical manifestations that developed, and the means by which infection was detected. The article focuses on the cases of infection with the protozoa that cause leishmaniasis, malaria, toxoplasmosis, Chagas' disease (American trypanosomiasis), and African trypanosomiasis. Data about 164 such cases are discussed, as are data about cases caused by intestinal protozoa and by helminths. Of the 105 case-patients infected with blood and tissue protozoa who either recalled an accident or for whom the likely route of transmission could be presumed, 47 (44.8%) had percutaneous exposure via a contaminated needle or other sharp object. Some accidents were directly linked to poor laboratory practices (e.g., recapping a needle or working barehanded). To decrease the likelihood of accidental exposures, persons who could be exposed to pathogenic parasites must be thoroughly instructed in safety precautions before they begin to work and through ongoing training programs. Protocols should be provided for handling specimens that could contain viable organisms, using protective clothing and equipment, dealing with spills of infectious organisms, and responding to accidents. Special care should be exercised when using needles and other sharp objects.

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Laboratory Infection with Leishmania Donovani: A Case Report 1,2,3

Cited by 22 publications

References 0 publications

Canine Leishmaniasis Caused by Leishmania Leishmania Infantum in Two Labrador Retrievers

Canine Leishmaniasis Caused by Leishmania Leishmania Infantum in Two Labrador Retrievers

Arboprotozoae

Laboratory-Acquired Parasitic Infections from Accidental Exposures

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