Laboratory investigation of platelets

Stability of hematologic analytes in monkey, rabbit, rat, and mouse blood stored at 4°C in EDTA using the ADVIA 120 hematology analyzer

“…Increased MPV was probably due to an enlargement of platelets in stored samples. Because MPV is commonly used as an indicator of platelet activation and thrombopoiesis, 21 artificial platelet swelling complicates the interpretation of MPV findings. The results of this study indicate that MPV should be measured within 1 hour of blood sampling for monkeys and mice and by 24 hours after collection in rabbits.…”

Effects of resveratrol and other wine polyphenols on vascular function: an update

“…Therefore, the effects of wine intake on ex vivo platelet function in healthy humans are still controversial. Likely, part of the discrepancies derive from the different sensitivity of the techniques adopted to study platelet function in the different studies and from their inherent variability [57]. Most conceivably, a more clear inhibitory effect of wine intake may be observed in patients with cardiovascular disease and/or risk factors, in whom a platelet hyperreactivity is present, than in healthy volunteers.…”

Assessment of Platelet Function on Whole Blood by Multiple Electrode Aggregometry in High-Risk Patients With Coronary Artery Disease Receiving Antiplatelet Therapy

“…[6][7][8] Light transmission aggregometry (LTA) in platelet-rich plasma (PRP) 9 is considered a standard method for assessing platelet reactivity to different agonists such as arachidonic acid (AA) and adenosine-5 diphosphate (ADP) after administration of aspirin and clopidogrel, respectively. [10][11][12][13] However, LTA is a manual and time-consuming method and requires dedicated laboratories. So, a simple and rapid method to evaluate platelet function in treated patients might be useful in clinical practice.…”