Laboratory parameters and outcomes in hospitalized adults with COVID-19: a scoping review

Abstract

Background Laboratory parameters and the associated clinical outcomes have been an area of focus in COVID-19 research globally. Purpose We performed a scoping review to synthesize laboratory values described in the literature and their associations with mortality and disease severity. Methods We identified all primary studies involving laboratory values with clinical outcomes as a primary endpoint by performing data searches in various systematic review databases until 10th August, 2020. Two reviewers independently reviewed all abstracts (13,568 articles) and full text (1126 articles) data. A total of 529 studies involving 165,020 patients from 28 different countries were included. Investigation of the number of studies and patients from a geographical perspective showed that the majority of published literature from January-March 2020 to April-June 2020 was from Asia, though there was a temporal shift in published studies to Europe and the Americas. For each laboratory value, the proportion of studies that noted a statistically significant (p < 0.05) correlation with adverse clinical outcomes (e.g., mortality, disease severity) was tabulated. Results and conclusion Among frequently reported laboratory values, blood urea nitrogen was the most often reported predictor of mortality (91%); neutrophil-to-lymphocyte ratio was the most frequent statistically significant laboratory parameter in predicting disease severity (96%). This review highlights the temporal progression of laboratory value frequencies, as well as potentially distinct utilities of different markers for clinical outcomes of COVID-19. Future research pathways include using this collected data for focused quantitative meta-analyses of particular laboratory values correlated with clinical outcomes of mortality and disease severity.

Biochemical and hematological factors associated with COVID-19 severity among Gabonese patients: A retrospective cohort study

“…However, similar results were found in China (Chen et al, 2020;Chen et al, 2021). High levels of urea predict mortality in UK and other countries (Aloisio et al, 2020;Zhu et al, 2022;Burke et al, 2022). Liver enzymes increase gradually with COVID-19 severity (Guan et al, 2020;Chen et al, 2021) and are high in approximately 25% of patients (Wijarnpreecha et al, 2021).…”

“…In Africa, few data on biological characteristics of COVID-19 patients are available. In their meta-analysis of 13,568 articles, Zhu Andrew et al (Zhu et al, 2022) found that most data came from Asia, followed by Europe, then North and South America. No data from Africa were mentioned in that study.…”

Características del SARS-CoV-2, COVID-19 y su diagnóstico en el laboratorio

“…Aunque las pruebas de laboratorio de rutina son poco específicas para la infección por SARS-CoV-2, pueden orientar hacia la determinación de la severidad de la enfermedad y su pronóstico, además de facilitar el seguimiento del paciente [42,43]. Las alteraciones encontradas en pacientes infectados son principalmente cambios en el hemograma (linfopenia), aumento de los valores de las enzimas hepáticas, la creatinina y la urea, y de los marcadores inespecíficos de inflamación y lesión, como la proteína C reactiva (PCR), la enzima lactato deshidrogenasa (LDH), el dímero D y la ferritina [43].…”

CT score in COVID-19-related pneumonia, the radiologist, and the internist. Trying to unmask who is “the good”, who is “the bad” and who is “the ugly”

“…Moreover, it is quite surprising that in the present study a limited number of comorbidities were reported in the study population considering that COVID-19 patients usually present a high rate of comorbidities which in turn have a remarkable impact on clinical outcomes [ 3 ]. Finally, there was no relationship between CT severity score and crucial laboratory parameters recurrently used during COVID-19 pandemic such as transferrin, lactate dehydrogenase, troponin, and inflammation related factors of leucocytes, neutrophils, and IL-2R [ 10 ].…”