Laboratory Profiles in Cats with Different Pathological and Immunohistochemical Findings Due to Feline Infectious Peritonitis (FIP)

Paltrinieri, Saverio; Grieco, Valeria; Comazzi, S.; Parodi, M. Cammarata

doi:10.1053/jfms.2001.0126

Cited by 44 publications

(42 citation statements)

References 20 publications

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“…Our findings confirm the heterogeneous nature of FIP lesions, previously described by others (Kipar et al, 1998;Paltrinieri et al, 2001). Indeed, the results of the present study suggest that the commonly used subdivision of the disease into ''wet'' and ''dry'' forms is based more on clinical presentation than on any morphological criteria.…”

Section: Discussionsupporting

confidence: 92%

Cellular composition and interferon-γ expression of the local inflammatory response in feline infectious peritonitis (FIP)

Berg

Ekman

Belák

et al. 2005

Veterinary Microbiology

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Feline infectious peritonitis (FIP) is one of the most important viral diseases of cats. International studies estimate that approximately 80% of all purebred cats are infected with the causative agent, feline coronavirus (FCoV). Out of these, 5-12% develop clinical symptoms of FIP. The pathogenesis of the disease is complex with many unresolved issues relating to the role of the immune system. The aim of the present study was to determine the proportions of various inflammatory cell types in FIP lesions by using a panel of cat specific, thoroughly validated, monoclonal antibodies. In addition, the expression of interferon-gamma within the inflammatory lesions was examined by RT-PCR. Our results confirm the mixed nature of the inflammatory reaction in FIP, involving B cells and plasma cells as well as CD4+ and CD8+ T cells. However, one cell type stands out as being the key element in both the "wet" and "dry" forms of FIP: the macrophage. Upregulation of IFN-gamma expression within the inflammatory lesions suggests a local activation of macrophages, which might result in increased viral replication.

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Section: Discussionsupporting

confidence: 92%

Cellular composition and interferon-γ expression of the local inflammatory response in feline infectious peritonitis (FIP)

Berg

Ekman

Belák

et al. 2005

Veterinary Microbiology

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“…PCV was recorded if HCT was not available (usually in cats presented out of hours). Anaemia severity was classified, based on HCT or PCV, as mild (20)(21)(22)(23)(24).9%), moderate (14)(15)(16)(17)(18)(19).9%), severe (11-13.9%) or very severe (<10.9%). Aggregate reticulocyte counts, when performed, were used to classify the anaemia as non-regenerative (<0.015 × 10 12 /l), weakly regenerative (0.016-0.05 × 10 12 /l), moderately regenerative (0.06-0.19 × 10 12 /l) or strongly regenerative (>0.2 × 10 12 /l).…”

Section: Data Recordingmentioning

confidence: 99%

A retrospective study of 180 anaemic cats: features, aetiologies and survival data

Korman

Hetzel

Knowles

et al. 2012

Journal of Feline Medicine and Surgery

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The study comprised 180 anaemic cats. Descriptive and survival data were obtained. Cats were classified by aetiology of anaemia development and degenerative, anomalous, metabolic, miscellaneous, neoplastic, infectious, inflammatory, immune-mediated, toxic, traumatic or vascular disease (DAMNITV) classification and anaemia severity. Sixty-four (35.6%) cats had mild [packed cell volume (PCV)/haematocrit (HCT) 20-24.9%], 58 (32.2%) moderate (14-19.9%), 23 (12.8%) severe (11-13.9%) and 35 (19.4%) very severe (<10.9%) anaemia. By aetiology of anaemia development, bone marrow (BM) abnormalities were more common (95, 52.8%) than haemorrhage (37, 20.6%) or haemolysis (19, 10.6%). By DAMNITV classification, infectious diseases were more common (39, 21.7%) than neoplasia (36, 20%), metabolic (21, 11.7%), trauma (15, 8.3%), miscellaneous (14, 7.8%), inflammatory (11, 6.1%), immune-mediated (11, 6.1%), anomalous (8, 4.4%), toxic (2, 1.1%) or vascular disease (1, 0.6%). BM abnormalities were significantly associated with more severe anaemia (P = 0.003). Most cats (112, 62.2%) survived to discharge whereas 55 (30.6%) were euthanased and 13 (7.2%) died. Survival to discharge was not associated with anaemia severity but was associated significantly with aetiology of anaemia development (P = 0.046), as cats with haemolysis were more likely to survive to discharge than cats with BM abnormalities. Survival to discharge was also associated significantly with DAMNITV classification (P = 0.010), with cats with neoplasia being less likely, and cats with immune-mediated disease more likely, to survive to discharge. Cox regression analysis found that survival was not associated with anaemia severity, but was associated with DAMNITV classification (P = 0.011) and age (P = 0.082), with cats with immune-mediated disease and younger cats more likely to survive.

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“…Blood cell counts are often changed in cats with FIP [102,103]; however, changes are not pathognomonic. White blood cells can be decreased or increased.…”

Section: Complete Blood Cell Counts and Coagulation Parametersmentioning

confidence: 99%

Feline infectious peritonitis

Hartmann

2005

Veterinary Clinics of North America: Small Animal Practice

148

251

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The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this disease in the last years, there are still many unanswered questions. The objective of this article is to review recent knowledge and to increase understanding of the complex pathogenesis of FIP.

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Laboratory Profiles in Cats with Different Pathological and Immunohistochemical Findings Due to Feline Infectious Peritonitis (FIP)

Cited by 44 publications

References 20 publications

Cellular composition and interferon-γ expression of the local inflammatory response in feline infectious peritonitis (FIP)

Cellular composition and interferon-γ expression of the local inflammatory response in feline infectious peritonitis (FIP)

A retrospective study of 180 anaemic cats: features, aetiologies and survival data

Feline infectious peritonitis

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