The degradation of acetaminophen (APAP) in aqueous solutions with heterogeneous Fenton reactions was investigated with montmorillonite KSF as catalyst. The influencing factors of the initial APAP concentration, initial pH value, initial KSF dosage and H 2 O 2 dosage were studied. The results showed that APAP could be effectively degraded under the conditions of pH 4.0, KSF 0.2 g/L and H 2 O 2 0.5 mM, and the degradation efficiency of 0.5 mg/L APAP reached 93.5% after reaction for 30 min. The degradation kinetics of APAP followed the pseudo first-order rate law.