Laboratory Tests, Noninvasive Markers of Fibrosis, Liver Biopsy, and Laparoscopy

Curry, Michael P.; Jeffers, Lennox J.

doi:10.1002/9781119251316.ch2

Cited by 5 publications

(6 citation statements)

References 74 publications

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“…The pathologist was blinded to the imaging findings. Fibrosis stages were described based on the METAVIR score[23] as follows: F0, no fibrosis; F1, portal fibrosis without septa; F2, few septa; F3, numerous septa without cirrhosis; and F4, cirrhosis.…”

Section: Methodsmentioning

confidence: 99%

The clinical value of the apparent diffusion coefficient of liver magnetic resonance images in patients with liver fibrosis compared to healthy subjects

Shayesteh

Motamedfar

et al. 2018

J Family Med Prim Care

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Background:Fibrotic tissue forms following chronic inflammation in the liver, which may progress over time to cirrhosis. Liver biopsy is the gold standard for the diagnosis of liver fibrosis, and there has been a considerable interest in developing noninvasive methods.Objectives:In the present study, we evaluated the efficacy of the apparent diffusion coefficient (ADC) of the liver in the diagnosis and staging of liver fibrosis.Patients and Methods:This case–control study was conducted on 40 patients with chronic liver disease and 31 healthy controls who were subjected to diffusion-weighted magnetic resonance imaging (MRI). Diagnostic values for different stages of fibrosis were determined using receiver-operating characteristic (ROC) curves based on the sensitivity and specificity.Results:Of 37 patients in the case group, 12 were males (32.4%) and 25 (67.5%) were females, whereas in the control group of 31 patients, 11 were males (35.5%) and 20 (64.5%) were females. In the ROC analysis, area under the curve separating stage one or lower fibrosis from stage two or greater fibrosis groups with a b-value of 600 s/mm2 was 0.893 (98% confidence interval (CI): 0.795–0.955), and that with a b-value of 1000 s/mm2 was 0.946 (98% CI: 0.813–0.946).Conclusion:Our results are in line with the previous studies, which showed that liver ADC values could be considered as a method for the diagnosis and staging of liver fibrosis.

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Section: Methodsmentioning

confidence: 99%

The clinical value of the apparent diffusion coefficient of liver magnetic resonance images in patients with liver fibrosis compared to healthy subjects

Shayesteh

Motamedfar

et al. 2018

J Family Med Prim Care

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“…Coagulopathy patients included non-overt DIC patients and overt DIC patients. Acute liver injury was identified according to Schiff's diseases of the liver (Curry and Jeffers, 2017[ 6 ]) that the level of alanine aminotransferase exceeds twice the upper limits of normal (ALT > 80 U/L) (Curry and Jeffers, 2017[ 6 ]). Abnormal renal function was defined as serum levels of kidney creatinine were above upper limit of normal value (133 μmol/L).…”

Section: Methodsmentioning

confidence: 99%

Coagulopathy is associated with multiple organ damage and prognosis of COVID-19

Zhang

Liu

Zhang

et al. 2021

EXCLI Journal; 20:Doc174; ISSN 1611-2156

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“…For high INR, >1.4, due to cholestasis, administration of ageadjusted parenteral injection of vitamin K was performed before contemplating liver biopsy. 19 After being satisfied about the adequacy of the size of the tissue biopsy sample, a histology report confirming cirrhosis needed to be established by a team of two pathologists, both at the level of consultant, who were not aware of the patient's clinical data.…”

Section: Methodsmentioning

confidence: 99%

<p>Validation of Revised Baveno VI Criteria for Screening of Varices Needing Treatment in Children with Cirrhosis</p>

Samanta¹,

Biswas²,

Ghosh³

et al. 2020

CEG

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Background: Baveno VI criteria for screening varices needing treatment (VNT) have not yet been validated in an exclusive pediatric and adolescent set of the population, in whom baseline parameters differ in relation to adults. Therefore, our primary objective was to validate Baveno VI and its expanded form in children below 18 years of age. The secondary aim was to elicit whether any revision of the above criteria with a target of not missing more than 5% VNT could be more accurate for this age group. Materials and Methods: The work was carried out in two medical institutes, over a span of 3 years. Consecutively enrolled patients below 18 years of age, with compensated cirrhosis confirmed by liver biopsy, were evaluated for related blood parameters, transient elastography (TE) and esophagogastroduodenoscopy. Results: Out of the 33 recruited patients, five (15.15%) met the criteria for VNT. The sensitivity, specificity, PPV and NPV of Baveno VI and Expanded Baveno VI were observed as 60%, 92.3%, 60% and 92.3%, and 20%, 100%, 100% and 88%, respectively. We found that the Revised Baveno VI criteria with TE <19 kPa and platelet count of >175×10 9 cells/L, with sensitivity 100%, specificity 79%, PPV 45%, NPV 100% and accuracy of 82%, are more appropriate for this age group. Conclusion: We propose that further multicentrer studies with a larger sample size should be conducted before incorporating Revised Baveno VI criteria for high-risk varices in patients below 18 years in future guidelines.

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Laboratory Tests, Noninvasive Markers of Fibrosis, Liver Biopsy, and Laparoscopy

Cited by 5 publications

References 74 publications

The clinical value of the apparent diffusion coefficient of liver magnetic resonance images in patients with liver fibrosis compared to healthy subjects

The clinical value of the apparent diffusion coefficient of liver magnetic resonance images in patients with liver fibrosis compared to healthy subjects

Coagulopathy is associated with multiple organ damage and prognosis of COVID-19

<p>Validation of Revised Baveno VI Criteria for Screening of Varices Needing Treatment in Children with Cirrhosis</p>

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