Lacidipine blunts early vascular activation in dyslipidemic hypertensives.

Ferri, Claudio; Desideri, Giovambattista; Giuliani, E.; Gentile, Marco; Pazienza, Michelle; Pasin, Mauro; Baldoncini, R.; Bellini, Cesare; Santucci, A.

doi:10.1016/s0895-7061(99)80648-7

American Journal of Hypertension

1999

DOI: 10.1016/s0895-7061(99)80648-7

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Lacidipine blunts early vascular activation in dyslipidemic hypertensives.

Claudio Ferri

Giovambattista Desideri

E. Giuliani

et al.

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“…A dose of 2-8 mg of lacidipine a day can lower blood pressure for 24 h (Zanchetti et al, 2007). In addition to reduce blood pressure, lacidipine also possesses antiatherosclerosis (Yetik-Anacak et al, 2010) by protecting endothelial function (Ferri et al, 1999), inhibiting adhesion molecules expression (Park et al, 2002), adjusting matrix metalloproteinases (Bellosta et al, 2001) and beneficial effect on bone metabolism (Halici et al, 2008).…”

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Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues

et al. 2011

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Six analogues of lacidipine, (E)-diethyl 4-(2-(3-amino)-3-oxoprop-1-enyl)phenyl-2, 6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates (compounds 1-6), were synthesized and their antihypertensive effects in spontaneously hypertensive rats were evaluated by ig administration. Amongst the tested compounds, compound 5 exhibited the highest antihypertensive effect. The lasting time and potency of compound 5 showed a dose-dependent manner. The results suggested that N-tert-butyl acrylamide moiety at 2 0 -position of 4-phenyl in the structure of analogues of lacidipine is necessary to keep antihypertensive effects.

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Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues

et al. 2011

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Lacidipine

McCormack¹,

Wagstaff²

2003

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Lacidipine is an effective, well tolerated, once-daily, oral antihypertensive agent that can be used in a wide variety of patients. As with other members of its class, lacidipine has shown potentially beneficial antiatherosclerotic effects, although definitive data with respect to possible superiority over other drug classes are still required. Therefore, lacidipine is an attractive therapy for the long-term management of essential hypertension.

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Lacidipine blunts early vascular activation in dyslipidemic hypertensives.

Cited by 2 publications

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Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues

Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of lacidipine analogues

Lacidipine

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