Lack of 5-HT1B receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus

Upton, Amy L.; Ravary, Anne; Salichon, Nathalie; Moessner, Rainald; Lesch, Klaus‐Peter; R, Hen; Seif, Isabelle; Gaspar, Patricia

doi:10.1016/s0306-4522(01)00602-9

Cited by 52 publications

(57 citation statements)

References 36 publications

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“…Eye specific segregation of retinal projections in the thalamus depends also on appropriate 5-HT levels 23 . Indeed, eye-specific segregation fails to form in animals lacking monoamine oxidaseA or SERT, i.e.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Modulates Developmental Microglia via 5-HT_2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

Kołodziejczak

Béchade

Gervasi

et al. 2015

ACS Chem. Neurosci.

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Abstract.Maturation of functional neuronal circuits during central nervous system development relies on sophisticated mechanisms. First, axonal and dendritic growth should reach appropriate targets for correct synapse elaboration. Second, pruning and neuronal death are required to eliminate redundant or inappropriate neuronal connections. Serotonin, in addition to its role as a neurotransmitter, actively participates in postnatal establishment and refinement of brain wiring in mammals. Brain resident macrophages, i.e. microglia, also play an important role in developmentally-regulated neuronal death as well as in synaptic maturation and elimination. Here, we tested the hypothesis of cross-regulation between microglia and serotonin during postnatal brain development in a mouse model of synaptic refinement. We found expression of the serotonin 5-HT 2B receptor on postnatal microglia, suggesting that serotonin could participate in temporal and spatial synchronization of microglial functions. Using two-photon microscopy, acute brain slices and local delivery of serotonin, we observed that microglial processes moved rapidly toward the source of serotonin in Htr 2B +/+ mice, but not in Htr 2B-/-mice lacking the 5-HT 2B receptor. We then investigated whether some developmental steps known to be controlled by serotonin, could potentially result from microglia sensitivity to serotonin. Using an in vivo model of synaptic refinement during early brain development, we investigated the maturation of the retinal projections to the thalamus and observed that Htr 2B -/-mice present anatomical alterations of the ipsilateral projecting area of retinal axons into the thalamus. In addition, activation markers were upregulated in microglia from Htr 2B -/-compared to control neonates, in the absence of apparent morphological modifications. These results support the hypothesis that serotonin interacts with microglial cells and these interactions participate in brain maturation.

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Section: Discussionmentioning

confidence: 99%

Serotonin Modulates Developmental Microglia via 5-HT_2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

Kołodziejczak

Béchade

Gervasi

et al. 2015

ACS Chem. Neurosci.

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“…This disrupted pattern can be rescued by inhibiting 5-HT synthesis during the first 2 weeks of life (Upton et al, 1999). During this 2-week period, retinal fibers transiently express 5-HTT, VMAT2, and HTR1B (Hansson et al, 1998;Lebrand et al, 2006;Upton et al, 2002;Upton et al, 1999). Therefore, a similar mechanism is proposed for the 5-HT-mediated alteration in pattern development in somatosensory and visual systems.…”

Section: -Ht and Visual System Developmentmentioning

confidence: 94%

Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

Suri

Teixeira

Cagliostro

et al. 2014

Neuropsychopharmacol

144

125

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Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system development, such sensitive periods shape the formation of neurocircuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint as well as the environmental context. While allowing for adaptation, such sensitive periods are also vulnerability windows during which external and internal factors can confer risk to disorders by derailing otherwise resilient developmental programs. Here we review developmental periods that are sensitive to monoamine signaling and impact adult behaviors of relevance to psychiatry. Specifically, we review (1) a serotonin-sensitive period that impacts sensory system development, (2) a serotonin-sensitive period that impacts cognition, anxiety-and depressionrelated behaviors, and (3) a dopamine-and serotonin-sensitive period affecting aggression, impulsivity and behavioral response to psychostimulants. We discuss preclinical data to provide mechanistic insight, as well as epidemiological and clinical data to point out translational relevance. The field of translational developmental neuroscience has progressed exponentially providing solid conceptual advances and unprecedented mechanistic insight. With such knowledge at hand and important methodological innovation ongoing, the field is poised for breakthroughs elucidating the developmental origins of neuropsychiatric disorders, and thus understanding pathophysiology. Such knowledge of sensitive periods that determine the developmental trajectory of complex behaviors is a necessary step towards improving prevention and treatment approaches for neuropsychiatric disorders.

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“…These models provided clear evidence that 5-HT modulates activity-dependent refinement of neural circuits. MAOA KO and SERT-KO mice had altered development of the barrel cortex (Cases et al, 1996;Persico et al, 2001;Salichon et al, 2001) and refinement of the retinal projections in central targets (Upton et al, 1999(Upton et al, , 2002. Moreover, these models demonstrated that abnormal adult behavior could result from changes in serotonin levels during development.…”

Section: Introductionmentioning

confidence: 99%

Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?

Trowbridge¹,

Narboux-Nême²,

Gaspar³

2010

The Anatomical Record

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A large number of hyposerotonergic genetic models have been generated over the past few years. Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Here we review these various models from a developmental perspective, beginning with a description of the sources of 5-HT during development. We then summarize the neurological and behavioral alterations that have been observed in the genetic hyposerotonergic models. Although these models appear to have normal brain development and do not exhibit any gross morphological defects, problems in somatic growth and physiological functions have been observed. Abnormal adult behavior is also seen, although whether it results from depletion of 5-HT during development or functional 5-HT deficiencies in adult life remains unclear. Evidence from these hyposerotonergic models suggests that the developing brain may not need 5-HT for the establishment of general organization and structure. However, central 5-HT appears to be necessary for postnatal body growth, maturation of respiratory and vegetative control, and possibly for the development of normal adult behavior. Anat Rec, 294:1615Rec, 294: -1623Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Lack of 5-HT1B receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus

Cited by 52 publications

References 36 publications

Serotonin Modulates Developmental Microglia via 5-HT_2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

Serotonin Modulates Developmental Microglia via 5-HT_2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?

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Lack of 5-HT1B receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus

Cited by 52 publications

References 36 publications

Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?

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Product

Resources

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Serotonin Modulates Developmental Microglia via 5-HT_2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections

Serotonin Modulates Developmental Microglia via 5-HT_2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections