Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects

Abstract

BackgroundThe association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed.MethodsBased on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and abstracted outcome data from all articles to evaluate the association between CYP11B2 polymorphism and ischemic stroke. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed in all genetic models. Fixed or random effects model was separately used depending on the heterogeneity between studies. Publication bias was tested by Begg's funnel plot and Egger's regression test.ResultsA total of 12 studies including 3,620 ischemic stroke cases and 4,090 controls were identified. There was no statistical evidence of association between CYP11B2 C-344T polymorphism and ischemic stroke in all genetic models (allelic model: OR = 1.19, 95% CI = 0.95–1.49; additive model: OR = 1.43, 95% CI = 0.91–2.27; dominant model: OR = 1.30, 95% CI = 0.89–1.89; and recessive model: OR = 1.24, 95% CI = 0.96–1.60). On subgroup analysis by ethnicity, similarly results were found in both Asians and non-Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.07, 95% CI = 0.87–1.32; additive model: OR = 1.15, 95% CI = 0.77–1.71; dominant model: OR = 1.13, 95% CI = 0.92–1.38; and recessive model: OR = 1.09, 95% CI = 0.84–1.40). For none-Asians, the combined ORs and 95% CIs were (allelic model: OR = 1.58, 95% CI = 0.90–2.76; additive model: OR = 2.37, 95% CI = 0.79–7.05; dominant model: OR = 1.79, 95% CI = 0.77–4.19; and recessive model: OR = 1.80, 95% CI = 0.96–3.36).ConclusionThe present meta-analysis suggested that CYP11B2 C-344T polymorphism was unlikely contribute to ischemic stroke susceptibility.

No Association Between SNP56 in PDE4D Gene and Susceptibility to Ischemic Stroke: A Meta-Analysis of 15 Studies

“…Variants in several genes were identified as risk factors for IS, including apolipoprotein B , beta-2 adrenergic receptor , methylenetetrahydrofolate reductase ( MTHFR), and HDAC9 [49–53]. However, some other variants, such as IL-6 G572C, PON1 L55M, and CYP11B2 C-344T were not associated with susceptibility to IS [44,54,55]. Thus, we saw the need to perform a meta-analysis aimed to investigate the contribution of SNP56 in the PDE4D gene to IS.…”

Clinical Pharmacogenetics of Angiotensin II Receptor Blockers in Iraq

“…[ 47 ] In contrast, Pi et al . [ 48 ] conducted a meta-analysis in 2013 to investigate genetic susceptibility to ischemic stroke using the 344C/T polymorphism of the CYP11B2 gene, and their results did not find any relationship between the two. [ 48 ]…”

“…concluded that the homogeneous T allele of the –344C/T polymorphism of the CYP11B2 gene was a marker of the risk of developing hypertension but was not associated with vascular changes in hypertension. [ 43 , 48 ]…”

Polymorphisms of Some Genes, Associated With Hypertension: A Review of Relevant Publications

“…However, there have been some studies, the results of which did not reveal the association of CYP11B2 gene polymorphisms with the development of cardiovascular diseases [33][34][35][36][37].…”