Lack of any Association between Insertion/Deletion (I/D) Polymorphisms in the Angiotensin-converting Enzyme Gene and Digestive System Cancer Risk: a Meta-analysis

Liu, Jinfei; Xie, Haojun; Cheng, Tina

doi:10.7314/apjcp.2013.14.12.7271

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…Our results did not show any association between ACE I/D polymorphism and CRC in each genetic models ( P > 0.05). This is in accordance with meta-analysis conducted by Liu et al and Zhang et al [12,45]. …”

Section: Discussionsupporting

confidence: 93%

Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis

Zhou

Lin

2015

World J Surg Onc

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BackgroundColorectal cancer (CRC) is the most common cause of cancer death worldwide. Numerous studies have identified the roles of survivin −31 G/C and angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms in CRC risk; however, the results remain inconclusive. This study was to investigate associations between these two polymorphisms and CRC susceptibility.MethodsA comprehensive literature search was conducted to collect relevant case–control studies published between 2000 and 2014. The extracted data were statistically analyzed, and the odds ratios (ORs) with 95% confidence intervals (CIs) were employed to estimate the strength of association.ResultsA total of 11 studies were included in the meta-analysis. For survivin G/C polymorphism, six articles reported 1,840 cases and 1,804 controls. Overall, we found the frequency of C allele is higher in CRC cases than that in the healthy controls (57.2% vs. 48.0%), and C allele significantly increased the risk of CRC compared to G allele in allele model (OR = 1.46, 95% CI = 1.33–1.60, P < 0.00001). This association was also found in other genetic models (P < 0.00001). Stratified analysis by ethnicity showed significant association in each genetic model among the Asian population. For ACE I/D polymorphism, five studies included 758 cases and 6,755 controls. No significant association was found in any genetic models.ConclusionsOur results showed that survivin −31 G/C polymorphism might contribute to risk of CRC, especially in the Asian populations. However, the ACE I/D polymorphism is not a genetic factor concerning the risk for CRC. More studies with larger sample sizes are required in the future.

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Section: Discussionsupporting

confidence: 93%

Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis

Zhou

Lin

2015

World J Surg Onc

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“…When differential expression of microRNAs was detected in plasma of patients with laryngeal squamous cell carcinoma, hsa-miR-19a-3p was confirmed as a potential early-detection marker for laryngeal squamous cell carcinoma (Ayaz et al 2013). Also, hsa-miR-19a-3p was texted in breast cancer grouped by clinicopathological subtypes (Liu et al 2013). Down-regulation of miR-181b promoted apoptosis by targeting CYLD in thyroid papillary cancer, and hsa-miR-19a-3p was detected and played an important role (Li et al 2014).…”

Section: Discussionmentioning

confidence: 90%

Integrated bioinformatics analysis of miRNA expression in osteosarcoma

Wang

Xie

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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The expression of miRNA influencing the pathogenesis of OS have been reported previously, however, different samples selection and sequencing platforms made obvious differences in miRNA expression analysis. We aim to identify reliable prognostic and treatment biomarkers for OS by systematic analysis of miRNAs expression data sets from biased data set. Seven miRNA data sets were selected from corresponding articles. Collectively, two miRNAs, hsa-miR-19-3p and hsa-miR106b-3p, and transcription factor SIX3 were identified and may be reliable markers for prognostic and treatment of osteosarcoma.

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“…Considering the multifactorial and heterogeneous nature of cancer, there is a necessity to establish a catalogue of driver genes or loci for each tumor type. As an extension of a recent meta-analysis by Liu et al, 31 we identified the source of the controls as a potential contributor to account for strong evidence of heterogeneity in this meta-analysis. Ruano-Ravina and colleagues have done a methodological comparison between populationbased and hospital-based controls on lung cancer risk, and highlighted obvious differences between the two sources of controls in risk estimates.…”

Section: Discussionmentioning

confidence: 97%

The relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive cancer risk: Insights from a meta-analysis

Yang

Cai

et al. 2015

J Renin Angiotensin Aldosterone Syst

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Background and objective: The gene encoding angiotensin-converting enzyme (ACE) has been implicated in the development of several malignancies. We aimed to meta-analyze the association of ACE gene insertion/deletion (I/D) polymorphism with digestive cancer risk and seek possible sources of between-study heterogeneity. Methods: Two authors independently assessed eligibility of each retrieved publication and gathered relevant data. Risk estimates were expressed as odds ratio (OR) and 95% confidence interval (CI). Results: Sixteen publications were qualified for analysis, involving 2903 digestive cancer cases and 10,833 controls. Overall analyses failed to show any significance for digestive cancer risk. There was moderate heterogeneity and lower publication bias for overall comparisons. In subgroup analyses, ACE gene II genotype was associated with a 15% reduced risk (OR=0.85, 95% CI: 0.57–1.27, p=0.434) for gastric cancer, but a 16% increased risk (OR=1.16, 95% CI: 0.89–1.52, p=0.273) for colorectal cancer. By source of controls, the I allele appeared to be a protective factor against digestive cancer in population-based studies (OR=0.87, 95% CI: 0.75–1.00, p=0.055) but a risk-conferring factor in hospital-based studies (OR=1.17, 95% CI: 1.01–1.35, p=0.033). Conclusion: Our findings suggested that ACE gene I allele might be a protective factor against gastric cancer, necessitating further confirmation in large, population-based studies.

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Lack of any Association between Insertion/Deletion (I/D) Polymorphisms in the Angiotensin-converting Enzyme Gene and Digestive System Cancer Risk: a Meta-analysis

Cited by 7 publications

References 19 publications

Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis

Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis

Integrated bioinformatics analysis of miRNA expression in osteosarcoma

The relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive cancer risk: Insights from a meta-analysis

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