Lack of association between angiotensin-converting enzyme (ACE) genotype and essential hypertension in Peruvian older people

Oscanoa, Teodoro J.; Cieza, Edwin; Caparó, Frank Lizaraso; Guevara, María L.; Fujita, Ricardo; Romero-Ortuño, Román

doi:10.5603/ah.a2020.0011

Cited by 3 publications

(4 citation statements)

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“…In the current study, this role for the D allele was not confirmed and no significant differences were found in the distribution of allele or genotype frequencies of rs4646994 polymorphism between diabetic and non-diabetic or hypertensive and non-hypertensive COVID-19 patients. Consistent with our observation, the rs4646994 polymorphism was also not associated with hypertension in African-Brazilians, Caucasians-Brazilians and Peruvians ( Bonfim-Silva et al, 2016 ; Oscanoa et al, 2020 ). Similarly, this polymorphism was not associated with diabetes in Brazilians and Chinese ( Bonini Domingos et al, 2014 ; Zhou et al, 2012 ).…”

Section: Discussionsupporting

confidence: 92%

Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients

et al. 2022

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Susceptibility to coronavirus disease 2019 (COVID-19) and disease severity has recently been associated with inflammatory markers and genetic polymorphisms of ACE (angiotensin-converting enzyme) and ACE2 genes, but the evidence has been inconclusive. This case-control study (99 COVID-19 patients and 96 controls) sought to assess the significance of age, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and SARS-CoV-2 RT-PCR cycle threshold (Ct) in severity of COVID-19. Besides, two variants of ACE and ACE2 genes (rs4646994 and rs2285666, respectively) were analyzed to determine their role in COVID-19 susceptibility and/or disease severity. Results revealed that age, CRP and NLR were significantly elevated in severe cases compared to moderate cases, while RT-PCR Ct value was significantly decreased. Allele and genotypes of both variants were not associated with COVID-19 risk, with the exception of rs2285666 A allele. It showed a significantly higher frequency in female patients than in female controls (probability = 0.041 ) . In conclusion, the study indicated the role of age, CRP, NLR and SARS-CoV-2 RT-PCR Ct in susceptibility to COVID-19 severity. However, analysis of the ACE and ACE2 gene variants (rs4646994 and rs2285666, respectively) showed that the two variants were not associated with the risk of developing COVID-19.

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Section: Discussionsupporting

confidence: 92%

Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients

et al. 2022

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“…Studies conducted in populations from Pakistan (42) and Brazil (44) showed that ACE-DD was associated with a high incidence of HTN. Contradictory results were found from a study conducted in Afro-Brazilian and Caucasian populations (45) and the Peruvian elderly population (43), which showed no association between the ACE gene I/D polymorphism and HTN. Therefore, the controversial results about the association of ACE with hypertension and other cerebrovascular diseases in different populations may be due to interactions between genetic and some environmental factors that explain the complexity of genetic architecture (46).…”

Section: Discussionmentioning

confidence: 93%

“…In addition to the association between ACE polymorphism and IS, the contribution of other risk factors, such as the relation between ACE gene I/D polymorphism and patients with HTN without known histories of stroke, was studied in different populations ( 42 ). However, there are conflicting results regarding ACE polymorphisms and HTN risk ( 43 ). Studies conducted in populations from Pakistan ( 42 ) and Brazil ( 44 ) showed that ACE-DD was associated with a high incidence of HTN.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of ischemic stroke complication among patients with hypertension in the Ethiopian population

Melake

Brhanie

2023

Front. Neurol.

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BackgroundIschemic stroke is a complicated, multifaceted condition brought on by a confluence of vascular, environmental, and genetic variables. The burden of ischemic stroke is currently rising in terms of death, morbidity, and disability worldwide. Genetic variables also play significant roles in the pathophysiology of hypertension and ischemic stroke in addition to the greatest effects of demographic, clinical, and behavioral risk factors. The key functional variation of the ACE gene that has drawn the most interest is the ACE I/D variant. Even though the ACE gene I/D polymorphism has been widely studied, the findings of investigations on the involvement of this polymorphism in ischemic stroke were contradictory and provide conflicting data. The goal of this study was to look into the effect of the ACE gene I/D polymorphism on the risk of ischemic stroke in patients with hypertension.MethodsA hospital-based case–control study was carried out in 36 cases of patients with hypertensive IS and 36 age- and sex-matched healthy controls. Clinical and biochemical parameters were measured to assess the associated risk factors. The DNA was isolated from blood samples, and the ACE I/D genotypes were identified using polymerase chain reaction and analyzed by agarose gel electrophoresis.ResultsThe ACE-DD genotype (OR = 3.71, 95% CI = 1.02–13.5; P < 0.05) and D allele (OR = 2.07, 95% CI = 1.06–4.03; P < 0.05) were significantly more common in patients than in controls, indicating that it is a risk factor for the development of ischemic stroke in hypertensive individuals.ConclusionThere is a significant correlation between the ACE gene I/D polymorphism and the development of ischemic stroke in patients with a history of hypertension in the Ethiopian population.

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Horiz Med (Lima) 2022; 22(4): e2175 7 genes distintos como causa primaria de la enfermedad, de las cuales 22 (59 %) fueron totalmente nuevas para la ciencia (7) . Otro aspecto interesante es la frecuencia de variantes genéticas que determina la respuesta (o no) a fármacos, que constituye la base de las llamadas "farmacogenética" y "medicina de precisión", y va a ser interesante conocer la predisposición de la población peruana a distintos tratamientos (8) .

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La europeización de la genética y una mirada a los peruanos

Fujita

2022

Horizmed

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Lack of association between angiotensin-converting enzyme (ACE) genotype and essential hypertension in Peruvian older people

Cited by 3 publications

References 21 publications

Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients

Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients

Angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of ischemic stroke complication among patients with hypertension in the Ethiopian population

La europeización de la genética y una mirada a los peruanos

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