Lack of association between
            <i>
              <scp>SLCO</scp>
              1B1
            </i>
            polymorphisms and lipid‐lowering response to simvastatin therapy in Thai hypercholesterolaemic patients

Kaewboonlert, N.; Thitisopee, Witsawat; Sirintronsopon, W.; Porntadavity, Sureerut; Jeenduang, Nutjaree

doi:10.1111/jcpt.12682

Cited by 7 publications

(13 citation statements)

References 41 publications

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“…According to the studies, investigations of parts area about SLCO1B1 are showed clearly: Geek, German, Indian (North) and Macedonian manifest the relatively lower rate of G allele in G388A, less than 50%, whereas Thailand and Chinese population show higher than former, generally above 70%. By contrast, the allele frequency exhibits little difference in SLCO1B1 gene 521T>C polymorphism (Dendramis, 2011;Giannakopoulou et al, 2014;Hubacek et al, 2015;Kaewboonlert et al, 2018;Melo et al, 2015;Meyer zu Schwabedissen et al, 2015;Mladenovska et al, 2017;Ramakumari et al, 2018;Treenert et al, 2018;Wu et al, 2018). In this study, the mutation allele frequency of SLCO1B1 gene 388A>G and 521T>C were 74.89% (74.64% in male and 75.30% in female) and 11.54% (12.14% in male and 10.57% in female) respectively.…”

Section: Discussionmentioning

confidence: 51%

Polymorphism analysis of APOE and SLCO1B1 genes in Meizhou area of southern China

et al. 2019

Preprint

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Background APOE and SLCO1B1 genetic polymorphisms are relevant in statin pharmacokinetics.Objective Aim of this study was to investigate the polymorphisms of APOE and SLCO1B1 gene in Meizhou area.Methods Genotying of APOE and SLCO1B1 genetic polymorphisms were conducted in 4761 individuals.Results Among two variants of SLCO1B1 in Meizhou, the frequencies of 388A>G and 521T>C allele were 74.89% and 11.54% separately. The frequency of SLCO1B1 gene hplotype *1b/*1b was 40.37% followed by *1a/*1b (31.93%) and *1b/*15(14.14%). There were no significant differences between men and women in this study except SLCO1B1 521T>C ( SLCO1B1 521TT, P =0.019; SLCO1B1 521TC, P =0.028) and haplotypes *1a/*15 of SLCO1B1 (*1a/*15, P=0.02). Moreover, the frequencies of APOE ɛ3/ɛ3 was 69.94%, followed by 15.77% in ɛ3/ɛ4, 11.30% in ɛ2/ɛ3, 1.56% in ɛ2/ɛ4, 1.02% in ɛ4/ɛ4 and 0.54% in ɛ2/ɛ2, with considerably higher rate of allele ɛ3 (83.48%).Conclusions The population of Meizhou has different distribution feature. This study provides a reference to optimize the individualization of drug use in this area.

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Section: Discussionmentioning

confidence: 51%

Polymorphism analysis of APOE and SLCO1B1 genes in Meizhou area of southern China

et al. 2019

Preprint

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“…The comparison of our results with those of Hapmap Project [12] and other studies [4,5,11,13] is illustrated in Table 4. The genotype and allele frequencies of Turkish population demonstrated prominent dissimilars when compared to East Asian and Southeast ancestry.…”

Section: Discussionmentioning

confidence: 61%

“…They observed that no significant was distinction among three groups for genotype frequencies of SLCO1B1, and also there was no relationship between rs4363657 polymorphism in SLCO1B1 and risk of myalgia/myopathy in low doses of statin-treated Czech patients. In addition, Kaewboonlert et al [5] reported that there was no relationship between SLCO1B1 g.89595 T>C polymorphism and lipid-lowering response to 3 and 12 months of 20 or 40 mg/day simvastatin treatment in Thai patients with hypercholesterolaemia (n=391). It has been concluded that in lipid-lowering response to simvastatin treatment in Thai patients with hypercholesterolaemia, SLCO1B1 g.89595 T>C polymorphism should not be employed as the genetic markers.…”

Section: Discussionmentioning

confidence: 99%

“…Solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene which has alternative names SLC21A6, LST1, OATPC, OATP2 encodes organic anion transporter protein (OATP1B1) which is a membrane-bound sodium-independent protein [4]. OATP1B1 is particularly expressed in the human basolateral hepatocyte membrane [5], where it mediates active intracellular hepatic transport of diverse anionic substrates [4,6]. OATP1B1 is responsible for the hepatocellular uptake of not only xenobiotics like HIV protease inhibitors, HMG-CoA reductase inhibitors (statins) but also endogenous substrates like thyroid hormones, bile acids [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…One of these variant is SLCO1B1 g.89595 T>C polymorphism (rs4363657, intron 11). This polymorphism is reported to have almost complete linkage disequilibrium with SLCO1B1 c.521T>C (rs4149056) which is one of the most common variants of SLCO1B1 gene, but the linkage disequilibrium between these polymorphisms may differ between ethnicities [5].…”

Section: Introductionmentioning

confidence: 99%

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Genotype and allele frequencies of SLCO1B1 g.89595 T C polymorphism in a healthy Turkish population

Şahinoğulları¹,

Canacankatan²,

Canacankatan³

2019

Sanat

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Many xenobiotic and endogenous compounds are transported from blood into hepatocytes mediated by organic anion transporter protein (OATP1B1), which is encoded by solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene. Genetic polymorphisms in SLCO1B1 gene can affect in pharmacokinetics of most compounds and may cause changes in drug efficacy and advers reactions. Thus, genetic polymorphism analysis of genes that may affect the pharmacokinetics of compounds is extremely important. The goal of this study was to determine the genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population and also to compare our results with the findings of other previously reported populations. Genotyping analyses of SLCO1B1 g.89595 T>C polymorphism was carried out in 68 healthy Turkish volunteers by a polymerase chain reactionrestriction fragment length polymorphism method. The frequencies of the TT, TC, and CC genotypes were 77.9, 19.1 and 3.0, respectively. Also, the frequencies of T and C alleles were 87.5 and 12.5, respectively. The genotype frequencies were consistent with Hardy-Weinberg equilibrium. The results of the study are compared with those of other ethnic groups, and they displayed pronounced ethnic group differences, especially East Asian and Southeast ancestry. The detection of SLCO1B1 polymorphisms may ensure benefits for adjustment of dosage regimens of some drugs and protecting from and/or decreasing adverse events, and also for future studies concerning SLCO1B1 transporter and its polymorphisms.

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Associations between four polymorphisms of the SLCO1B1 and effectiveness of the statins: a meta-analysis

Nguyen

Phuong

et al. 2023

Pharmacogenetics and Genomics

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Objective Statins are the first-choice therapy for dyslipidemia, but their effectiveness can be influenced by genetic polymorphisms. This study was conducted to assess the association of variants of the solute carrier anion transporter family 1B1 (SLCO1B1) gene, which encodes a transporter involving the hepatic clearance of the statins and their therapeutic efficacy. Method A systematic review was performed on four electronic databases to identify relevant studies. The pooled mean difference with 95% confidence interval (CI) in percentage change of concentration of LDL-C, total cholesterol (TC), HDL-C, and triglycerides was calculated. Heterogeneity between studies and publication bias, subgroup analyses, and sensitivity analyses were also carried out using R software. Results Twenty-one studies on 24 365 participants and four variants [rs4149056 (c.521T>C), rs2306283 (c.388A>G), rs11045819 (c.463C>A), rs4363657 (g.89595T>C)] were analyzed. A statistically significant association was found between the LDL-C-lowering effectiveness and the rs4149056 and rs11045819 in the heterozygote model; and the rs4149056, rs2306283, and rs11045819 in the homozygote model. In the subgroup analyses, non-Asian populations, simvastatin, and pravastatin showed significant associations between LDL-C-lowering efficacy and the rs4149056 or rs2306283. Significant associations between the rs2306283 and HDL-C-increasing effectiveness were found in the homozygote model. Regarding TC-reducing, significant associations were observed in the heterozygote and homozygote models of the rs11045819. There was no heterogeneity and publication bias among most studies. Conclusion SLCO1B1 variants can be used as signals to predict the statins’ effectiveness.

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Lack of association between SLCO 1B1 polymorphisms and lipid‐lowering response to simvastatin therapy in Thai hypercholesterolaemic patients

Abstract: SLCO1B1 c.388A>G, c.521T>C and g.89595T>C polymorphisms may not be useful as genetic markers of lipid-lowering response to simvastatin therapy in Thai hypercholesterolaemic patients.

Cited by 7 publications

References 41 publications

Polymorphism analysis of APOE and SLCO1B1 genes in Meizhou area of southern China

Polymorphism analysis of APOE and SLCO1B1 genes in Meizhou area of southern China

Genotype and allele frequencies of SLCO1B1 g.89595 T C polymorphism in a healthy Turkish population

Associations between four polymorphisms of the SLCO1B1 and effectiveness of the statins: a meta-analysis

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