Lack of Association Between Transforming Growth Factor Beta 1-509C/T and +915G/C Polymorphisms and Chronic Hepatitis B in Iranian Patients

Razavi, Armin Hosseini; Azimzadeh, Pedram; Mohebbi, Seyed Reza; Hosseini, Seyed Masoud; Romani, Sara; Khanyaghma, Mahsa; Hatami, Yasin; Sharifian, Afsaneh; Zali, Mohammad Reza

doi:10.5812/hepatmon.13100

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…In a different tune, Kimura et al have demonstrated − 509C allele to be associated with a higher clearance rate of HCV as well as with lower promoter activity ( Kimura et al, 2006 ). However, in the contest of hepatitis B and Iranian patients, absence of association between TGF-β1 − 509C > T and + 915G > C polymorphisms with chronic hepatitis B indicated that these changes do not play a significant role in increasing the risk of chronic infection in Iranian patients ( Razavi et al, 2014; Romani et al, 2011 ). Our finding of TGF-β1 polymorphism at position − 509 with increase in C > T genotype in the patient group suggests its protective role, since all the patients recovered.…”

Section: Discussionmentioning

confidence: 99%

TGF-β1 gene −509C>T promoter polymorphism modulates TGF-β1 levels in hepatitis E patients

Rathod

Tripathy

2015

Meta Gene

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Elevated levels of transforming growth factor-β1 (TGF-β1) and its positive correlation with Foxp3 expression in hepatitis E patients have indicated involvement of TGF-β1 in hepatitis E pathogenesis. The current study determined polymorphisms in TGF-β1 gene, plasma TGF-β1 levels and T effector (Teff) cell proliferation and explored their association in a case control study. Polymorphisms in three selected sites (− 509C > T, + 869T > C and + 915G > C) of TGF-β1 gene by PCR & restriction fragment length polymorphism methods, plasma TGF-β1 quantitation by ELISA and Teff (CD4 + CD25 −) cell proliferation by CFSE method were carried out in 277 hepatitis E patients (HE) with self-limiting infection and 233 ethnically matched healthy controls (HCs) from western India. Frequency of CT genotype of − 509C > T site was significantly higher in hepatitis E patients compared to healthy controls (p = 0.017; OR 1.53, 95% CI 1.07–2.17). Plasma TGF-β1 levels were significantly higher in HE compared to HCs. TGF-β1 level of patient group having CT genotype of − 509C > T site was significantly higher compared to those having CC or TT genotypes. Teff cell proliferation was negatively correlated with plasma TGF-β1 levels in HE patients (r = − 0.568; p = 0.014). Influence of TGF-β1 promoter (− 509C > T) polymorphism on plasma TGF-β1 levels and inverse correlation of Teff cell proliferation with plasma TGF-β1 levels in self-limiting hepatitis E patients suggest key role of TGF-β1 in augmentation of reported T regulatory cell mediated pathogenesis in hepatitis E.

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Section: Discussionmentioning

confidence: 99%

TGF-β1 gene −509C>T promoter polymorphism modulates TGF-β1 levels in hepatitis E patients

Rathod

Tripathy

2015

Meta Gene

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“…The enrolled subjects were individuals referred to the Taleghani hospital of Tehran from January 2010 to October 2011. The cases and controls sample size was calculated based on a previously published formula ( 26 , 27 ). Informed consent was obtained from all subjects at the time of enrollment and the ethical review boards of the institution approved the study protocol.…”

Section: Methodsmentioning

confidence: 99%

A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients

Behelgardi

Hosseini

Mohebbi

et al. 2015

Jundishapur J Microbiol

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Background:Interleukin-16 (IL-16) is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases such as hepatitis B, which is a major health concern worldwide.Objectives:In this study, we aimed to investigate the plausible association between IL-16 polymorphism and chronic HBV susceptibility in an Iranian population.Patients and Methods:In a case-control study, we analyzed rs1131445 polymorphism in the microRNA binding site of the IL-16 gene in 262 patients with chronic hepatitis B and 269 healthy controls, using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and DNA sequencing technology to confirm our results.Results:Altogether, in this investigation, a significant association was observed between the IL-16 TC genotype compared with the TT genotype (OR = 0.696, 95% CI: 0.485 - 0.997, P = 0.048), after adjustments for confounders including age and gender.Conclusions:These findings show that immunogenetic factors, such as single nucleotide polymorphism in IL-16, could be a risk factor for susceptibility to chronic HBV infection. However, further investigations are needed to verify these results.

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“…Recent studies have shown that C-509T gene polymorphisms in the promoter region of TGF-β1 are associated with plasma levels (Hosseini Razavi et al, 2014 ). Similarly, the TGF-β1 T869C polymorphism affects the secretion of TGF-β1, suggesting that the polymorphic variants of TGF-β1 might influence cancer risk (Peng et al, 2011 ).…”

Section: Dysregulation Of Tgf-β In H Pylori -Indumentioning

confidence: 99%

Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis

Xie

Lü

2015

Front. Cell. Infect. Microbiol.

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Helicobacter pylori (H.pylori) is a Gram-negative, microaerophilic, helical bacillus that specifically colonizes the gastric mucosa. The interaction of virulence factors, host genetic factors, and environmental factors contributes to the pathogenesis of H. pylori-associated conditions, such as atrophic gastritis and intestinal metaplasia. Infection with H. pylori has recently been recognized as the strongest risk factor for gastric cancer. As a pleiotropic cytokine, transforming growth factor (TGF)-β regulates various biological processes, including cell cycle, proliferation, apoptosis, and metastasis. Recent studies have shed new light on the involvement of TGF-β signaling in the pathogenesis of H. pylori infection. This review focuses on the potential etiological roles of TGF-β in H. pylori-mediated gastric pathogenesis.

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Lack of Association Between Transforming Growth Factor Beta 1-509C/T and +915G/C Polymorphisms and Chronic Hepatitis B in Iranian Patients

Cited by 5 publications

References 26 publications

TGF-β1 gene −509C>T promoter polymorphism modulates TGF-β1 levels in hepatitis E patients

TGF-β1 gene −509C>T promoter polymorphism modulates TGF-β1 levels in hepatitis E patients

A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients

Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis

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