A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients

Behelgardi, Abbas; Hosseini, Seyed Masoud; Mohebbi, Seyed Reza; Azimzadeh, Pedram; Derakhshani, Shaghayegh; Karimi, Khatoon; Sharifian, Afsaneh; Zali, Mohammad Reza

doi:10.5812/jjm.23411

Cited by 6 publications

(7 citation statements)

References 36 publications

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“…Many manifestations have shown that cytokines are one of the host’s most significant immunological factors, playing a crucial role in modulating the intensity and duration of the immune response (25). These soluble polypeptides also act as a defense against viral infections through driving the Th1/Th2 responses or by inhibiting viral replication (9, 11).…”

Section: Discussionmentioning

confidence: 99%

Interferon Gamma Gene Polymorphism (+874 T > A) and Chronic Hepatitis B in the Population of Gorgan, North-Eastern Iran

Ghasemian

Shahbazi

2016

Jundishapur J Microbiol

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BackgroundBased on differences in individual immune responses to the hepatitis B virus (HBV), between 5% and 10% of patients become persistently infected with the virus, which leads to the determination of chronic HBV. Cytokines such as interferon gamma (IFN-γ) are secretory proteins that play important roles in both innate and adaptive immune responses. Functional studies have demonstrated that the IFN + 874A/T gene polymorphism can increase or decrease the overall expression of IFN-gamma (γ) and ultimately determine the outcome of the infection.ObjectivesThis study was performed to investigate the relationship between the IFN-γ + 874 gene polymorphism and susceptibility to chronic HBV infection.MethodsPolymorphism detection analysis was performed on 598 subjects from North-Eastern Iran. The IFN-γ gene polymorphism (+ 874A/T) was genotyped through a specific sequence primer polymerase chain reaction (SSP-PCR).ResultsThe frequencies of the AA, AT, and TT genotypes were 31%, 51%, and 18% in the chronic HBV patient group, and 40%, 45%, and 15% in the healthy control group, respectively. However, a lack of association of the + 874 polymorphism in the IFN-γ gene of those with chronic HBV infection was found. Evaluation of HBV association with this polymorphism was significant under the dominant genetic model (P = 0.04).ConclusionsUltimately, no association could be characterized between the polymorphism in IFN-γ + 874A/T and susceptibility to chronic HBV infection in this segment of the Iranian population (P > 0.05).

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Section: Discussionmentioning

confidence: 99%

Interferon Gamma Gene Polymorphism (+874 T > A) and Chronic Hepatitis B in the Population of Gorgan, North-Eastern Iran

Ghasemian

Shahbazi

2016

Jundishapur J Microbiol

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“…Therefore, several recent studies have paid attention to the effect of gene polymorphisms of cytokines on infectious disease outcome, response to vaccination and treatment. Polymorphisms in genes encoding cytokines may be the primary cause of clinical differences between patients; hence they can be used for the identification of individuals who are at high risk of developing hepatocellular carcinoma and chronic hepatitis (3,36). So far, we have evaluated the association of several genes with hepatitis and cancer (27,(47)(48)(49)(50)(51).…”

Section: Discussionmentioning

confidence: 99%

“…Amongst hepatitis viruses, hepatitis B virus (HBV), the prototype member of a family of Hepadnaviridae (1), can cause lifelong infection with a worldwide distribution and is endemic in many populations (2)(3)(4). Infection with HBV can lead to a wide range of diseases such as chronic hepatitis, acute hepatitis, asymptomatic HBV carriers, liver cirrhosis and primary hepatocellular carcinoma (HCC) (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

Zangi

Bakhshandeh

Mehrpouya

et al. 2019

Jundishapur J Microbiol

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Background: The most common primary cause of liver cancer is hepatocellular carcinoma (HCC). Cytokines as mediators have significant roles in immune and inflammatory responses. Interleukin-13 (IL-13) is a potent pleiotropic cytokine. Objectives: The aim of this study was to evaluate the association of IL-13/+110 gene polymorphism in patients with chronic hepatitis B virus (HBV), one of the most important factors that lead to the development of HCC. Methods: DNA was extracted from peripheral blood cells of all 585 participants including 302 unrelated Hepatitis B surface antigen (HBS-Ag) positives and 283 healthy matched groups. The IL-13 gene polymorphism (+ 110 A or G) was genotyped by SSP-PCR method and then genotype frequencies were checked by using the Pearson's chi-square test and/or Fisher exact test. Results: The frequencies of A/G genotype (CI = 1.18-2.34, OR = 1.66, P = 0.004) and A/A genotype (CI = 0.95-3.53, OR = 1.84, P = 0.071) were higher in the patients. Also, the frequency of A allele was remarkably higher in the HBV patients than control group (CI = 1.09-1.79, OR = 1.84, P = 0.071). Conclusions: High frequency of A allele in patients rather than control group suggested that A allele probably plays a role in augmenting susceptibility to HBV infection risk and high frequency of G allele in controls suggested this allele has a protective role in this disease.

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“…Behelgardi et al ( 83 ) studied the influence of IL-16 T/C (rs1131445), an SNP located in a miRNA-binding site in 3′UTR of the IL-16 gene, and the risk of HBV chronic infection in an Iranian population. After adjustment for covariates, including age and gender, the TC genotype was associated with an increased risk of HBV chronic infection.…”

Section: Viral Infections and Polymorphic Variants That Affect Mirnasmentioning

confidence: 99%

MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications

2018

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MicroRNAs (miRNAs) are single-stranded sequences of non-coding RNA with approximately 22 nucleotides that act posttranscriptionally on gene expression. miRNAs are important gene regulators in physiological contexts, but they also impact the pathogenesis of various diseases. The role of miRNAs in viral infections has been explored by different authors in both population-based as well as in functional studies. However, the effect of miRNA polymorphisms on the susceptibility to viral infections and on the clinical course of these diseases is still an emerging topic. Thus, this review will compile and organize the findings described in studies that evaluated the effects of genetic variations on miRNA genes and on their binding sites, in the context of human viral diseases. In addition to discussing the basic aspects of miRNAs biology, we will cover the studies that investigated miRNA polymorphisms in infections caused by hepatitis B virus, hepatitis C virus, human immunodeficiency virus, Epstein–Barr virus, and human papillomavirus. Finally, emerging topics concerning the importance of miRNA genetic variants will be presented, focusing on the context of viral infectious diseases.

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A Study on Genetic Association of Interleukin-16 Single Nucleotide Polymorphism (rs1131445) With Chronic Hepatitis B Virus Infection in Iranian Patients

Cited by 6 publications

References 36 publications

Interferon Gamma Gene Polymorphism (+874 T > A) and Chronic Hepatitis B in the Population of Gorgan, North-Eastern Iran

Interferon Gamma Gene Polymorphism (+874 T > A) and Chronic Hepatitis B in the Population of Gorgan, North-Eastern Iran

Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications

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