Lack of association between vitamin D receptor genes BsmI as well as ApaI polymorphisms and osteoporosis risk: A pooled analysis on Chinese individuals

Abstract

In conclusion, this meta-analysis suggests that VDR Tru9I polymorphism may be associated with osteoporosis risk in Chinese individuals, while BsmI, ApaI polymorphisms might not be a risk factor for osteoporosis.

Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

“…During literature search, we identified seven metaanalyses [15,[118][119][120][121][122][123] investigating the relationship between VDR gene polymorphisms and osteoporosis.…”

“…BsmI polymorphism studies were included in all seven meta-analyses. In six meta-analyses, no significant association was found between osteoporosis susceptibility and BsmI polymorphism [15,[118][119][120][121][122]. Zhang et al [123] conducted a meta-analysis of the risk of osteoporosis in postmenopausal women with 36 studies including 7192 subjects and found a marginally significant association (OR bvs.B = 1.2; CI = 1.00-1.46; p = 0.052).…”

“…In all the meta-analyses, a low between study heterogeneity was found in all the studies except the study conducted by Yu et al [120]. ApaI polymorphism was included in four meta-analyses [118,120,122,123]. Zintzaras et al [118], Yu et al [120], Wang et al [122], and Zhang et al [123] included seven, six, three, and eighteen studies, respectively, in their meta-analyses, and all four studies reported no association between ApaI polymorphism and osteoporosis risk.…”

“…ApaI polymorphism was included in four meta-analyses [118,120,122,123]. Zintzaras et al [118], Yu et al [120], Wang et al [122], and Zhang et al [123] included seven, six, three, and eighteen studies, respectively, in their meta-analyses, and all four studies reported no association between ApaI polymorphism and osteoporosis risk. Zintzaras et al [118] and Zhang et al [123] conducted meta-analyses of three and 18 studies of FokI polymorphism, and no significant association was found between FokI polymorphism and osteoporosis.…”

Vitamin D receptor (VDR) geneFokI,BsmI,ApaI andTaqI polymorphisms and osteoporosis risk: a meta-analysis

“…Down syndrome [16], neural tube defects [104], Glucose 6phosphate dehydrogenase deficiency [105], depression [106], schizophrenia [107], Alzheimer [108], breast cancer [109], colorectal cancer [110], esophageal cancer [111] and prostate cancer [112] etc. During literature search we identified seven meta-analyses [15,[113][114][115][116][117][118] investigating the relationship VDR gene polymorphism and osteoporosis. BsmI, ApaI, FokI and TaqI polymorphism were included in seven, four, two and two meta-analyses respectively.…”