Lack of association of IL-12 p40 gene polymorphism with peptic ulcer disease

García-González, María Asunción; Lanas, Ángel; Wu, Jing; Benito, Rafael; Santolaria, Santos; Crusius, Bart; Peña, Salvador

doi:10.1016/j.humimm.2004.10.003

Cited by 16 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this sense, Sánchez et al [40] suggested that polymorphisms in the IL12B gene may not play a relevant role in the susceptibility to or severity of SLE in the Spanish population. Moreover, the IL12B polymorphism rs3212227 is not involved in the susceptibility to and final outcome of peptic ulcer disease in Spanish patients [41]. However, an association was observed for IL23R rs11209026 and susceptibility to disease in patients with ankylosing spondylitis, multiple sclerosis, and celiac disease [38,39].…”

Section: Discussionmentioning

confidence: 89%

“…In addition, Nair et al [34] observed that the polymorphism rs7530511 was associated with psoriasis, while the other, rs6887695, was not. Polymorphisms in IL12B and IL23R have been studied in Spanish patients with other inflammatory diseases such as inflammatory bowel disease [37], multiple sclerosis, celiac disease [38], ankylosing spondylitis [39], systemic lupus erythematosus (SLE) [40] and peptic ulcer disease [41]. No association was reported in patients with inflammatory bowel disease [37].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients

Cabaleiro¹,

Román²,

Gallo³

et al. 2013

European Journal of Dermatology

View full text Add to dashboard Cite

Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients Background & Objectives: Susceptibility to psoriasis has been associated with the HLA-C*0602 allele, although it may be affected by other polymorphisms. Materials & Methods: We genotyped 142 patients and 160 healthy volunteers to evaluate the possible relationship between susceptibility to psoriasis and the HLA-C*0602 allele and polymorphisms in the TNF, IL12B, and IL23R genes. Results: The frequency of the wild-type TNF-238, TNF-308, and TNF-1031 genotypes was greater in patients with psoriasis than in healthy volunteers, although that of the mutant TNF-857 genotype was higher. The only difference between psoriasis and psoriatic arthritis was TNF-857. The frequency of the HLA-C*0602 allele was higher in psoriatic patients than in healthy volunteers. No differences were observed for IL12B and IL23R. Multivariate logistic regression analysis only confirmed these associations for TNF-238, TNF-857, and HLA-C*0602. Conclusion: Our results support an association between susceptibility to psoriasis and TNF polymorphisms in the Spanish population.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients

Cabaleiro¹,

Román²,

Gallo³

et al. 2013

European Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…The variation at IFNG +2109A/G creates a restriction site for the enzyme AciI and was genotyped by a previously reported PCR-RFLP method [21]. The IL12B +1188 genotyping was performed using a PCR-RFLP method in accordance with García-González et al [22]. Fluorescence-based TaqMan technology (Applied Biosystems, Foster City, CA, USA) was applied to produce genotypes of IL17A and TGFB1 polymorphisms according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment

Peresi

Oliveira

Silva

et al. 2013

Tuberculosis Research and Treatment

View full text Add to dashboard Cite

Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 −819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.

show abstract

“…In a study conducted with 110 patients with noncardia GC and 251 patients with benign gastroduodenal diseases, NAVAGLIA et al (2005) reported no correlation between IL-12 gene polymorphisms and IM; however, IL12A and IL12B+15485gene polymorphisms might affect the latest steps of gastric carcinogenesis in H. pylori infected subjects. GARCIA-GONZÁLEZ et al (2005) reported no significant differences between peptic ulcer patients and controls in carriage, genotype, sex, and allele frequencies of the IL-121188 gene polymorphism (GARCIA-GONZALEZ et al, 2005) In another study conducted in Spanish population, GARCIA-GONZALEZ et al (2005) could not find a relationship between cytokine polymorphisms (IL-1B, IL-1RN, IL-12p40, LTA, IL-10, IL-4, and TGF-B1) and susceptibility for GC development (GARCIA-GONZALEZ et al, 2007). YIN et al (2015) conducted a hospital based case-control study to evaluate the genetic effects of IL9, IL10, IL12A, IL12B, and IL13 polymorphisms on the development of gastric cardiac adenocarcinoma (GCA).…”

Section: Resultsmentioning

confidence: 99%

Association of interleukin 12B rs3212227 polymorphism with gastric cancer, intestinal metaplasia, and helicobacter pylori infection

et al. 2020

View full text Add to dashboard Cite

Interleukin 12 (IL-12) has a key function in promoting Th1 immune response in the gastrointestinal mucosa. Although cytokine gene polymorphisms are associated with increased risk of gastric cancer (GC), studies on different geographic regions and ethnic groups are not able to draw a consistent result. The current case-control study aims to find out an association between a functional IL-12B rs3212227 polymorphism and the susceptibility and clinical features of the study groups, which are GC, Helicobacter pylori-infected and H. pylori-uninfected intestinal metaplasia (IM). In this study, IL-12B rs3212227 polymorphism was genotyped in 35 GC cases, 25 H. pylori-infected IM patients, 25 H. pylori-uninfected IM patients, and 25 control subjects. PCR-RFLP analysis was performed to find out and compare the polymorphism profiles of case biopsies. There was statistical significance in genotype distributions and allelic frequencies in GC patients with proximal arrest in stomach (p=0.042). The rs3212227 genotypes and allelic frequencies were not correlated with any of the study groups (p>0.05). Other clinical features examined in the GC patients were also not correlated with the rs3212227 genotypes and allelic frequencies (p>0.05). Current findings suggest that IL-12B rs3212227 polymorphism may play a role in GC development.

show abstract

Lack of association of IL-12 p40 gene polymorphism with peptic ulcer disease

Cited by 16 publications

References 30 publications

Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients

Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients

Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment

Association of interleukin 12B rs3212227 polymorphism with gastric cancer, intestinal metaplasia, and helicobacter pylori infection

Contact Info

Product

Resources

About