2014
DOI: 10.1186/1471-2474-15-376
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Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis

Abstract: BackgroundEpidemiological studies have investigated the association between matrix metalloproteinase-3(MMP-3) gene-1171 5A/6A polymorphism and rheumatoid arthritis (RA), but the results were inconsistent. To evaluate the specific relationship, we performed a meta-analysis to clarify the controversies.MethodsThe relevant literatures dated to December 07th 2013 were retrieved from PubMed, EMBASE and the China National knowledge Infrastructure (CNKI) databases. The number of the alleles and genotypes for MMP-3 we… Show more

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Cited by 4 publications
(6 citation statements)
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“…However, there is considerable controversy over the association between MMP-1 gene polymorphism and OA. In essence, OA is the most common cause of synovial joint tissue inflammation, leading to the progressive destruction of cartilage and bone [22].…”
Section: Discussionmentioning
confidence: 99%
“…However, there is considerable controversy over the association between MMP-1 gene polymorphism and OA. In essence, OA is the most common cause of synovial joint tissue inflammation, leading to the progressive destruction of cartilage and bone [22].…”
Section: Discussionmentioning
confidence: 99%
“…Однако в метаанализе, проведенном Z. Feng и соавт. [23] не выявлено ассоциативных связей с развитием РА. Авторы считают это вероятным следствием нескольких причин: во-первых, РА -сложное заболевание, в развитии которого помимо различных внешних факторов принимают участие множество генов.…”
Section: Discussionunclassified
“…В-третьих, возможно влияние пока не выясненных генетических факторов на развитие болезни. Поэтому авторы считают целесообразным дальнейшие исследования полиморфизма MMP3 5A/6A при РА [23]. Необходимо отметить, что в настоящее время отсутствуют единые подходы к констатации наличия ВП и их дефинициям [24].…”
Section: Discussionunclassified
“…Among the more than 20 types of MMP genes, MMP-3 and MMP-8 are the most influential. MMP-3 encodes an enzyme that degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans [ 14 ]. MMP-8 is involved in the breakdown of the extracellular matrix in embryonic development, reproduction, and tissue remodeling [ 15 ].…”
Section: Introductionmentioning
confidence: 99%