Lack of correlation between CRP and hepatitis B viral load in serum of patients with chronic HBV

Gedik, Murat; Özbek, Erdal; Atmaca, Selahattin; Yilmaz, Şerif

doi:10.1016/j.jinf.2006.04.009

Cited by 9 publications

(9 citation statements)

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“…In line with the results of the present study, Gedik et al in 2006 indicated no significant correlation between CRP level and HBV viral load in patients with chronic HBV infection (13). Also, in a study carried out by Yilmaz et al the serum level of hs-CRP differed between hepatitis and control groups, although this difference was not statistically significant.…”

Section: Discussionsupporting

confidence: 87%

“…In addition, Yuan et al showed that serum hs-CRP concentration can be used as an inflammatory marker for the diagnosis of patients with chronic and severe HBV infection, accompanied by spontaneous bacterial peritonitis (4). On the other hand, the results of a study by Gedik et al indicated no significant correlation between serum CRP level and serum HBV viral load in patients with chronic HBV infection (13).…”

Section: Introductionmentioning

confidence: 89%

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Diagnostic Value of the Quantitative Titer of High-Sensitivity C-Reactive Protein in the Detection of Clinical Stages of Chronic Hepatitis B Infection

Metanat¹,

Tabatabaei²,

Alenabi³

et al. 2016

Int J Infect

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 89%

Diagnostic Value of the Quantitative Titer of High-Sensitivity C-Reactive Protein in the Detection of Clinical Stages of Chronic Hepatitis B Infection

Metanat¹,

Tabatabaei²,

Alenabi³

et al. 2016

Int J Infect

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“…We found that CRP and hsCRP levels were elevated in patients with HBV compared with controls and HBV DNA levels were correlated with hsCRP levels, but Gedik et al [16] described a lack of correlation between CRP and hepatitis B viral load in serum of patients with chronic HBV. There are no other studies reporting quantitative comparison of HBV DNA and hsCRP values [17].…”

Section: Discussionmentioning

confidence: 64%

Elevation of B-Type Natriuretic Peptide Level in Asymptomatic Hepatitis B Virus-Positive Patients Is Not Associated with Abnormalities of Cardiac Function

Küçükazman¹,

Ata²,

Yavuz

et al. 2011

Med Princ Pract

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Objectives: To compare B-type natriuretic peptide (BNP) and echocardiographic parameters in patients with hepatitis B virus (HBV) and healthy control subjects. Subjects and Methods: 52 consecutive patients with HBV and 47 healthy controls were examined. All subjects underwent transthoracic echocardiography after a complete medical history and laboratory examination including BNP, C-reactive protein (CRP) and high-sensitivity CRP (hsCRP). Results: Demographic characteristics were similar in patients with HBV and the control group. No significant difference was found in conventional Doppler and tissue Doppler parameters between the two groups. BNP levels were significantly higher in patients with HBV [6.5 ng/l (range 0.5-85.2)] than controls [4.3 ng/l (range 0.5-18.3)], p = 0.039. hsCRP [3.25 mg/l (0.02-40.2) vs. 0.5 mg/l (0.02-8.0)] levels were significantly higher in patients with HBV than control subjects (p < 0.001). Conclusion: Patients with HBV had higher BNP, CRP, and hsCRP levels than controls. Echocardiographic findings were similar in both groups. This slight BNP elevation in HBV patients may be related to chronic inflammation due to HBV.

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“…The investigators have detected that CRP was higher than the normal level in 5 (12,1%) of the 41 sera positive for anti-HCV in hemodialysis patients. 10 Our study group have detected that there was no correlation between hsCRP rates and viral load in patients with hepatitis B, in a previous study 11 .…”

Section: Discussionmentioning

confidence: 69%

Correlation of high sensitive C-reactive protein and Hepatitis C Virus RNA in anti-HCV-positive sera

Özekinci¹

2011

Dicle Med J

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ÖZET Amaç: HCV antikoruna sahip kişilerden elde edilen se-rumlarda HCV RNA'nın pozitif ve negatifliğine göre ka-raciğerden salgılanan hsCRP düzeyinin farklılık belirlen-mesidir. Gereç ve yöntem: Klinik olarak Hepatit-C şüpheli olup anti-HCV'si pozitif tespıt edilen toplam 84 hasta çalışma-ya dahil edildi. Anti HCV'si pozitif 84 örnek, HCV RNA sonuçlarına göre; HCV RNA'sı pozitif grup (Grup 1, 50 örnek) ve HCV RNA'sı negatif grup (Grup 2, 34 örnek) olmak üzere iki gruba ayrıldı. Bulgular: HCV'si pozitif 84 örneğinin 50'sinde HCV RNA pozitif (Grup 1), 34'ünde HCV RNA negatif (Grup 2) ola-rak tespit edildi. 1.grupta 50 serum örneğinin 11'de (%22), 2.grupta 34 serum örneğinin 3'de (%8.8) hsCRP değer-leri normal değerin üzerinde tespit edildi. Sonuç: Örneklerin sayısal olarak karşılaştırıldığında Grup 1 lehine istatistiksel olarak anlamlı bulundu (p<0,001). Buna karşılık iki gruptan elde edilen hsCRP değerlerinin kantitatif ortalamalarının karşılaştırılmasında elde edilen sonuçlar istatistiki olarak anlamsız bulundu (P>0.05). Anahtar kelimeler: HCV, hsCRP, ilişki ABSTRACT Objectives: To determine whether the level of high sensitive C-reactive protein (hsCRP) secreted from liver differed according to the positivity and negativity of the HCV RNA in sera collected from individuals with HCV antibod-ies. Materials and methods: A total of 84 patients with clinically suspected Hepatitis C were included in this study, in which anti-HCV was detected to be positive. Eighty four anti-HCV positive samples were divided into two groups according to the HCV RNA results, as the HCV RNA positive group (Group 1, 50 samples) and the HCV RNA negative group (Group 2, 34 samples). Results: 50 of the 84 samples with anti HCV positivity were detected to be positive for HCV RNA (Group 1), whereas 30 were detected as negative (Group 2). While the hsCRP values were found to be above the normal level in 11 (22%) of the 50 sera samples in the first group, and in 3 (8,8%) of the 34 sera samples in the second group. Conclusion: Numerical comparison of the hsCRP positive samples revealed a statistically significant result in favor of group 1 (p<0,001). On the other hand, results obtained from comparison of the quantitative hsCRP mean values obtained from the two groups were found to be statistically insignificant (P>0.05).

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Lack of correlation between CRP and hepatitis B viral load in serum of patients with chronic HBV

Cited by 9 publications

References 0 publications

Diagnostic Value of the Quantitative Titer of High-Sensitivity C-Reactive Protein in the Detection of Clinical Stages of Chronic Hepatitis B Infection

Diagnostic Value of the Quantitative Titer of High-Sensitivity C-Reactive Protein in the Detection of Clinical Stages of Chronic Hepatitis B Infection

Elevation of B-Type Natriuretic Peptide Level in Asymptomatic Hepatitis B Virus-Positive Patients Is Not Associated with Abnormalities of Cardiac Function

Correlation of high sensitive C-reactive protein and Hepatitis C Virus RNA in anti-HCV-positive sera

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