Lack of D2 receptor mediated regulation of dopamine synthesis in A11 diencephalospinal neurons in male and female mice

Pappas, Samuel S.; Behrouz, Bahareh; Janis, Kelly; Goudreau, John L.; Lookingland, Keith J.

doi:10.1016/j.brainres.2008.03.010

Cited by 23 publications

(32 citation statements)

References 55 publications

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“…Assuming that RLS is primarily a sensory disorder, this action alone may explain the thera peutic actions of dopaminergics completely independent of any need for central dopamine dysfunction . This would be consistent with the apparent absence of D 2 -like autoreceptor function on descending dopaminergic terminals [78] . The possibility of a spinal site of action is further provided by studies with the D 3 KO mouse.…”

Section: A11 Dopamine Dopamine Receptors and Spinal Circuits In Relsupporting

confidence: 75%

“…Further studies are warranted to confirm these hypotheses in humans, especially in light of the apparent species-specific expression of dopamine receptor subtypes in the spinal cord [60] . Independent of the A11 being dopaminergic, as discussed above, or possibly only L-dopa-ergic [60,78,84] , there is little doubt that A11 stimulation produces spinal antinociceptive actions via D 2 -like receptor selective mechanisms [77,84,85] .…”

Section: A11 Dopamine Dopamine Receptors and Spinal Circuits In Relmentioning

confidence: 99%

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Possible Sites of Therapeutic Action in Restless Legs Syndrome: Focus on Dopamine and α2δ Ligands

et al. 2011

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Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by abnormal sensations that occur primarily at rest or during sleep, which are alleviated by movement of the affected limb. The pathophysiology of RLS remains unclear, although roles for dopamine dysfunction and brain iron deficiency have been proposed. The hypothalamic A11 dopaminergic circuit is used to explain the dopamine dysfunction in RLS and the potential therapeutic actions of dopamine D2 agonists. Modulation of central and peripher- al neuronal circuits may also explain the potential therapeutic sites of action of opioids, adenosine receptor ligands, and voltage-gated calcium channel α2δ ligands in RLS. The known and possible therapeutic benefits of these agents and their relationship to dopaminergic dysfunction in RLS are discussed in this review.

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Section: A11 Dopamine Dopamine Receptors and Spinal Circuits In Relsupporting

confidence: 75%

Section: A11 Dopamine Dopamine Receptors and Spinal Circuits In Relmentioning

confidence: 99%

Possible Sites of Therapeutic Action in Restless Legs Syndrome: Focus on Dopamine and α2δ Ligands

et al. 2011

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“…It is important to note however that some dopamine neurons differentially express D 2 autoreceptors. The mechanisms of actions at the soma and terminals may also be different (G protein-coupled inwardly-rectifying potassium channel (GIRK) versus Kv1.2 respectively) and some TH + neurons may not even express them at all (Pappas et al, 2008; Ford, 2014). Therefore, expression of D 2 autoreceptors may not be a pre-requisite of a canonical dopamine cell, but may be a common feature.…”

Section: Catecholamine-containing Cellsmentioning

confidence: 99%

“…The predominant sources of spinal dopamine and noradrenaline in mammals are the descending fibers projecting from the dopaminergic A10 and A11 nuclei of the posterior hypothalamus (Björklund and Skagerberg, 1979; Lindvall et al, 1983; Skagerberg and Lindvall, 1985; Qu et al, 2006; Pappas et al, 2008), the A13 of the dorsal hypothalamus (Blessing and Chalmers, 1979) and the pontine noradrenergic A5, A6 (locus coeruleus) and A7 nuclei (Fritschy and Grzanna, 1990; Clark and Proudfit, 1991; Bruinstroop et al, 2012). While these regions appear to be conserved in many mammalian species including primates and humans (Moore and Bloom, 1979; Barraud et al, 2010), we will focus on these regions with emphasis on rodent anatomy as they are best described in these species.…”

Section: Descending Catecholaminergic Projectionsmentioning

confidence: 99%

“…This suggests a possibility that L-DOPA release in the spinal cord of the non-human primate could be converted to dopamine by other cells using spinally located AADC such as that present in the D cells near the central canal (Jaeger et al, 1983). It appears that dopaminergic neurons in the A11 go against what a canonical dopaminergic neuron would look like, since A11 neurons lack the reuptake transporter DAT (Lorang et al, 1994; Ciliax et al, 1999) as well as D 2 auto-receptors (Pappas et al, 2008). The lack of D 2 autoreceptors would presumably increase release probability for dopamine as well as TH enzyme activity (Kehr et al, 1972; Wolf and Roth, 1990; Benoit-Marand et al, 2001; Ford, 2014).…”

Section: Descending Catecholaminergic Projectionsmentioning

confidence: 99%

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Dopamine: a parallel pathway for the modulation of spinal locomotor networks

Sharples

Koblinger

Humphreys

et al. 2014

Front. Neural Circuits

109

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The spinal cord contains networks of neurons that can produce locomotor patterns. To readily respond to environmental conditions, these networks must be flexible yet at the same time robust. Neuromodulators play a key role in contributing to network flexibility in a variety of invertebrate and vertebrate networks. For example, neuromodulators contribute to altering intrinsic properties and synaptic weights that, in extreme cases, can lead to neurons switching between networks. Here we focus on the role of dopamine in the control of stepping networks in the spinal cord. We first review the role of dopamine in modulating rhythmic activity in the stomatogastric ganglion (STG) and the leech, since work from these preparations provides a foundation to understand its role in vertebrate systems. We then move to a discussion of dopamine’s role in modulation of swimming in aquatic species such as the larval xenopus, lamprey and zebrafish. The control of terrestrial walking in vertebrates by dopamine is less studied and we review current evidence in mammals with a focus on rodent species. We discuss data suggesting that the source of dopamine within the spinal cord is mainly from the A11 area of the diencephalon, and then turn to a discussion of dopamine’s role in modulating walking patterns from both in vivo and in vitro preparations. Similar to the descending serotonergic system, the dopaminergic system may serve as a potential target to promote recovery of locomotor function following spinal cord injury (SCI); evidence suggests that dopaminergic agonists can promote recovery of function following SCI. We discuss pharmacogenetic and optogenetic approaches that could be deployed in SCI and their potential tractability. Throughout the review we draw parallels with both noradrenergic and serotonergic modulatory effects on spinal cord networks. In all likelihood, a complementary monoaminergic enhancement strategy should be deployed following SCI.

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Comparison of efficacy of arthroscopic lavage plus administration of corticosteroids, arthroscopic lavage plus administration of placebo, and joint aspiration plus administration of corticosteroids in arthritis of the knee: A randomized controlled trial

Oosterhout

Sont

Bajema

et al. 2006

Arthritis & Rheumatism

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Objective. To compare the efficacy of arthroscopic lavage plus administration of corticosteroids (ALC), arthroscopic lavage plus administration of placebo (ALP), and joint aspiration plus administration of corticosteroids (JAC) in knee arthritis, and to evaluate whether clinical or histologic characteristics determine outcome. Methods. Patients with knee arthritis (not due to gout, osteoarthritis, or septic arthritis) were randomized over 3 treatment arms: ALC, ALP, and JAC. The primary end point was event-free survival, with events defined as 1) recurrence or persistence of symptomatic knee swelling necessitating local re-treatment, or 2) nonimprovement of the knee joint score. Synovial tissue specimens were collected and analyzed histologically to identify predictive factors of responsiveness. Results. A total of 78 patients were enrolled; 3 patients did not receive their allocated therapy and 3 were lost to followup. The median time until recurrence was 9.6 months after ALC, 3.0 months after JAC, and 1.0 month after ALP, corresponding to a relative risk (RR) of arthritis recurrence of 2.2 for JAC (95% confidence interval [95% CI] 1.2-4.2, P ‫؍‬ 0.02) and 4.7 for ALP (95% CI 2.3-9.4, P < 0.0001) compared with ALC. A high versus low synovial extent of fibrosis conferred an RR for recurrence of 5.7 (95% CI 1.6 -20.5, P < 0.01) after ALC. Conclusion. Arthroscopic lavage plus administration of corticosteroids was more effective than arthroscopic lavage plus administration of placebo or joint aspiration plus injection of corticosteroids. The absence of fibrosis was a histologic predictor of a beneficial response.

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Lack of D2 receptor mediated regulation of dopamine synthesis in A11 diencephalospinal neurons in male and female mice

Cited by 23 publications

References 55 publications

Possible Sites of Therapeutic Action in Restless Legs Syndrome: Focus on Dopamine and α<sub>2</sub>δ Ligands

Possible Sites of Therapeutic Action in Restless Legs Syndrome: Focus on Dopamine and α<sub>2</sub>δ Ligands

Dopamine: a parallel pathway for the modulation of spinal locomotor networks

Comparison of efficacy of arthroscopic lavage plus administration of corticosteroids, arthroscopic lavage plus administration of placebo, and joint aspiration plus administration of corticosteroids in arthritis of the knee: A randomized controlled trial

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