Lack of Dietary Calcium Effect on Chlordecone Increased White Blood Cell Count, Total Iron, and Iron-Binding Capacity in Serum of Rat

Chetty, Kothapa N.; Fantroy, L.; Landau, G.; Ivie, G. Wayne

doi:10.1006/eesa.1996.0034

Cited by 3 publications

(1 citation statement)

References 1 publication

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“…However, this study is in variance with other works [12,17] that reported an increase in WBC when chlordecone was administered to male Sprague-Dawley rats [17] and when arsenic-poisoned cattle blood parameters were evaluated.…”

Section: Discussioncontrasting

confidence: 62%

The effect of calabash chalk on some hematological parameters in female adult Wistar rats

Akpantah¹,

Ibok²,

Ekong³

et al. 2010

Turk J Hematol

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Objective: Calabash chalk is a naturally occurring mineral consumed among the Nigerian community for pleasure and commonly by pregnant women as a remedy for morning sickness. Reports have shown that it contains different toxic substances, with lead being the most abundant. This study was therefore undertaken to ascertain the effect of two commonly available preparations of this chalk on some hematological parameters. Materials and Methods: Twenty-four adult female Wistar rats with average weight of 100 g were assigned into three groups (1, 2, 3). Group 1 served as the control and the animals received distilled water, while Groups 2 and 3 were treated by oral gavage with 40 mg/kg of non-salted (NSCC) and salted calabash chalk (SCC), respectively, for 14 days. Results: The hemoglobin (Hb) concentration and red blood cell (RBC) count were significantly (p<0.05, 0.001 respectively) lower in the NSCC group, while erythrocyte sedimentation rate (ESR) was significantly (p<0.05) higher in the NSCC group compared to the control. There were no significant differences in packed cell volume (PCV), white blood cell (WBC) and platelet (Pl) counts compared to the control. The SCC group presented no significant difference in all blood count parameters compared to the control. Conclusion: This infers that calabash chalk, particularly the non-salted form, alters the normal concentration of Hb, RBC and Pl counts, and ESR, as observed in the female Wistar rats studied. (Turk J Hematol 2010; 27: 177-81) Key words: Calabash chalk, blood parameters, wistar rat Received: December 19, 2008 Accepted: January 28, 2010 Özet Amaç: Kalabaş tebeşiri, genellikle gebe ve diğer kadınlar tarafından keyfi olarak ve sabah bulantısını iyileştirmek için tüketilen, doğan oluşumlu bir mineraldir. Başta kurşun olmak üzere farklı toksik maddeler içerdiği raporlarda gösterilmiştir. Dolayısıyla bu çalışmada, bu taşın en yaygın iki preparatının bazı hematolojik parametreler üzerindeki etkisinin belirlenmesi amaçlanmıştır.

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Section: Discussioncontrasting

confidence: 62%

The effect of calabash chalk on some hematological parameters in female adult Wistar rats

Akpantah¹,

Ibok²,

Ekong³

et al. 2010

Turk J Hematol

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Daily exposure to chlordecone, an organochlorine pesticide, increases cardiac fibrosis and atrial fibrillation vulnerability

Fundere,

Rose,

Xiong

et al. 2024

Journal of Hazardous Materials

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Interaction Between Pesticides and Essential Metal Copper Increases the Accumulation of Copper in the Kidneys of Rats

Panemangalore

Bebe

2005

BTER

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Male Sprague-Dawley rats, weighing 175-200 g, six per group were fed AIN 93M diet (CON) or diets containing 500 mg Ca (LCa), 7 mg Zn (LZn), 2 mg Cu (LCu), 60 mg Zn (HZn), or 12 mg Cu (HCu) per kilogram of diet in the following combinations: control (CON), LCa+LZn (LC+Z), LCa+LZn+LCu (LC+Z+C), or HZn+HCu (HZ+C) without or with a pesticides mixture (PM); Endosulfan, Thiram, and Acephate were added to the diets at 25% of LD50/kg. Rats were fed for 2 wk (small intestinal changes) or 4 wk (tissues changes). Plasma Zn was 47% lower than CON in the experimental groups. Plasma Cu and ceruloplasmin concomitantly decreased in the LC+Z+C group and increased with the addition of PM. Kidney Cu was 40% lower in LC+Z+C group, than CON and increased by 31% with PM; in the HZ+C+PM group, kidney Cu was 38% higher than the HZ+C group. Mucosal and small intestines Ca declined by 47% in all experimental groups; PM increased Zn in the LC+Z+C and HZ+C groups; PM further decreased intestinal and mucosal Cu retention in the LC+Z+C and HZ+C groups. Data suggest that low levels of PM in the diet can induce Cu accumulation in the kidney when dietary Zn and Cu are low or high.

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Lack of Dietary Calcium Effect on Chlordecone Increased White Blood Cell Count, Total Iron, and Iron-Binding Capacity in Serum of Rat

Cited by 3 publications

References 1 publication

The effect of calabash chalk on some hematological parameters in female adult Wistar rats

The effect of calabash chalk on some hematological parameters in female adult Wistar rats

Daily exposure to chlordecone, an organochlorine pesticide, increases cardiac fibrosis and atrial fibrillation vulnerability

Interaction Between Pesticides and Essential Metal Copper Increases the Accumulation of Copper in the Kidneys of Rats

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