Lack of Effect of Excess Glucocorticoid Hormone on the Rate of Dentin Deposition in Rats

Ball, Peter

doi:10.1177/00220345770560061901

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…The noted formation of new dendn was not affected by the surgical trauni.a of heart transplantadon, as these rats showed the same results as rats only receiving corticosteroids. The effects of the steroids given are in agreement with previous studies with regard to reducdon of body weight (3)(4)(5)(6)14) and functional survival time ofthe heart allograft (7).…”

Section: Discussionsupporting

confidence: 89%

“…Contradictory results are also found in studies of the effect of corticosteroids on rat incisors (2)(3)(4)(5). In the investigation by AN-NEROTH & BLOOM (2) excessive formation of bone-like substances and disorganized odontoblasts was found in the pulp chamber of the incisors after daily injections of corticosteroids in high doses (50 mg) for 8 days to adult rats.…”

Section: Discussionmentioning

confidence: 77%

“…In the investigation by AN-NEROTH & BLOOM (2) excessive formation of bone-like substances and disorganized odontoblasts was found in the pulp chamber of the incisors after daily injections of corticosteroids in high doses (50 mg) for 8 days to adult rats. BALL (3)(4)(5) showed that corticosteroids in low doses (0.4 mg) given to adult rats by weekly subcutaneous injection, for 1-5 wk, did not affect the mean width of dendn deposited. These different results found in incisors of steroid treated rats may, like the earlier mendoned contradictory results found in molars, be due to different amounts of cordcosteroids given.…”

Section: Discussionmentioning

confidence: 99%

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Effect of intravenous administration of corticosteroids on dentin formation in the adult rat molar

Näsström¹,

Petersson²,

Konrad

1989

European J Oral Sciences

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Nasstrom K, Petersson A, Konrad P: Effect of intravenous administration of corticosteroids on dentin formation in the adult rat molar. Scand J Dent Res 1989; 97: 301-6.Abstract -This study describes the effects of intravenously given corticosteroids on dentin formation in adult rat molars. Six rats twice a day received corticosteroids 20 mg/kg for 8 days, 10 mg/kg for 13 d.ays, and 5 mg/kg for 19 days. Six rats given a heterotopic heart transplant received 10 mg/kg of corticosteroids twice a day for 40-64 days. Six rats were used as controls. Tetracycline was given at the start .of ±e experiment and after 3 wk of treatment. After 40-46 days the rats were killed. Light microscopic examination of the molars showed no differences in the dentin formation or in the predentin zone between the experimental and control rats. In the ultraviolet light microscope two lines of tetracycline were visible along the root canal walls in both experimental groups. There was an obvious distance between the two lines, which indicated formation of new dentin. In the control grotip no formation of dentin was visible.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Effect of intravenous administration of corticosteroids on dentin formation in the adult rat molar

Näsström¹,

Petersson²,

Konrad

1989

European J Oral Sciences

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“…However, the results of animal experiments were not unanimous concerning GCs’ effect on dentin formation. Ball et al [ 31 – 33 ] observed in three trials that rats given subcutaneous injections of corticosteroids had narrower dentin walls, resulting in larger pulp chambers in the incisors. After administering corticosteroids to freshly weaned rats, Johannessen et al [ 34 ] discovered that dentin development in the molars was suppressed.…”

Section: Discussionmentioning

confidence: 99%

Generalized pulp canal obliteration in a patient on long-term glucocorticoids: a case report and literature review

et al. 2022

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Background The calcification of the tooth pulp is a pathological condition that occurs in response to various factors. A uncommon haematological condition known as paroxysmal nocturnal haemoglobinuria (PNH) is characterized by bouts of haemolysis, and it requires long-term use of glucocorticoids (GCs). Case presentation A female patient who was diagnosed with PNH and had a history of long-term use of GCs came to our department for root canal therapy (RCT) for teeth 25, 26, and 27. The radiographs showed generalized pulp canal obliteration (PCO) in most of the patients. None of these teeth (25, 26, or 27) were sensitive to percussion, and they did not respond to thermal or electrical sensitivity tests. A diagnose of pulp necrosis was made for these teeth. RCT was carried out with the help of an oral microscope, and then a prosthodontic procedure was created for the teeth. Conclusions Based on the patient’s long history use of GCs and a series of related studies, we conclude that the long-term usage of GCs contributes significantly to the onset of PCO.

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“…On the other hand, some authors represent the statement that during pre-functional eruptive phase and early functional eruptive phase of teeth can be recorded decrease of the rate of synthesis and release of dentin [15]. Other researchers accentuate on the role of corticosteroids for stimulation of apposition of abundant pre-dentin tissue, with parallel and subsequently organized and performed process of accomplishment of predentin mineralization [12,16].…”

Section: Advances In Dentistry and Oral Healthmentioning

confidence: 99%

Untitled

2019

ADOH

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It has been established that people accepting oral corticosteroids often suffer from lack of teeth or are characterized with caries-non-resistant dentition. Corticosteroids can affect the consistency of alveolar bone, causing its osteoporotic alteration related to reduction of osteoblasts and amount of osteoid matrix. Parallel to the application of corticosteroids, there is a tendency of decrease of the height of alveolar bone and fibrous transformation of the periodontal space. There can be established severe loss of supporting alveolar bone. Corticosteroids therapy interrelates to enhanced potential for clinical manifestation of alterations of taste sensation, periodontitis, gingivitis, ulceration, candidiasis, tooth decay, xerostomia. Authors have established that the prolonged use of corticosteroids is in direct ratio to elevated rate of incidence and progression of inflammatory disorders of the supporting periodontal apparatus. The pathophysiological mechanisms of disturbance of the function of local and systemic immunity, provoked and sustained by corticosteroids' therapy, lead to considerable increase of the distribution of periodontal disorders.

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Lack of Effect of Excess Glucocorticoid Hormone on the Rate of Dentin Deposition in Rats

Cited by 9 publications

References 9 publications

Effect of intravenous administration of corticosteroids on dentin formation in the adult rat molar

Effect of intravenous administration of corticosteroids on dentin formation in the adult rat molar

Generalized pulp canal obliteration in a patient on long-term glucocorticoids: a case report and literature review

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