Lack of efficacy of nebulized magnesium sulfate in treating adult asthma: A meta-analysis of randomized controlled trials

Ling, Zhougui; Wu, Yuzhang; Kong, Jinliang; Tang, Zhenming; Liu, Wei; Chen, Yiqiang

doi:10.1016/j.pupt.2016.09.008

Cited by 8 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies with an I 2 statistic between 25 and 50% were considered to have low heterogeneity, whereas studies with an I 2 statistic between 50 and 75% were considered to have moderate heterogeneity, and those with an I 2 statistic >75% were considered to have high heterogeneity [ 18 ]. If homogeneity was present, fixed- and random-effect models provided similar results; when substantial heterogeneity of the individuals (I 2 > 50%) was observed, a random-effect model only was used [ 19 ]. If heterogeneity was present, we performed a sensitivity analysis by omitting one study at a time to further explore the heterogeneity.…”

Section: Methodsmentioning

confidence: 99%

Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis

et al. 2017

Self Cite

View full text Add to dashboard Cite

ObjectiveWe performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs) in patients with lung cancer (LC).MethodsWe searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test.ResultsThe systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies. Enzyme-linked immunosorbent assay (ELISA) was the most common detection method. For the diagnosis of patients with all stages and early-stage LC, different single or combinations of TAAbs demonstrated different diagnostic values. Although individual TAAbs showed low diagnostic sensitivity, the combination of multiplex autoantibodies offered relatively high sensitivity. For the meta-analysis of a same panel of autoantibodies in patients at all stages of LC, the pooled results of the panel of 6 TAAbs (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1 and SOX2) were: sensitivity 38% (95% CI 0.35–0.40), specificity 89% (95% CI 0.86–0.91), diagnostic accuracy 65.9% (range 62.5–81.8%), AUC 0.52 (0.48–0.57), while the summary estimates of 7 TAAbs (p53, CAGE, NY-ESO-1, GBU4-5, SOX2, MAGE A4 and Hu-D) were: sensitivity 47% (95% CI 0.34–0.60), specificity 90% (95% CI 0.89–0.92), diagnostic accuracy 78.4% (range 67.5–88.8%), AUC 0.90 (0.87–0.93). For the meta-analysis of the same panel of autoantibodies in patients at early-stage of LC, the sensitivities of both panels of 7 TAAbs and 6 TAAbs were 40% and 29.7%, while their specificities were 91% and 87%, respectively.ConclusionsSerum single or combinations of multiplex autoantibodies can be used as a tool for the diagnosis of LC patients at all stages or early-stage, but the combination of multiplex autoantibodies shows a higher detection capacity; the diagnostic value of the panel of 7 TAAbs is higher than the panel of 6 TAAbs, which may be used as potential biomarkers for the early detection of LC.

show abstract

Section: Methodsmentioning

confidence: 99%

Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…A Cochrane review demonstrated reduced hospital admissions and a small improvement in lung function with the use of magnesium sulfate in the emergency department (81). A review by Ling et al, did not demonstrate any reduction in hospital admissions with the use of nebulized magnesium, and thus there is not a clear benefit of nebulised administration at this point (82).…”

Section: Magnesiummentioning

confidence: 99%

Mechanisms and Management of Asthma Exacerbations

Ramsahai

Hansbro

Wark

2019

Am J Respir Crit Care Med

116

View full text Add to dashboard Cite

Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma the presence of exacerbations is an important defining characteristic of asthma severity. In this review we will assess the epidemiology of acute asthma, the triggers of acute exacerbations and the mechanisms that underlie these exacerbations. We will also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this. Finally we will review current management strategies of the exacerbations themselves.

show abstract

“…The authors showed that there is no significant difference between the bronchodilatory effect of nebulized MgSO 4 and salbutamol in the management of acute asthma (Gonzalez et al, 2013[48]). In 2016, Ling and colleagues reported that nebulized MgSO 4 is not useful to improve pulmonary function or reduce the number of patients admitted to the hospital in adults with acute asthma (Ling et al, 2016[92]). In children, treatment with nebulized magnesium sulfate showed no significant effect on respiratory function or hospital admission and further treatment (Su et al, 2016[149]).…”

Section: Clinical Application Of Magnesium Sulfate In Icumentioning

confidence: 99%