2020
DOI: 10.1007/s00228-020-02849-5
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Lack of evidence for allopurinol for the prevention of a first gout attack in asymptomatic hyperuricemia: a systematic review

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Cited by 7 publications
(5 citation statements)
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“…Contrarily, a sudden reduction of SUA may also trigger a gout flare through the dissolution of MSU fallen off from tophi [83]. Allopurinol, a ULT medicine, has not shown any efficacy in the prevention of a first gout flare in patients with asymptomatic hyperuricemia [84]. Fundamentally, SUA level is associated with physical capacity and muscle strength in healthy subjects [23,24] and may only be a biological marker of non-gout conditions such as cardiovascular damage but is not a risk factor for its development [51].…”
Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning
confidence: 99%
“…Contrarily, a sudden reduction of SUA may also trigger a gout flare through the dissolution of MSU fallen off from tophi [83]. Allopurinol, a ULT medicine, has not shown any efficacy in the prevention of a first gout flare in patients with asymptomatic hyperuricemia [84]. Fundamentally, SUA level is associated with physical capacity and muscle strength in healthy subjects [23,24] and may only be a biological marker of non-gout conditions such as cardiovascular damage but is not a risk factor for its development [51].…”
Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning
confidence: 99%
“…Contrarily, a sudden reduction of SUA may also trigger gout attack through the dissolution of MSU to be fallen off from tophi [83]. Allopurinol, a ULT medicine, has not shown any efficacy in the prevention of a first gout attack in patients with asymptomatic hyperuricemia [84]. Fundamentally, SUA level is associated with physical capacity and muscle strength in healthy subjects [23,24] and may only be a biological marker of non-gout conditions such as cardiovascular damage but is not a risk factor for its development [51].…”
Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning
confidence: 99%
“…Urate-lowering agents have a secondary preventive effect against the recurrence of gout flares in hyperuricemic people who already have suffered from gout flares [ 11 ]. Recently, one review showed that no definite evidence proved that allopurinol use (one xanthine oxidase inhibitor) could be associated with reduced probability of the first gout flare in asymptomatic hyperuricemia [ 16 ].…”
Section: Introductionmentioning
confidence: 99%