Lack of IgG in a healthy adult: A rare case of dysgammaglobulinemia with undetectable serum IgG, IgA2, and IgE

Hammarström, Lennart; Holm, G.; Palmblad, Jan; Persson, Mats A. A.; Smith, C. I. Edvard

doi:10.1016/0090-1229(84)90001-1

Cited by 16 publications

(6 citation statements)

References 19 publications

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“…This deficiency might be a new type of immunological disorder which manifests itself mainly during pregnancy and childbirth [6], since the mothers themselves did not suffer from an increased rate of infections. A recent report has indicated that even a total deficiency of IgG antibodies can be compensated by an increased production of IgM and the IgG-deficient individual can thereby avoid recur rent infections [ 12], corroborating this theory.…”

supporting

confidence: 59%

Increased Frequency of High Serum IgM among Mothers of Infants with Neonatal Group-B Streptococcal Septicemia

Rundgren¹,

Christensen²,

Christensen³

1985

Int Arch Allergy Immunol

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Total serum IgM levels were studied in 84 mothers of infants with group-B streptococcal (GBS) septicemia/meningitis and compared to IgM concentrations in 91 parturients who were urogenital carriers of GBS but nevertheless gave birth to healthy infants. In all, 22 (27%) in the study group showed IgM levels above the arbitrarily selected limit of 2.40 g/l, in contrast to 12 (13%) of 91 controls (p = 0.02). Among the study group members whose infants were infected with GBS type III, 8 of 34 (24%) were high in serum IgM, compared to only 2 of 34 (6%) of the corresponding controls (p = 0.04). The total serum IgG levels did not differ between the two groups.

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supporting

confidence: 59%

Increased Frequency of High Serum IgM among Mothers of Infants with Neonatal Group-B Streptococcal Septicemia

Rundgren¹,

Christensen²,

Christensen³

1985

Int Arch Allergy Immunol

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“…In some cases, it also may occur as a consequence of abnormal T‐cell control or altered B‐cell function (6). Diminished T‐lymphocyte function directed to specific subclass induction or excessive T‐cell suppression may result in subclass deficiency (7).…”

Section: Discussionmentioning

confidence: 99%

“…Severe asthma may become associated with an increased susceptibility to infections if immunoglobulin or IgG subclass levels are suppressed as a result of various diseases or treatment‐associated conditions. Considering that many healthy individuals present with IgG subclass deficiencies (7,31), a direct relationship of these immunodeficiencies to infections should be considered with special care, especially with respect to the need for gamma globulin treatment. Some studies show an improvement of clinical conditions in patients with established immunodeficiencies upon treatment with gamma globulin (36).…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma

Lui

Oliveira

Diogo

et al. 2002

Pediatric Allergy Immunology

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It was the aim of this study to investigate possible dysfunctions of the humoral immune system in asthmatic children with frequent respiratory infections. Forty-one severe asthmatics (7-15 years of age), classified according to the Second Brazilian Consensus in Asthma (1998), were divided into two groups: group I (n = 12) had recurrent respiratory infections; and group II (n = 29) were without recurrent respiratory infections. Immunoglobulin (Ig)G, IgA and IgM levels (nephelometry), and IgE (radioimmunoassay) and IgG subclasses (enzyme-linked immunosorbent assay), were evaluated using standard methods. Asthmatics with recurrent infections presented with worse clinical evolution, an increased number of hospital admissions, and a higher need of medication than the children without recurrent infections. There were no significant differences between the mean values of IgG, IgA or IgM levels, or IgE or IgG subclasses, in patients of both groups. A complete IgA deficiency was detected in two patients of group I (one was associated with IgG subclass deficiency). Deficiency of one or more IgG subclasses was verified in eight of 12 (66%) children from group I and in 16/29 (55%) from group II. The following deficiencies were found in both groups: IgG3 (10/41), IgG4 (three of 41), IgG2 (two of 41), IgG1 (one of 41), IgG3-IgG4 (four of 41), IgG1-IgG3 (two of 41), and IgG1-IgG3-IgG4 (one of 41). There were a higher proportion of children with low IgG4 levels in group I than in group II (p = 0.01). To conclude, IgA and IgG subclass deficiencies were detected in both severely asthmatic groups, with a predominance of IgG3 subclass deficiency. However, low IgG subclass levels appear not to be a suitable predictor of the development of infections in asthmatic children.

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“…Furthermore, T cells from SIgAD patients will support IgA production in vitro by B cells from normal subjects. In a few selected cases the defect is restricted to one of the two IgA subclasses and this is most often, although not invariably [ 26], due to deletions of the corresponding heavy chain constant region gene [ 27].…”

Section: Molecular Basismentioning

confidence: 99%

Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)

Hammarström¹,

Vořechovský

Webster

2000

Clinical and Experimental Immunology

375

260

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Lack of IgG in a healthy adult: A rare case of dysgammaglobulinemia with undetectable serum IgG, IgA2, and IgE

Cited by 16 publications

References 19 publications

Increased Frequency of High Serum IgM among Mothers of Infants with Neonatal Group-B Streptococcal Septicemia

Increased Frequency of High Serum IgM among Mothers of Infants with Neonatal Group-B Streptococcal Septicemia

Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma

Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)

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