Lack of in vitro Genotoxicity of Povidone-Iodine in Solution, in Ointment or in a Liposomal Formulation (Repithel&lt;sup&gt;®&lt;/sup&gt;)

Müller, Gerald; Hai, D.N.; Kramer, A. E. J. L.

doi:10.1159/000090103

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…In accordance with this, in histological tests, no tissue damage was observed in the treatment of chronic exudative wounds [167]. There is no evidence of neurotoxicity, mutagenicity, carcinogenicity, or teratogenicity [156,168]. In the cell culture (fibroblasts), 0.45% C-I was found to be noncytotoxic [167].…”

Section: Iodophorementioning

confidence: 90%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Section: Iodophorementioning

confidence: 90%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

View full text Add to dashboard Cite

show abstract

“…1 The Panel reviewed newly available studies since that assessment, along with updated information regarding types and concentration of use. 2 –26 The Panel confirmed that PVP is safe as a cosmetic ingredient in the practices of use and concentration as given in Table 1 and did not reopen the safety assessment.…”

Section: Resultsmentioning

confidence: 91%

PVP (Polyvinylpyrrolidone)

Burnett¹

2017

Int J Toxicol

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“…At concentrations of 10% Repithel®, 5% Betaisodona® ointment and 2.5% Betaisodona® solution in culture medium (60% cytotoxicity within 4 h of contact with CHO-K1 cells), no significant increase in the CA levels compared with negative control was observed. Hence, all tested concentrations of povidone-iodine formulations were not genotoxic in the CA test and the comet assay (34). The cytotoxicity of iodine-containing drugs was relatively low -after 30 min contact time using vital dye neutral red, the following IC 50 were determined: 16-18% Repithel®, 8-9% Betaisodona® ointment and 1.8-2% Betaisodona® solution (35).…”

Section: Genotoxicity Of Iodine and The Compounds Containing Iodinementioning

confidence: 88%

Toxicology of iodine: A mini review

Il’in¹,

Nersesyan

2013

Arch Oncol

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Iodine is necessary for all living organisms. Deficiency of iodine in the organism leads to various diseases (including mental) and increased rates of cancer. It is well known that one third of the world's population lived in iodine-deficient areas. At present time, the primary intervention for preventing iodine deficiency disorders worldwide is through the iodization of salt. The two most common types of fortificant used to iodize salt are potassium iodide and potassium iodate. Iodine-containing compounds are also widely used in clinical medicine as a highly effective topical antimicrobial agent that has been used clinically in the treatment of wounds. Hence, the genetic toxicology of iodine and iodine-containing compounds is very essential topic. In this literature review are analyzed the data concerning genetic toxicology and the influence of these compounds on tumor rates in epidemiological and experimental studies.

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Lack of in vitro Genotoxicity of Povidone-Iodine in Solution, in Ointment or in a Liposomal Formulation (Repithel<sup>®</sup>)

Cited by 8 publications

References 13 publications

Consensus on Wound Antisepsis: Update 2018

Consensus on Wound Antisepsis: Update 2018

PVP (Polyvinylpyrrolidone)

Toxicology of iodine: A mini review

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