Lack of ‘occult’ hepatitis B virus infection in HIV-infected patients

Núñez, Marina; Ríos, Pilar; Pérez‐Olmeda, Mayte; Soriano, Vincent

doi:10.1097/00002030-200210180-00024

Cited by 72 publications

(29 citation statements)

References 18 publications

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“…Occult hepatitis prevalence data reported in "antiHBs alone" HIV-positive patients varies greatly from 0% to 89.5% [1][2][3]9,12,17,20,21] . However, in those studies that have found viral replication, detected viral load was usually very low (< 10 3 copies/mL) [3,20] .…”

Section: Discussionmentioning

confidence: 99%

“…More than 90% of doctors that attend HIV patients follow this practice [22] . However, the latest recommendations in HIV-positive patients with the "anti-HBc alone" pattern advise to test for HBV DNA in every patient [6,10,12,13,20] . We believe that HBV DNA testing should be performed only in those patients with an unexplained high level of alanine aminotransferase (ALT) or signs of liver disease.…”

Section: Discussionmentioning

confidence: 99%

“…HBV DNA positive markers without HBV surface antigen (HBsAg), among patient with a defective immunological response. Some authors consider the "anti-HBc alone" pattern to be a marker of occult HBV infection [1,3,8,9] , whereas others have not been able to demonstrate HBV DNA in the sera of these patients [10][11][12][13] . This work was carried out to establish the prevalence and clinical significance of the "anti-HBc alone" pattern among HIV-positive patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of "anti-HBc alone" in human immunodeficiency virus-positive patients

Pérez-Rodríguez

Sopeña²,

Crespo³

et al. 2009

WJG

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AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection ("anti-HBc alone") among human immunodeficiency virus (HIV) type-1 infected patients. Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed. Patients with serological markers of hepatitis B virus (HBV) infection were classified into three groups: past hepatitis, "anti-HBc alone" and chronic hepatitis. Determination of DNA from HBV, and RNA and genotype from hepatitis C virus (HCV) were performed on "anti-HBc alone" patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of "anti-HBc alone" in human immunodeficiency virus-positive patients

Pérez-Rodríguez

Sopeña²,

Crespo³

et al. 2009

WJG

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“…The reported prevalence of OBI among these patients varied significantly from 0%-89% [120][121][122] . Study conducted in Brazil [123] found that immune suppression in HIV-infected patients was not a determining factor for development of OBI.…”

Section: Hbv/hcv Co-infected Patientsmentioning

confidence: 99%

Clinical implications of hepatitis B virus mutations: Recent advances

Lazarević¹

2014

WJG

125

108

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Hepatitis B virus (HBV) infection is a major cause of acute and chronic hepatitis, and of its long-term complications. It is the most variable among DNA viruses, mostly because of its unique life cycle which includes the activity of error-prone enzyme, reverse transcriptase, and the very high virion production per day. In last two decades, numerous research studies have shown that the speed of disease progression, reliability of diagnostic methods and the success of antiviral therapy and immunization are all influenced by genetic variability of this virus. It was shown that mutations in specific regions of HBV genome could be responsible for unwanted clinical outcomes or evasion of detection by diagnostic tools, thus making the monitoring for these mutations a necessity in proper evaluation of patients. The success of the vaccination programs has now been challenged by the discovery of mutant viruses showing amino acid substitutions in hepatitis B surface antigen (HBsAg), which may lead to evasion of vaccine-induced immunity. However, the emergence of these mutations has not yet raised concern since it was shown that they develop slowly. Investigations of HBV genetic variability and clinical implications of specific mutations have resulted in significant advances over the past decade, particularly in regard to management of resistance to antiviral drugs. In the era of drugs with high genetic barrier for resistance, on-going monitoring for possible resistance is still essential since prolonged therapy is often necessary. Understanding the frequencies and clinical implications of viral mutations may contribute to improvement of diagnostic procedures, more proper planning of immunization programs and creating the most efficient therapeutic protocols.

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“…A prevalência da infecção oculta do HBV pode ser afetada por vários fatores, dentre os quais a própria prevalência do HBV, a população estudada e a sensibilidade do método diagnóstico utilizado (28) . Por exemplo, a incidência de infecção oculta de HBV pode variar de 0-15% em indivíduos com anti-HBc positivo e a taxa dessa infecção foi reportada entre 0-89% em pacientes que vivem com HIV (29,30) . Ainda, a infecção oculta do HBV pode chegar a 36% em pacientes em hemodiálise (31) .…”

Section: Epidemiologiaunclassified

Avaliação dos desfechos virológicos e de adesão ao tratamento antiviral em pacientes portadores de hepatite B crônica

Abreu¹

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Ao Prof. Dr. Raymond Schinazi, que aceitou coorientar essa pesquisa e recebeu-me em seu laboratório na Emory University por seis meses, em Atlanta -EUA. Foi uma honra trabalhar com ele durante esse período e fazer parte do seu grupo. Em especial, gostaria de agradecer à Profa. Dra. Leda Bassit, por seus ensinamentos e orientações, imprescindíveis para a realização desse trabalho. À Dra. Lilia Ganova-Raeva e ao Dr. Yury Khudyakov (Centers for Disease Control and Prevention -EUA), agradeço pela valiosa ajuda em biologia molecular e apoio ao projeto. Aos pacientes, principal motivação desta pesquisa."A doença é o lado escuro da vida, uma cidadania mais onerosa. Todos que nascemos temos essa dupla cidadania, no reino da saúde e no reino da doença. Embora todos gostaríamos de usar só o bom passaporte, mais cedo ou mais tarde, cada um de nós é obrigado, pelo menos por um tempo, a se identificar como cidadãos daquele outro lugar." Susan Sontag, .

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Lack of ‘occult’ hepatitis B virus infection in HIV-infected patients

Cited by 72 publications

References 18 publications

Clinical significance of "anti-HBc alone" in human immunodeficiency virus-positive patients

Clinical significance of "anti-HBc alone" in human immunodeficiency virus-positive patients

Clinical implications of hepatitis B virus mutations: Recent advances

Avaliação dos desfechos virológicos e de adesão ao tratamento antiviral em pacientes portadores de hepatite B crônica

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