Lack of prepubertal administration of ethinyl estradiol on susceptibility to multiple organ carcinogenesis in rats exposed to 7,12-dimethylbenz[a]anthracene and N-bis(2-hydroxypropyl)nitrosamine during adolescence

Estetrol prevents and suppresses mammary tumors induced by DMBA in a rat model

“…This difference suggests that EE has no effect on tumor initiation, whereas E4 has an inhibitory effect on initiation and on tumor growth. Our results with EE in the prevention study are in agreement with those of Lemon [27] and Cho et al [41] using the DMBA model. In addition, our results with EE in Table 2 Slope estimate (SD) of log-transformed sum of total mammary tumor volumes during 4 weeks of treatment (intervention study).…”