Lack of Relationship between Cord Serum Angiopoietin-Like Protein 4 (ANGPTL4) and Lipolytic Activity in Human Neonates Born by Spontaneous Delivery

Ortega-Senovilla, Henar; Schaefer-Graf, Ute M.; Meitzner, Katrin; K, Graf; Abou-Dakn, Michael; Herrera, Emilio

doi:10.1371/journal.pone.0081201

Cited by 6 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under non-pregnant conditions such as fasting 28 , exercise 29 and diabetic insulin-resistance 10 , 30 , ANGPTL4 has been related to their active adipose tissue lipolysis. However, in agreement with previous studies 11 , we did not find here any relationship between the plasma concentration of NEFAs with ANGPTL4. In addition, plasma concentrations of NEFAs and glycerol were independent of GWG, not supporting the contention that alterations in lipolysis caused by the changes in ANGPTL4 concentration, could be responsible for the differences observed in GWG.…”

Section: Discussionsupporting

confidence: 93%

“…Recently, we reported that in both well-controlled gestational diabetes mellitus (GDM) and healthy control women, decreased maternal ANGPTL4 concentrations is associated with increased neonatal fat mass although its concentrations in cord blood serum were independent of neonatal fat mass 10 . Human studies produced inconsistent findings regarding the notion of ANGPTL4 to act as a signal preventing fat storage, and there are also studies that failed to find an association between ANGPTL4 and TAG or non-esterified fatty acid (NEFA) concentrations 11 , 12 . Moreover, serum ANGPTL4 concentrations has been found higher in obese subjects without/with type 2 diabetes mellitus relative to control subjects 13 , and variants of ANGPTL4 are associated with lower plasma TAG and higher waist circumference 14 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity

Ortega-Senovilla

Poppel

Desoyé

et al. 2018

Sci Rep

Self Cite

View full text Add to dashboard Cite

Angiopoietin-like protein 4 (ANGPTL4) is a circulating protein involved in the regulation of adipose tissue metabolism. However, its role in obesity and pregnancy is unknown. To evaluate the relationship between gestational weight gain (GWG) and circulating concentrations of ANGPTL4 in pregnant women with overweight and obesity, weight gain and fasting maternal blood samples of thirty-one pregnant women was drawn at 15, 24 and 32 weeks of gestation. ANGPTL4 concentrations continuously rose throughout gestation, whereas VEGF and leptin did not show the same trend. NEFA and glycerol concentrations remained stable during pregnancy. In contrast, total concentrations of saturated, monounsaturated and n-6 fatty acids, but not n-3 fatty acids, increased with pregnancy. In multiple regression analysis, the increase in plasma ANGPTL4 and decrease in linoleic acid concentrations were the most significant predictors of GWG, although only ANGPTL4 was significantly associated with the weight gain from early pregnancy (area under the ROC curve was 0.80 p < 0.01(95% CI 0.61–0.99)). In conclusion, in pregnant women with overweight and obesity, an increase in plasma ANGPTL4 concentrations throughout pregnancy is positively associated with GWG and could be used as an early marker of increased susceptibility to excess gestational weight gain.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity

Ortega-Senovilla

Poppel

Desoyé

et al. 2018

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cortisol: 1 ( 20 ), 2 ( 21 ), 3 ( 22 ), 4 ( 23 ), 5 ( 24 ), 6 ( 25 ), 7 ( 26 ), 8 ( 27 ), 9 ( 28 ), 10 ( 29 ), 11 ( 30 ), 12 ( 31 ), 13 ( 32 ), 14 ( 33 ), 15 ( 34 ), 16 ( 35 ), 17 ( 36 ), 18 ( 37 ), 19 ( 38 ), 20 ( 39 ), 21 ( 40 ), 22 ( 41 ), 23 ( 42 ), 24 ( 43 ), 25 ( 44 ), 26 ( 45 ), 27 ( 46 ), 28 ( 47 ), 29 ( 48 ), 30 ( 49 ), 31 ( 50 ), 32 ( 51 ), 33 ( 52 ), 34 ( 53 ), 35 ( 54 ), 36 ( 55 ), 37 ( 56 ), 38 ( 57 ), 39 ( 58 ), 40 ( 59 ), 41 ( 60 ), 42 ( 61 ), 43 ( 62 ), 44 ( 63 ), 45 ( 64 ), 46 ( 65 ), and 47 ( 66 ); Norepinephrine: 1 ( 67 ), 2 ( 68 ), 3 ( 33 ), 4 ( 69 ), 5 ( 70 ), 6 ( 71 ), 7 ( 72 ), 8 ( 73 ), 9 ( 74 ), 10 ( 36 ), 11 ( 75 ), 12 ( 76 ), 13 ( 77 ), 14 ( 78 ), 15 ( 79 ), 16 ( 80 ), 17 ( 81 ), 18 ( 55 ), and 19 ( 66 ); and AVP: 1 ( 11 ), 2 ( 12 ), 3 ( 15 ...…”

Section: Surge In Fetal Stress Hormonesmentioning

confidence: 99%

Arginine Vasopressin and Copeptin in Perinatology

Evers

Wellmann

2016

Front. Pediatr.

View full text Add to dashboard Cite

Arginine vasopressin (AVP) plays a major role in the homeostasis of fluid balance, vascular tonus, and the regulation of the endocrine stress response. The measurement of AVP levels is difficult due to its short half-life and laborious method of detection. Copeptin is a more stable peptide derived from the same precursor molecule, is released in an equimolar ratio to AVP, and has a very similar response to osmotic, hemodynamic, and stress-related stimuli. In fact, copeptin has been propagated as surrogate marker to indirectly determine circulating AVP concentrations in various conditions. Here, we present an overview of the current knowledge on AVP and copeptin in perinatology with a particular focus on the baby’s transition from placenta to lung breathing. We performed a systematic review of the literature on fetal stress hormone levels, including norepinephrine, cortisol, AVP, and copeptin, in regard to birth stress. Finally, diagnostic and therapeutic options for copeptin measurement and AVP functions are discussed.

show abstract

“…Angptl4 functions as a matricellular protein and by inhibiting lipoprotein lipase (LPL), Angptl4 increases serum trigylceride levels [ 57 ]. Although Angplt 4 is seen as a physiological mediator of intracellular adipose tissue lipolysis, serum Angptl4 levels do not always correlate with plasma triglyceride levels [ 58 ]. It has already been demonstrated that hematopoietic stem cells (HSCs) express PIRB, and PIRB therefore may function as sensor of inflammation through binding to the inflammatory Angptl4 and protecting HSCs from excessive activation and exhaustion [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy

et al. 2015

View full text Add to dashboard Cite

BackgroundUpon inflammation, myeloid cell generation in the bone marrow (BM) is broadly enhanced by the action of induced cytokines which are produced locally and at multiple sites throughout the body.MethodsUsing microarray studies, we found that Angptl4 is upregulated in the BM during systemic inflammation.ResultsRecombinant murine Angptl4 (rmAngptl4) stimulated the proliferation of myeloid colony-forming units (CFUs) in vitro. Upon repeated in vivo injections, rmAngptl4 increased BM progenitor cell frequency and this was paralleled by a relative increase in phenotypically defined granulocyte-macrophage progenitors (GMPs). Furthermore, in vivo treatment with rmAngptl4 resulted in elevated platelet counts in steady-state mice while allowing a significant acceleration of reconstitution of platelets after myelosuppressive therapy. The administration of rmAngptl4 increased the number of CD61+CD41low-expressing megakaryocytes (MK) in the BM of steady-state and in the spleen of transplanted mice. Furthermore, rmAngptl4 improved the in vitro differentiation of immature MKs from hematopoietic stem and progenitor cells. Mechanistically, using a signal transducer and activator of transcription 3 (STAT3) reporter knockin model, we show that rmAngptl4 induces de novo STAT3 expression in immature MK which could be important for the effective expansion of MKs after myelosuppressive therapy.ConclusionWhereas the definitive role of Angptl4 in mediating the effects of lipopolysaccharide (LPS) on the BM has to be demonstrated by further studies involving multiple cytokine knockouts, our data suggest that Angptl4 plays a critical role during hematopoietic, especially megakaryopoietic, reconstitution following stem cell transplantation.Electronic supplementary materialThe online version of this article (doi:10.1186/s13045-015-0152-2) contains supplementary material, which is available to authorized users.

show abstract

Lack of Relationship between Cord Serum Angiopoietin-Like Protein 4 (ANGPTL4) and Lipolytic Activity in Human Neonates Born by Spontaneous Delivery

Cited by 6 publications

References 45 publications

Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity

Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity

Arginine Vasopressin and Copeptin in Perinatology

Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy

Contact Info

Product

Resources

About