Lack of renal changes in stainless steel welders exposed to chromium and nickel.

Vyskočil, Adolf; Smejkalová, Jana; Tejral, Jaroslav; Emminger, S.; Vincentova, M.; Ettlerová, E; Lauwerys, Robert; Bernard, Alfred

doi:10.5271/sjweh.1581

Cited by 14 publications

(4 citation statements)

References 15 publications

(12 reference statements)

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“…The determination of Cys-C and Cre was described in the "Materials and Methods". The coeYcient value and related statistical signiWcance were calculated with the software of SPSS 13.0 as described in the text induce the kidney damage, controversial arguments always exist (Littorin et al 1984;Verschoor et al 1988;Vyskocil et al 1992). Thus, large number of samples and the comprehensive analysis presented in this study would promote better understanding the chronic renal injury following Cr occupational exposure.…”

Section: Discussionmentioning

confidence: 99%

Renal impairment caused by chronic occupational chromate exposure

Wang

Jia

Zhang

et al. 2010

Int Arch Occup Environ Health

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Section: Discussionmentioning

confidence: 99%

Renal impairment caused by chronic occupational chromate exposure

Wang

Jia

Zhang

et al. 2010

Int Arch Occup Environ Health

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“…Verschoor et al [27], Vyskocil et al [28], Saner et al [21], and Littorin et al [12] did not observe any sign of renal tubular damage in tannery, chrome plating, or welding workers. However, Mutti et al [15] reported an increased frequency of enzymuria and proteinuria when urinary chromium concentrations averaged 24.5 lg/g cre.…”

Section: Excretion Of Urinary Proteins and Enzymes Can Be In-mentioning

confidence: 93%

“…However, this does not mean that this injury does not occur. The question as to whether chronic exposure to chromium compounds can induce nephrotoxic eects remains controversial [4,11,12,15,20,27,28]. Low-molecular-weight proteinuria in chromium workers arises as a result of chronic low-level exposure to chromium [11].…”

Section: Introductionmentioning

confidence: 99%

Urinary N -acetyl-β-glucosaminidase as an indicator of renal dysfunction in electroplating workers

Liu

Kuo

Lai

et al. 1998

International Archives of Occupational and Environmental Health

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“…82 However, a study of workers exposed to high ambient air levels (mean 0.75 mg Ni/m 3 , range 0.04-2.86 Ni/m 3 ) that substantially exceeded the recommended TLV-TWA, demonstrated subclinical changes in renal tubular function. welders exposed to concentrations ranging from 2-78 µg Cr/g creatinine and 1.3-19 µg Ni/g creatinine, no doserelated alterations of renal tubular function were detected.…”

Section: Kidneymentioning

confidence: 97%

Nickel

Barceloux¹

1999

Journal of Toxicology: Clinical Toxicology

249

137

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Nickel is an essential element for at least several animal species. These animal studies associate nickel deprivation with depressed growth, reduced reproductive rates, and alterations of serum lipids and glucose. Although there is substantial evidence of an essential status for nickel in animals, a deficiency state in humans has not been clearly defined. Nickel is a silver-white metal with siderophilic properties that facilitate the formation of nickel-iron alloys. In contrast to the soluble nickel salts (chloride, nitrate, sulfate), metallic nickel, nickel sulfides, and nickel oxides are poorly water-soluble. Nickel carbonyl is a volatile liquid at room temperature that decomposes rapidly into carbon monoxide and nickel. Drinking water and food are the main sources of exposure for the general population with the average American diet containing about 300 micrograms Ni/d. Nickel is highly mobile in soil, particularly in acid soils. There is little evidence that nickel compounds accumulate in the food chain. Nickel is not a cumulative toxin in animals or in humans. Almost all cases of acute nickel toxicity result from exposure to nickel carbonyl. The initial effects involve irritation of the respiratory tract and nonspecific symptoms. Patients with severe poisoning develop intense pulmonary and gastrointestinal toxicity. Diffuse interstitial pneumonitis and cerebral edema are the main cause of death. Sodium diethyldithiocarbamate is an investigational drug used to chelate nickel following exposure to nickel carbonyl. Nickel is a common sensitizing agent with a high prevalence of allergic contact dermatitis. Nickel and nickel compounds are well-recognized carcinogens. However, the identity of the nickel compound or compounds, which cause the increased risk of cancer, remains unclear. Currently, there are little epidemiological data to indicate that exposure to metallic nickel increases the risk of cancer, or that exposure to the carcinogenic forms of nickel causes cancer outside the lung and the nasal cavity.

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Lack of renal changes in stainless steel welders exposed to chromium and nickel.

Cited by 14 publications

References 15 publications

Renal impairment caused by chronic occupational chromate exposure

Renal impairment caused by chronic occupational chromate exposure

Urinary N -acetyl-β-glucosaminidase as an indicator of renal dysfunction in electroplating workers

Nickel

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