Lack of specificity of the acid perfusion test in duodenal ulcer patients

Moraes-Filho, de

doi:10.1007/bf01071936

Cited by 27 publications

(3 citation statements)

References 11 publications

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“…Fewer reports have correlated symptoms, the histology of oesophagus, stomach, and duodenum and their relationship to each other in biopsies taken simultaneously.8 9 The purpose of this study was to assess whether there was a correlation between the symptoms of duodenal ulceration, severe enough to require operation, and the microscopical appearances of the duodenum, antrum, and oesophagus in biopsies taken at the time of surgery during a truncal vagotomy and pyloroplasty.…”

mentioning

confidence: 96%

Histological appearances of oesophagus, antrum and duodenum and their correlation with symptoms in patients with a duodenal ulcer.

Earlam¹,

Amérigo²,

Kakavoulis³

et al. 1985

Gut

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SUMMARY Clinical data and histology from the oesophagus, gastric antrum, and duodenum were collected from 36 patients undergoing surgery for duodenal ulcer. Gastritis was present in 94% of the patients (25% of atrophic type), oesophagitis in 72% and duodenitis in 39%. Abnormal biopsies were present from all three sites in 33% of the patients. Only one patient showed three normal biopsies. The low incidence of duodenitis does not support the theory that duodenitis is part of the same spectrum as duodenal ulcer. Heartburn was related to the presence of gastritis (100%) and oesophagitis (76%) but not to duodenitis (52%). No relationship was found between the length of history, severity of pain, and histological abnormalities.The correlation of endoscopic appearances and histology of the upper gastrointestinal tract is well established,'13 but papers dealing with the relationship of symptoms and histology have either been inconclusive or shown no association. Fewer reports have correlated symptoms, the histology of oesophagus, stomach, and duodenum and their relationship to each other in biopsies taken simultaneously.8 9 The purpose of this study was to assess whether there was a correlation between the symptoms of duodenal ulceration, severe enough to require operation, and the microscopical appearances of the duodenum, antrum, and oesophagus in biopsies taken at the time of surgery during a truncal vagotomy and pyloroplasty. Methods PATIENTSThirty six patients were studied, 26 men and 10 women with a mean age of 43*5 years (range 19-71 years). All required surgery for duodenal ulcer, which had been diagnosed either radiologically or by endoscopy and confirmed at operation after being unsuccessfully treated medically; only one patient (no 11) was treated preoperatively with cimetidine, because the drug became available towards the end

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confidence: 96%

Histological appearances of oesophagus, antrum and duodenum and their correlation with symptoms in patients with a duodenal ulcer.

Earlam¹,

Amérigo²,

Kakavoulis³

et al. 1985

Gut

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“…However, H. pylori can also play a role in producing GERD. For example, H. pylori ‐associated duodenal ulcer (which is associated with the presence of CagA‐positive strains) has also long been known to be strongly associated with GERD [14–31]. Thus, both the presence and absence of H. pylori may play roles in GERD.…”

Section: New Problems Caused By Absence Of H Pylorimentioning

confidence: 99%

Contemplating the Future without Helicobacter pylori and the Dire Consequences Hypothesis

2007

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Helicobacter pylori is a serious chronic transmissible pathogen that causes gastric structural and functional damage and is a major cause of morbidity and mortality worldwide. H. pylori is one of the digestive tract pathogens that has traveled with mankind since before humans moved out of Africa. Some have suggested that the long association of H. pylori with humans means there must be a benefit and suggest dire consequences will follow its eradication. Fortunately, there are now sufficient experiences with the outcome of treatment and with populations where the infection disappeared long ago to support the conclusion that H. pylori is a serious chronic transmissible pathogen that no one needs, deserves, or desires. The dire consequence hypotheses have proven to be erroneous attempts to blame some of the problems facing the modern world on a pathogen that was and is responsible for much suffering, morbidity, and mortality. It is time to join together to eradicate it and to let H. pylori join smallpox and polio on the hit list of undesirables.

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“…36 male patients with DU and without concomitant hiatal hernia were studied, aged between 19 and 59 (average 36) years, the same group described in a previous paper [6]. The diagnosis of DU was established by a radiological examination of the G1 tract when a crater or at least two of the following findings were demonstrated: (a) thickening and convergence of the duodenal mucosal folds; (b) bulbar scarring; (c) delay in antropyloric emptying.…”

Section: Methodsmentioning

confidence: 99%

Esophagitis and Duodenal Ulcer

Moraes-Filho¹,

Zaterka²,

Hw³

et al. 1974

Digestion

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36 male patients (average age, 36 years) with duodenal ulcer (DU) were studied with the purpose of investigating the incidence of reflux esophagitis. Ten of them had duodenal stenosis due to scarring. All patients were submitted to X-ray and endoscopy of the esophagus, histology of the esophagus, gastric secretion of HCl, and manometry of the lower esophageal sphincter. The results were compared with those of ten controls. The following conclusions were reached: (1) esophagitis according to histological and endoscopic study was found in 61.1% of the patients; (2) the incidence of esophagitis is not significantly related to the duration of the disease, as estimated by its symptoms; (3) duodenal stenosis is not significant in the pathogenesis of the esophagitis; (4) no significant statistical relation was observed between the presence of reflux esophagitis in patients with DU and the gastric secretion of HCl as evaluated in basal conditions and after Histalog stimulation; (5) the length of sphincter and the resting gastroesophageal sphincter pressure were not significantly different in patients with or without esophagitis, and do not depend on the presence or the absence of stenosis or gastric hypersecretion of HCl.

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Lack of specificity of the acid perfusion test in duodenal ulcer patients

Cited by 27 publications

References 11 publications

Histological appearances of oesophagus, antrum and duodenum and their correlation with symptoms in patients with a duodenal ulcer.

Histological appearances of oesophagus, antrum and duodenum and their correlation with symptoms in patients with a duodenal ulcer.

Contemplating the Future without Helicobacter pylori and the Dire Consequences Hypothesis

Esophagitis and Duodenal Ulcer

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