Lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma: A clinicopathological report and review of the literature

Larbcharoensub, Noppadol; Pangpunyakulchai, Duangjai; Aroonroch, Rangsima; Tuntiyatorn, Lojana; Mahaisavariya, Pornchai

doi:10.3892/mco.2017.1488

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…The clinical and radiological findings of lacrimal myoepithelial carcinomas were described with details in only six cases in the literature [ 8 – 10 , 12 – 14 ] (Table 1 ). These features were not specific.…”

Section: Discussionmentioning

confidence: 99%

“…The tumour occurred de novo [ 6 , 8 , 12 ] or on a pre-existing pleomorphic adenoma or adenoid cystic carcinoma [ 9 , 10 , 13 , 14 ]. De novo lacrimal myoepithelial carcinoma would have a poorer prognosis when compared to lacrimal myoepithelial carcinoma arising from pleomorphic adenoma or adenoid cystic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…It demonstrates the myoepithelial nature of neoplastic cells. The diagnosis requires reactivity for cytokeratin and at least one of myoepithelial markers: SMA, glial fibrillary acidic protein (GFAP), calponin, S-100 protein, p63 and CK 5/6 [ 6 – 10 , 12 – 14 , 19 ]. No genetics studies were performed in the reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…These two patients died from de novo myoepithelial carcinoma [ 6 , 12 ]. One patient with myoepithelial carcinoma arising in pleomorphic adenoma presented three uneventful years without any adjuvant therapy [ 14 ]. Additional cases are needed to better characterize primary lacrimal myoepithelial carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Myoepithelial carcinoma of lacrimal gland is rare. To the best of our knowledge, only nine cases have been reported in the literature [ 6 – 14 ]. This lesion presents diagnostic difficulties.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic pitfall: primary myoepithelial carcinoma of the lacrimal gland, case report and literature review

et al. 2018

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BackgroundIn lacrimal gland, lymphomas and inflammatory lesions predominate. Primary epithelial tumours represent less than 30% of lacrimal gland lesions. Myoepithelial carcinoma of lacrimal gland is rare. To the best of our knowledge, only nine cases have been reported in the literature. This lesion presents diagnostic difficulties: non-specific clinical and radiological findings and histological polymorphism. This is well illustrated by the diagnostic pathology errors described in the literature.We report a new case of lacrimal myoepithelial carcinoma with a review of others published cases to try to assess clinico-pathological features and outcome whenever possible of this rare tumour.Case presentationAn 80-year-old Arabian female presented with a 2-month history of swelling over the right eyebrow, pain, proptosis of the right eye and diplopia. Computed tomography demonstrated an ill-defined, homogeneous, contrast-enhancing mass attached to the medial rectus. A biopsy was performed. Microscopic examination showed malignant spindle cells tumour, most consistently to sarcoma or sarcomatoid carcinoma. Immunohistochemical study was not possible because neoplastic material has been exhausted. Subsequently, total exenteration of the right orbit was performed. Immunohistochemical study revealed diffuse positive staining for pancytokeratin AE1/AE3, epithelial membrane antigen (EMA) and smooth muscle actin (SMA) and focal positivity for S100 protein. The lesion was immunonegative for desmin, h-cladesmon, CD34, Melan-A and HMB-45. The tumour was extending to the surgical margins. The patient was lost to follow-up until she developed local tumour progression 3 months after removal. The patient was again lost to follow-up and therefore did not receive any other treatment in our hospital.ConclusionWe present this rare tumour with an unusual location. The use of a complete immunohistochemical panel with epithelial and myoepithelial markers positivity helped us for classification of this poorly differentiated tumour.

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