Lactate/albumin ratio: An early prognostic marker in critically ill patients

Gharipour, Amin; Razavi, Rouzbeh; Gharipour, Mojgan; Mukasa, David

doi:10.1016/j.ajem.2020.06.067

Cited by 64 publications

(86 citation statements)

References 46 publications

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“…In addition, these studies have shown that the mortality prediction performance of the LAR is superior to serum lactate level or albumin level alone in patients with sepsis and septic shock. 10,[18][19][20]33 Consistent with previous clinical studies, in the present study, ROC analysis showed that LAR (AUC=0.824, p<0.001) was superior to the serum albumin (AUC=0.644, p<0.001) and lactate levels (AUC=0.795, p<0.001) for the prediction of 30-day mortality.…”

Section: Discussionsupporting

confidence: 90%

“…Many clinical statuses can lead to altered in the level of serum albumin. 9,10 Especially, hypoalbuminemia is associated with poor prognosis and shorter survival time in many clinical settings such as sepsis, traumatic brain injury, decompensated heart failure, and cancer. 9,[11][12][13] Also, recently published studies showed that a lower level of serum albumin is frequently observed in severe and critically ill COVID-19 patients and it is associated with poor survival.…”

Section: Introductionmentioning

confidence: 99%

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The Lactate/Albumin Ratio As A Prognostic Factor For Short Time Mortality In Critically Ill COVID-19 Patients

Gok¹,

Kasapoğlu²,

Delen³

et al. 2021

Preprint

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Introduction: The prognostic role of the initial lactate/albumin ratio (LAR) in the critically ill COVID-19 patients remains unknown. We aim to evaluate the prognostic value of the initial LAR in predicting 30-days mortality in critically ill COVID-19 patients and compare with the initial level of serum lactate and albumin for the prediction of mortality.Materials and methods: We performed a single-center retrospective and observational clinical study between April 2020 and December 2020. Patients’ clinical and laboratory variables that evaluated in this study were collected within the first 24 hours following the ICU admission.Results: A total of 282 critically ill COVID-19 patients were included in the study. The mean age of the patients was 66.34±12.08 years and 179 (63.5%) of patients were male. Patients who died within 30 days had higher lactate levels (p<0.001), lower levels of serum albumin (p<0.001), and higher levels of LAR (p<0.001). ROC analysis showed that LAR (AUC=0.824) was superior to the serum albumin (AUC=0.644) and lactate levels (AUC=0.795) for the prediction of mortality. Overall ICU mortality rates (75.6% vs 13.1%, p<0.001) were significantly higher in patients with LAR >0.60. LAR >0.60 is a significant and independent prognostic factor for the 30-day mortality in critically ill COVID-19 patients.Conclusion: LAR has a better prognostic performance for predicting 30-day mortality in critically ill COVID-19 patients compared with lactate and albumin

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The Lactate/Albumin Ratio As A Prognostic Factor For Short Time Mortality In Critically Ill COVID-19 Patients

Gok¹,

Kasapoğlu²,

Delen³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Nutritional status and chronic inflammatory disorders also affect albumin levels, albumin levels are therefore low in critically ill patients, and albumin-based predictions could have limitations. 24 , 25 Elevated lactate levels are also associated with poor clinical outcomes and high patient mortality, 26 and the current study accordingly found significantly higher lactate levels among non-survivors. Lactate can be used for the early diagnosis, management, and risk stratification of patients with sepsis.…”

Section: Discussionsupporting

confidence: 55%

Novel biomarker for predicting sepsis mortality: vitamin D receptor

Erdoğan

Fındıklı

2021

J Int Med Res

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Objective There are currently no studies on the role of vitamin D receptor (VDR) levels as a cause of or risk factor for sepsis. We aimed to establish the association between VDR levels and 28-day mortality in critically ill patients with sepsis. Methods This prospective cross-sectional observational study included 148 patients diagnosed with sepsis who were treated in the intensive care unit. We measured VDR levels, laboratory characteristics, and health scores and related them to survival. Results The 148 patients included 96 survivors and 52 non-survivors, with VDR levels of 1.92 and 1.36 ng/mL, respectively. Baseline VDR was a significant predictor of 28-day mortality, with an area under the curve of 0.778. A low VDR level was significantly associated with lower overall survival in patients with sepsis according to Kaplan–Meier curve analysis. VDR levels were also negatively correlated with lactate, C-reactive protein, acute physiological and clinical health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, and disease severity. Conclusions VDR levels were associated with high 28-day mortality and negatively correlated with lactate, C-reactive protein, APACHE II and SOFA scores, and disease severity in patients with sepsis. VDR levels can predict poor outcomes in patients with sepsis.

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“…Many studies have shown that albumin has potential as a prognostic marker of ARF [ 31 – 33 ]. Lactate and albumin are regulated by different mechanisms, so LAR can reduce the influence of a single factor on the regulation mechanism [ 34 ]. Our study also proved that the predictive value of LAR can be better than lactate or albumin alone.…”

Section: Discussionmentioning

confidence: 99%

Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis

Guo

Chen

et al. 2021

PLoS ONE

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Previous studies have shown that lactate/albumin ratio (LAR) can be used as a prognostic biomarker to independently predict the mortality of sepsis and severe heart failure. However, the role of LAR as an independent prognostic factor in all-cause mortality in patients with acute respiratory failure (ARF) remains to be clarified. Therefore, we retrospectively analyzed 2170 patients with ARF in Medical Information Mart for Intensive Care Database III from 2001 to 2012. By drawing the receiver operating characteristic curve, LAR shows a better predictive value in predicting the 30-day mortality of ARF patients (AUC: 0.646), which is higher than that of albumin (AUC: 0.631) or lactate (AUC: 0.616) alone, and even higher than SOFA score(AUC: 0.642). COX regression analysis and Kaplan-Meier curve objectively and intuitively show that high LAR is a risk factor for patients with ARF, which is positively correlated with all-cause mortality. As an easy-to-obtain and objective biomarker, LAR deserves further verification by multi-center prospective studies.

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Lactate/albumin ratio: An early prognostic marker in critically ill patients

Cited by 64 publications

References 46 publications

The Lactate/Albumin Ratio As A Prognostic Factor For Short Time Mortality In Critically Ill COVID-19 Patients

The Lactate/Albumin Ratio As A Prognostic Factor For Short Time Mortality In Critically Ill COVID-19 Patients

Novel biomarker for predicting sepsis mortality: vitamin D receptor

Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis

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